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Adiponectin Monoclonal Antibody (UMAB104), UltraMAB™

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Adiponectin Monoclonal Antibody (UMAB104), UltraMAB™

Product Details

UM500072CF

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

UMAB104

Immunogen

Human recombinant protein fragment corresponding to amino acids 19-244 of human ADIPOQ produced in HEK293T cell.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 30 kDa adipocyte complement-related protein; adipocyte complement-related 30 kDa protein; adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADPIOQ; gelatin-binding protein 28; unnamed protein product

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Gene Aliases: ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28

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UniProt ID: (Human) Q15848

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Entrez Gene ID: (Human) 9370

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Function(s)
receptor binding cytokine activity hormone activity extracellular matrix structural constituent protein binding sialic acid binding identical protein binding protein homodimerization activity protein serine/threonine kinase activator activity
Process(es)
glucose metabolic process generation of precursor metabolites and energy fatty acid beta-oxidation response to glucose positive regulation of signal transduction negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor endocrine signaling glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of gluconeogenesis negative regulation of blood pressure positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of receptor-mediated endocytosis negative regulation of inflammatory response negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation positive regulation of lipid catabolic process negative regulation of cholesterol import negative regulation of ERK1 and ERK2 cascade cellular response to xenobiotic stimulus positive regulation of monocyte chemotactic protein-1 production positive regulation of cold-induced thermogenesis negative regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration positive regulation of glycogen (starch) synthase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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