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CACNA1H, CACNA1G Polyclonal Antibody
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Product Details
OSC00114G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 400-450 of human CACNA1G conjugated to blue carrier protein was used as the antigen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Amount
500 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen shares 95% identity with the corresponding sequences in rat and mouse.
Specificity of this antibody: CACNA1H and CACNA1G.
Target Information
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a1G subunit; Alpha1G-ae; Alpha1G-aef; Alpha1G-af; Alpha1G-bc; Alpha1G-bcd; Alpha1G-bce; Alpha1G-bcef; Alpha1G-be; CACNA1G-a; T-type; CACNA1G-b; T-type; calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1G subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; cav3.1c; domain I; domain II-III linker; domain III-IV linker; domain IV; ion channel; Cav3.1; CACNA1G; low voltage-activated T-type calcium channel alpha-1 subunit Cav3.1; low voltage-activated; alpha 1H; low voltage-activated; CavT.2; low-voltage-activated calcium channel; low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; T-type Cav3.2; unnamed protein product; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent calcium channel alpha 1G subunit; voltage-dependent T-type calcium channel alpha 1G subunit; voltage-gated calcium channel; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; voltage-gated calcium channel subunit alpha Cav3.1; voltage-gated calcium channel subunit alpha Cav3.2
Gene Aliases: [a]1G; a1G; alpha-1G; alpha13.2; Ca(V)T.1; CACNA1HB; Cav3.1; Cav3.1d; Cav3.2; ECA6; EIG6; HALD4; mKIAA1123; MNCb-1209; NBR13; SCA42; SCA42ND
UniProt ID: (Human) O43497, (Human) O95180, (Rat) Q9EQ60
Entrez Gene ID: (Human) 8913, (Human) 8912, (Mouse) 12291, (Rat) 29717, (Rat) 114862, (Mouse) 58226
ion channel activity
voltage-gated calcium channel activity
high voltage-gated calcium channel activity
low voltage-gated calcium channel activity
voltage-gated calcium channel activity involved in AV node cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
scaffold protein binding
voltage-gated ion channel activity
protein binding
voltage-gated sodium channel activity
sinoatrial node development
ion transport
regulation of membrane potential
transmembrane transport
calcium ion import
calcium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
SA node cell action potential
AV node cell action potential
SA node cell to atrial cardiac muscle cell signalling
AV node cell to bundle of His cell signaling
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
calcium ion import across plasma membrane
action potential
regulation of heart rate
system process
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
response to nickel cation
artery smooth muscle contraction
sodium ion transmembrane transport
positive regulation of calcium ion-dependent exocytosis
regulation of calcium ion transport
regulation of atrial cardiac muscle cell membrane depolarization
calcium ion transport into cytosol
membrane depolarization during action potential
muscle contraction
muscle organ development
myoblast fusion
regulation of heart contraction
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
positive regulation of acrosome reaction
cellular response to dexamethasone stimulus
calcium ion transport
positive regulation of cardiac muscle cell contraction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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