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Product Details
PA5-96128
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A recombinant fusion protein containing a sequence corresponding to amino acids 2800-3050 of human BRCA2.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.89 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2807930
Product Specific Information
Immunogen sequence: PFPLPLSSLF SDGGNVGCVD VIIQRAYPIQ WMEKTSSGLY IFRNEREEEK EAAKYVEAQQ KRLEALFTKI QEEFEEHEEN TTKPYLPSRA LTRQQVRALQ DGAELYEAVK NAADPAYLEG YFSEEQLRAL NNHRQMLNDK KQAQIQLEIR KAMESAEQKE QGLSRDVTTV WKLRIVSYSK KEKDSVILSI WRPSSDLYSL LTEGKRYRIY HLATSKSKSK SERANIQLAA TKKTQYQQLP VSDEILFQIY Q
Positive Samples: 293T; Cellular Location: Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Target Information
Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brca 2; brca-2; breast cancer 2, mutation 1, University of Wisconsin-Madison; breast cancer susceptibility protein 2; Breast cancer type 2 susceptibility protein homolog; FANCB; Fanconi anemia group D1 protein homolog; RP11-298P3.4
Gene Aliases: Brca2; Fancd1; RAB163
UniProt ID: (Mouse) P97929
Entrez Gene ID: (Mouse) 12190, (Rat) 360254
Molecular Function:
damaged DNA-binding protein
double-strand break repair via homologous recombination
cytokinesis
oocyte maturation
inner cell mass cell proliferation
DNA repair
nucleotide-excision repair
double-strand break repair
DNA recombination
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
cell cycle
male meiosis I
spermatogenesis
brain development
cell aging
cell proliferation
female gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
response to X-ray
response to UV-C
response to gamma radiation
hemopoiesis
mammary gland development
chromosome breakage
homologous chromosome orientation involved in meiotic metaphase I plate congression
regulation of cytokinesis
negative regulation of mammary gland epithelial cell proliferation
multicellular organism growth
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
chordate embryonic development
histone H3 acetylation
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
replication fork protection
chromosome organization
centrosome duplication
response to nutrient
response to estradiol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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