The URO panel of antibodies was developed to immuno-anatomically dissect the nephron from glomerulus to bladder urothelium - these antibodies detect various cell surface antigens specific to segments of the renal tubule. Several have been shown to occur as tissue related markers of renal cancers. URO8 antigen is an acidic glycolipid found in tubular epithelium of normal kidney, portions of Henle's loop. epithelial cells of stomach and colon, luminal surface of bronchial epithelium, skin epidermis, zona granulosa of ovarian follicles, and seminiferous tubules of the testis. URO8 defines a major subset of renal cell carcinoma, reacting with approximately 85% of renal cell carcinomas. A proportion of colon tumors express URO8, while other tumors are negative.