Applications
p-Toluenesulfonylmethyl isocyanide is a synthetic reagent used in the synthesis of triplet drugs with the 1,3,5-trioxazatriquinane skeleton, pyrroles, oxazoles and in imidazoles. It serves as an isonitrile component in a diastereoselective Passerini reaction. Furthermore, it is used in the Van Leusen reaction to convert aldehydes to nitriles.

Solubility
Soluble in chloroform and methanol. Insoluble in water.

Notes
Moisture, air and light sensitive. Store in cool place. Incompatible with strong bases and strong oxidizing agents.