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Product # 14648-1-AP is a rabbit polyclonal antibody raised against the full-length of human NCF4.The MW of this protein is 40 kDa, and this antibody specifically recognizes the 40 kDa protein.
Immunogen sequence: MAVAQQLRA ESDFEQLPDD VAISANIADI EEKRGFTSHF VFVIEVKTKG GSKYLIYRRY RQFHALQSKL EERFGPDSKS SALACTLPTL PAKVYVGVKQ EIAEMRIPAL NAYMKSLLSL PVWVLMDEDV RIFFYQSPYD SEQVPQALRR LRPRTRKVKS VSPQGNSVDR MAAPRAEALF DFTGNSKLEL NFKAGDVIFL LSRINKDWLE GTVRGATGIF PLSFVKILKD FPEEDDPTNW LRCYYYEDTI STIKSVAWEG GACPAFLPSL RPPPLTSPSH GSLSHSKAPS GSQMSHNAVT SHQRPGWPGQ PHSPFPHPTP HFQPDASLLQ PVTPLGTSRW RKISAALPY (1-348 aa encoded by BC002798 )
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CTA-833B7.1; MGC3810; NCF-4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; OTTHUMP00000028736; OTTHUMP00000043756; p40-phox; p40phox; SH3 and PX domain-containing protein 4
Gene Aliases: AI451400; CGD3; NCF; NCF4; P40PHOX; SH3PXD4
UniProt ID: (Human) Q15080, (Mouse) P97369
Entrez Gene ID: (Human) 4689, (Rat) 500904, (Mouse) 17972
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