CD16 is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by natural killer (NK) cells, and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC (antibody dependent cell mediated cytotoxicity) by NK cells. IN comparison, CD32 is a 40 kD glycoprotein that acts as a low affinity receptor for IgG (also known as Fc gamma RII), and mediates several functions including endocytosis, activation of secretion, cytotoxicity and immunomodulation. CD32 is expressed by B cells, monocytes, granulocytes and platelets. Further, CD32 is involved in the phagocytosis of immune complexes, the regulation of antibody production by B-cells, and variations of the CD32 gene may increase vulnerability to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been found.
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Protein Aliases: CD16A; CD16B; CD32 receptor 2; Fc gamma Receptor 2; Fc gamma Receptor 3; Fc gamma Receptor II; Fc gamma Receptor III; fc-gamma RIII; Fcg receptor III; FCG2; FcgammaRIII; FCGR2; FCGR2A; FCGR2B; FCGR2C; FCGR3; FCGR3A; FCGR3B; FCGRIII; FCR-10; FCRIII; FCRIIIA; FGFR2B; igG Fc receptor III; low affinity immunoglobulin gamma Fc region receptor III; RP11-5K23.1
Gene Aliases: CD16
Entrez Gene ID: (Mouse) 14131