Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MPEEMDKPL ISLHLVDSDS SLAKVPDEAP KVGILGSGDF ARSLATRLVG SGFKVVVGSR NPKRTARLFP SAAQVTFQEE AVSSPEVIFV AVFREHYSSL CSLSDQLAGK ILVDVSNPTE QEHLQHRESN AEYLASLFPT CTVVKAFNVI SAWTLQAGPR DGNRQVPICG DQPEAKRAVS EMALAMGFMP VDMGSLASAW EVEAM (1-204 aa encoded by BC042150)
The six-transmembrane epithelial antigen of prostate 3 (STEAP3) is a member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. Similar to two other members of the STEAP family (STEAP 2 and STEAP4), STEAP3 promotes both iron and copper reduction. STEAP3 is highly expressed in hematopoietic tissues and colocalizes with the transferrin endosome. Overexpression of STEAP3 stimulates iron reduction; mice lacking STEAP3 are deficient in erythroid ferrireductase activity, suggesting that STEAP3 is an endosomal ferrireductase required for transferrin-dependent iron uptake in erythroid cells.
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