The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1(Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12),EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3(Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, Ephrin-A2 (Elf-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk).
ECK; EK4; EK8; EPH-like kinase 4; EPH-like kinase 8; Eph-like tyrosine kinase 1; EPHA2; EPHA3; EPHA4; Ephrin A2; Ephrin A3; Ephrin A4; Ephrin type-A receptor 2; Ephrin type-A receptor 3; Ephrin type-A receptor 4; EphrinA2; EphrinA3; EphrinA4; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; ETK1; HEK; hEK4; HEK8; Human embryo kinase; human embryo kinase 1; receptor protein-tyrosine kinase HEK8; SEK; soluble EPHA2 variant 1; testicular tissue protein Li 64; TYRO1; TYRO1 protein tyrosine kinase; TYRO4; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase receptor MPK-3; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase receptor SEK-1; Tyrosine-protein kinase receptor SEK-2; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase TYRO4