Product References
Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification.
Bone research
Hwang C,Marini S,Huber AK,Stepien DM,Sorkin M,Loder S,Pagani CA,Li J,Visser ND,Vasquez K,Garada MA,Li S,Xu J,Hsu CY,Yu PB,James AW,Mishina Y,Agarwal S,Li J,Levi B
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Sun Oct 17 00:00:00 EDT 2021
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
Nature communications
Kim JM,Yang YS,Park KH,Ge X,Xu R,Li N,Song M,Chun H,Bok S,Charles JF,Filhol-Cochet O,Boldyreff B,Dinter T,Yu PB,Kon N,Gu W,Takarada T,Greenblatt MB,Shim JH
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Fri May 08 00:00:00 EDT 2020
Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.
Epigenetics & chromatin
Gilmour J,O'Connor L,Middleton CP,Keane P,Gillemans N,Cazier JB,Philipsen S,Bonifer C
12-5987 was used in Flow cytometry/Cell sorting to study the molecular details of how ubiquitous factors are involved in programming tissue specific chromatin.
Tue Jun 04 00:00:00 EDT 2019
Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.
Epigenetics & chromatin
Gilmour J,O'Connor L,Middleton CP,Keane P,Gillemans N,Cazier JB,Philipsen S,Bonifer C
12-5987 was used in Flow cytometry/Cell sorting to study the molecular details of how ubiquitous factors are involved in programming tissue specific chromatin.
Tue Jun 04 00:00:00 EDT 2019
Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.
Journal of cell communication and signaling
Cervantes-Villagrana RD,Color-Aparicio VM,Reyes-Cruz G,Vázquez-Prado J
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Sat Jun 01 00:00:00 EDT 2019
The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification.
Scientific reports
Gilmour J,Assi SA,Noailles L,Lichtinger M,Obier N,Bonifer C
Tue Jul 10 00:00:00 EDT 2018
Isolation and functional assessment of mouse skeletal stem cell lineage.
Nature protocols
Gulati GS,Murphy MP,Marecic O,Lopez M,Brewer RE,Koepke LS,Manjunath A,Ransom RC,Salhotra A,Weissman IL,Longaker MT,Chan CKF
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
12-5987 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
Adventitial Sca1+ Cells Transduced With ETV2 Are Committed to the Endothelial Fate and Improve Vascular Remodeling After Injury.
Arteriosclerosis, thrombosis, and vascular biology
Le Bras A,Yu B,Issa Bhaloo S,Hong X,Zhang Z,Hu Y,Xu Q
12-5987 was used in Flow cytometry/Cell sorting to provide evidence that the genetic manipulation of vascular progenitors is a promising approach to improve vascular function after endothelial injury.
Mon Jan 01 00:00:00 EST 2018
LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.
Nucleic acids research
Stanulovic VS,Cauchy P,Assi SA,Hoogenkamp M
12-5987 was used in Flow cytometry/Cell sorting to show that Lmo2-/- mouse embryonic stem cells differentiated to Flk-1+ haemangioblasts, but less efficiently to haemogenic endothelium.
Fri Sep 29 00:00:00 EDT 2017
Primitive erythrocytes are generated from hemogenic endothelial cells.
Scientific reports
Stefanska M,Batta K,Patel R,Florkowska M,Kouskoff V,Lacaud G
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Tue Jul 25 00:00:00 EDT 2017
Pericyte-expressed Tie2 controls angiogenesis and vessel maturation.
Nature communications
Teichert M,Milde L,Holm A,Stanicek L,Gengenbacher N,Savant S,Ruckdeschel T,Hasanov Z,Srivastava K,Hu J,Hertel S,Bartol A,Schlereth K,Augustin HG
12-5987 was used in Flow cytometry/Cell sorting to expand and revise the current concepts on vascular Angiopoietin/Tie signalling and propose a bidirectional, reciprocal EC-pericyte model of Tie2 signalling.
Tue Jul 18 00:00:00 EDT 2017
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
JCI insight
Ogura S,Kurata K,Hattori Y,Takase H,Ishiguro-Oonuma T,Hwang Y,Ahn S,Park I,Ikeda W,Kusuhara S,Fukushima Y,Nara H,Sakai H,Fujiwara T,Matsushita J,Ema M,Hirashima M,Minami T,Shibuya M,Takakura N,Kim P,Miyata T,Ogura Y,Uemura A
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Thu Feb 09 00:00:00 EST 2017
Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.
Annals of surgery
Loder S,Agarwal S,Sorkin M,Breuler C,Li J,Peterson J,Gardenier J,Hsieh HH,Wang SC,Mehrara BJ,Levi B
Thu Dec 01 00:00:00 EST 2016
Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice.
Scientific reports
Yu H,Moran CS,Trollope AF,Woodward L,Kinobe R,Rush CM,Golledge J
12-5987 was used in Flow cytometry/Cell sorting to examine the effect of angiopoietin-2 administration on experimental aortic aneurysm and atherosclerosis.
Fri Oct 21 00:00:00 EDT 2016
ECM-Dependence of Endothelial Progenitor Cell Features.
Journal of cellular biochemistry
Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment.
