Applications
Tris(hydroxymethyl)aminomethane is used as buffers in biochemistry and molecular biology laboratories. It is used as a primary standard to standardize acid solutions for chemical analysis. It finds application in cell membranes to increase its permeability. As an alternative to sodium bicarbonate, it used in the treatment of metabolic acidosis. It acts as a precursor for the preparation of polymers, oxazolones and oxazolidines.

Solubility
Soluble in water, ethylene glycol, methanol, ethanol, dimethyl formamide, acetone, ethyl acetate, olive oil, chloroform and alkaline solution.

Notes
Hygroscopic. Incompatible with bases and strong oxidizing agents.