Signal Transduction Reagents and Kits | Thermo Fisher Scientific

Protein Kinase Inhibitor Thermo Scientific Chemicals

Inhibitor of protein kinase A This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Ionomycin Calcium Salt, 99% Thermo Scientific Chemicals

Ionomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular...

SB 225002 Thermo Scientific Chemicals

SB 225002 is a selective non-peptide CXCR2 inhibitor which suppresses IL-8 induced neutrophil chemotaxis and margination. In addition, SB 225002 reduces MPO activity, IL-1β, MIP-2, and keratinocyte-derived chemokine (KC) levels.

Tioconazole, 98+% Thermo Scientific Chemicals

Potent inhibitor of cytochrome-P450 This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Ingenol 3-angelate, 98% Thermo Scientific Chemicals

Ingenol 3-Angelate is used as a PKC activator, anticancer, and immunostimulant compound. It is also used to exhibits antileukemic activity, induces nuclear translocation of PKCδ, and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells.

Zolmitriptan Thermo Scientific Chemicals

A serotonin 5HT1D-receptor agonist This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Tropicamide, 99+% Thermo Scientific Chemicals

A muscarinic antagonist This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand...

Erbstatin Analog Thermo Scientific Chemicals

An inhibitor of the EGF receptor associated tyrosine kinase This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Calpain Inhibitor I, 95+% Thermo Scientific Chemicals

It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.

Calpain Inhibitor II, 95+% Thermo Scientific Chemicals

ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I and calpain II. ALLM acts as a very potent inhibitor of cathepsin L and the strongest inhibitor of cathepsin B amongst the peptide aldehydes.

Midostaurin Thermo Scientific Chemicals

Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

Urapidil hydrochloride, 98+% Thermo Scientific Chemicals

alpha-1-Adrenoceptor antagonist and 5-HT1A receptor agonist This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand.

Calmidazolium Chloride Thermo Scientific Chemicals

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+ transport activity in platelet microsomes.

Tacrolimus, 99+% Thermo Scientific Chemicals

Interacts with the immunophilins cyclophilin and FKBP-12.Tacrolimus is used as an immunosuppressive drug that blocks T cell proliferation in vitro. Further, it is used as a research tool in chemically induced dimerization applications.

Trypsin Inhibitor, soybeans Thermo Scientific Chemicals

The soybean trypsin inhibitor has been tested for cell culture applications. It has been used in a study to assess the potential application in animal cell culture of an alkaline protease from a non-toxigenic mangrove isolate of Vibri sp. V26.