Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SYND1; syndecan proteoglycan 1; Syndecan-1; synstatin
Gene Aliases: AA408134; AA409076; CD138; HSPG; SDC; SDC1; Sstn; syn-1; Synd; Synd-1; SYND1; SYNDECA; Syndecan
Molecular Function: cell adhesion molecule cytoskeletal protein defense/immunity protein extracellular matrix glycoprotein extracellular matrix protein membrane-bound signaling molecule signaling molecule