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Invitrogen

ARF1/ARF2/ARF3/ARF4 Polyclonal Antibody

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ARF1/ARF2/ARF3/ARF4 Polyclonal Antibody

Product Details

PA5-18627

Applications
Tested Dilution
Publications

Western Blot (WB)

0.3-1 µg/mL
-

Flow Cytometry (Flow)

10 µg/mL
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (EGLDWLSNQLRNQK) corresponding to the C-terminus amino acids of ARF1 (aa 168-181).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981429

Product Specific Information

This antibody is predicted to react with canine, mouse and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

Target Information

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADP ribosylation factor 1; ADP ribosylation factor 3; ADP ribosylation factor 4; ADP ribosylation factor 5; ADP ribosylation factor 6; ADP-ribosylation factor (ARF1); ADP-ribosylation factor 1; ADP-ribosylation factor 2; ADP-ribosylation factor 3; ADP-ribosylation factor 4; ADP-ribosylation factor 5; ADP-ribosylation factor 6; ARF; ARF6; Liver regeneration-related protein LRRG202; pan ARF; small GTP binding protein; unnamed protein product

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Gene Aliases: 5430400P17Rik; AA407803; Ac1-253; AI788669; AI854770; ARF1; ARF2; ARF3; ARF4; ARF5; ARF6; AW496366; PVNH8

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UniProt ID: (Human) P84077, (Human) P61204, (Human) P18085, (Human) P84085, (Human) P62330, (Mouse) P84078, (Rat) P84079, (Mouse) Q8BSL7, (Rat) P84082, (Rat) P61206, (Mouse) P61205, (Rat) P61751, (Mouse) P61750, (Mouse) P84084, (Rat) P84083, (Mouse) P62331, (Rat) P62332

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Entrez Gene ID: (Dog) 100856517, (Human) 375, (Human) 377, (Dog) 486562, (Human) 378, (Dog) 607073, (Human) 381, (Dog) 475206, (Human) 382, (Dog) 490679, (Mouse) 11840, (Rat) 64310, (Mouse) 11841, (Rat) 79119, (Rat) 140940, (Mouse) 11842, (Rat) 79120, (Mouse) 11843, (Mouse) 11844, (Rat) 79117, (Mouse) 11845, (Rat) 79121

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Function(s)
nucleotide binding magnesium ion binding RNA binding GTPase activity protein binding GTP binding hydrolase activity protein domain specific binding guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding NAD+-protein-arginine ADP-ribosyltransferase activity phospholipase D activator activity obsolete small monomeric GTPase activity GDP binding thioesterase binding signaling adaptor activity protein homodimerization activity poly(A) RNA binding protein N-terminus binding G-protein
Process(es)
regulation of receptor internalization cellular copper ion homeostasis intracellular protein transport protein transport vesicle-mediated transport regulation of Arp2/3 complex-mediated actin nucleation long term synaptic depression dendritic spine organization cellular response to virus mitotic cleavage furrow ingression retrograde vesicle-mediated transport, Golgi to ER ER to Golgi vesicle-mediated transport epidermal growth factor receptor signaling pathway learning cell migration negative regulation of apoptotic process apical protein localization establishment or maintenance of epithelial cell apical/basal polarity positive regulation of transcription from RNA polymerase II promoter response to axon injury regulation of synapse organization cilium morphogenesis dendritic spine development protein localization to cilium regulation of postsynapse organization regulation of cilium assembly regulation of reactive oxygen species metabolic process mitotic cytokinesis liver development vesicle docking involved in exocytosis cell adhesion nervous system development regulation of neuron projection development positive regulation of neuron projection development cell differentiation positive regulation of actin filament polymerization cortical actin cytoskeleton organization endocytic recycling protein localization to cell surface regulation of Rac protein signal transduction protein localization to endosome negative regulation of receptor-mediated endocytosis synaptic vesicle endocytosis positive regulation of protein secretion cell division regulation of filopodium assembly positive regulation of keratinocyte migration regulation of dendritic spine development cellular response to diacyl bacterial lipopeptide protein localization to plasma membrane establishment of epithelial cell polarity ruffle assembly hepatocyte apoptotic process maintenance of postsynaptic density structure positive regulation of focal adhesion disassembly erythrocyte apoptotic process positive regulation of protein localization to plasma membrane positive regulation of mitotic cytokinetic process protein localization to cleavage furrow regulation of presynapse assembly cellular response to nerve growth factor stimulus negative regulation of protein localization to cell surface negative regulation of dendrite development transport actin filament organization small GTPase mediated signal transduction very-low-density lipoprotein particle assembly positive regulation of catalytic activity positive regulation of endocytosis positive regulation of calcium ion-dependent exocytosis Golgi to transport vesicle transport positive regulation of dendritic spine development synaptic vesicle budding lysosomal membrane organization positive regulation of sodium ion transmembrane transport positive regulation of late endosome to lysosome transport positive regulation of ER to Golgi vesicle-mediated transport regulation of phospholipid metabolic process protein ADP-ribosylation brain development activation of phospholipase D activity cell cycle ruffle organization myeloid cell apoptotic process regulation of toll-like receptor 4 signaling pathway positive regulation of establishment of protein localization to plasma membrane actin cytoskeleton organization
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