In direct ELISAs, approximately 10% cross-reactivity with recombinant human Amnionless is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.
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Protein Aliases: AMN; amnionless homolog (mouse); PRO1028; Protein amnionless; Soluble protein amnionless; type I transmembrane protein; UNQ513/PRO1028; visceral endoderm-specific type 1 transmembrane protein
Gene Aliases: 5033428N14Rik; Amn; AV002116
UniProt ID: (Mouse) Q99JB7
Entrez Gene ID: (Mouse) 93835