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OriGene

BCL6 Monoclonal Antibody (OTI1C3), TrueMAB™

View all (67) BCL6 antibodies
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Product Details

TA804186

Applications Tested Dilution Publications

Immunohistochemistry (Paraffin) (IHC (P))

 1:150 -
Product Specifications

Species Reactivity

 Human

Host/Isotype

 Mouse / IgG2a

Class

 Monoclonal

Type

 Antibody

Clone

 OTI1C3

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-300 of human BCL6 produced in E.coli.
View antigen

Conjugate

 Unconjugated

Form

 liquid

Concentration

 1 mg/mL

Purification

 Affinity chromatography

Storage buffer

 PBS with 1% BSA, 50% glycerol

Contains

 0.02% sodium azide

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

Gene Aliases: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

UniProt ID: (Human) P41182

Entrez Gene ID: (Human) 604

Molecular Function: C2H2 zinc finger transcription factor

Function(s)
protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter cell morphogenesis negative regulation of cell-matrix adhesion germinal center formation regulation of germinal center formation negative regulation of B cell apoptotic process transcription, DNA-templated inflammatory response cellular response to DNA damage stimulus Rho protein signal transduction spermatogenesis negative regulation of cell proliferation actin cytoskeleton organization myeloid cell differentiation B cell differentiation negative regulation of cell growth positive regulation of B cell proliferation positive regulation of histone deacetylation negative regulation of mast cell cytokine production negative regulation of Rho protein signal transduction type 2 immune response regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process regulation of GTPase activity regulation of memory T cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated negative regulation of isotype switching to IgE isotypes erythrocyte development regulation of inflammatory response regulation of neurogenesis regulation of immune response positive regulation of cellular component movement negative regulation of cellular senescence
Process(es)
RNA polymerase II regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding chromatin DNA binding sequence-specific DNA binding metal ion binding

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