Oncotarget
Liguori M,Buracchi C,Pasqualini F,Bergomas F,Pesce S,Sironi M,Grizzi F,Mantovani A,Belgiovine C,Allavena P
12-5987 was used in Flow cytometry/Cell sorting to demonstrate that human and murine monocytes/macrophages are, among leukocytes, uniquely susceptible to TRAIL-mediated killing.
Tue Jul 05 00:00:00 EDT 2016
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.
eLife
Barreiro O,Cibrian D,Clemente C,Alvarez D,Moreno V,Valiente Í,Bernad A,Vestweber D,Arroyo AG,Martín P,von Andrian UH,Sánchez Madrid F
12-5987 was used in Flow cytometry/Cell sorting to describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules.
Wed Jun 15 00:00:00 EDT 2016
FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.
Development (Cambridge, England)
Fleury M,Eliades A,Carlsson P,Lacaud G,Kouskoff V
12-5987 was used in Flow cytometry/Cell sorting to investigate the lineage specification of early mesodermal precursors expressing or not the Forkhead transcription factor FOXF1.
Thu Oct 01 00:00:00 EDT 2015
Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.
Nature communications
Regha K,Assi SA,Tsoulaki O,Gilmour J,Lacaud G,Bonifer C
12-5987 was used in Flow cytometry/Cell sorting to study the differentiation of mouse embryonic stem cells, expressing an inducible RUNX1-ETO gene, into blood cells.
Thu May 28 00:00:00 EDT 2015
Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.
Biology open
Nasrallah R,Knezevic K,Thai T,Thomas SR,Göttgens B,Lacaud G,Kouskoff V,Pimanda JE
12598782 was used in flow cytometry to investigate the role of endoglin in the development of hematopoietic cells.
Fri May 15 00:00:00 EDT 2015
Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.
PloS one
Forget MA,Voorhees JL,Cole SL,Dakhlallah D,Patterson IL,Gross AC,Moldovan L,Mo X,Evans R,Marsh CB,Eubank TD
12-5987 was used in Flow cytometry/Cell sorting to hypothesize that increased levels of CSF1 in breast tumors can regulate differentiation of Tie2- monocytes to a Tie2+ phenotype.
Mon Jan 12 00:00:00 EST 2015
A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.
Development (Cambridge, England)
Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Sun Jun 01 00:00:00 EDT 2014
Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.
Developmental biology
Shi X,Richard J,Zirbes KM,Gong W,Lin G,Kyba M,Thomson JA,Koyano-Nakagawa N,Garry DJ
12-5987 was used in Flow cytometry/Cell sorting to propose that Gata2 functions as a cofactor of Etv2 in the transcriptional regulation of mesodermal progenitors during embryogenesis.
Thu May 15 00:00:00 EDT 2014
ROCK suppression promotes differentiation and expansion of endothelial cells from embryonic stem cell-derived Flk1(+) mesodermal precursor cells.
Blood
Joo HJ,Choi DK,Lim JS,Park JS,Lee SH,Song S,Shin JH,Lim DS,Kim I,Hwang KC,Koh GY
12-5987 was used in Flow cytometry/Cell sorting to demonstrate a versatile method for obtaining an ample amount of ESC-derived ECs for use in therapeutic neovascularisation.
Thu Sep 27 00:00:00 EDT 2012
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Stem cells (Dayton, Ohio)
Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2012
The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.
Journal of immunology (Baltimore, Md. : 1950)
Sudo T,Yokota T,Oritani K,Satoh Y,Sugiyama T,Ishida T,Shibayama H,Ezoe S,Fujita N,Tanaka H,Maeda T,Nagasawa T,Kanakura Y
12-5987 was used in Flow cytometry/Cell sorting to demonstrate that the intensity of ESAM expression is useful to trace activated HSCs.
Sun Jul 01 00:00:00 EDT 2012
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells.
Cell stem cell
Chen MJ,Li Y,De Obaldia ME,Yang Q,Yzaguirre AD,Yamada-Inagawa T,Vink CS,Bhandoola A,Dzierzak E,Speck NA
12-5987 was used in Flow cytometry/Cell sorting to indicate that EMPs and HSCs differentiate from distinct populations of hemogenic endothelial cells.
Fri Dec 02 00:00:00 EST 2011
ER71 directs mesodermal fate decisions during embryogenesis.
Development (Cambridge, England)
Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ
Published figure using CD202b (TIE2) monoclonal antibody (Product # 12-5987-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2011
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
Blood
Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY
12-5987 was used in Flow cytometry/Cell sorting to study the role of Ang1/Tie2 signalling in ESC differentiation.
Thu Aug 25 00:00:00 EDT 2011
Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos.
Development (Cambridge, England)
Yokomizo T,Dzierzak E
12-5987 was used in Flow cytometry/Cell sorting to devise a method to make transparent whole mouse embryos for the observation of hematopoietic clusters.
Mon Nov 01 00:00:00 EDT 2010
Signaling from fibroblast growth factor receptor 2 in immature hematopoietic cells facilitates donor hematopoiesis after intra-bone marrow-bone marrow transplantation.
Stem cells and development
Shigematsu A,Shi M,Okigaki M,Adachi Y,Koike N,Che J,Iwasaki M,Matsubara H,Imamura M,Ikehara S
12-5987 was used in Flow cytometry/Cell sorting to suggest that the antiapoptotic effect of fibroblast growth factor receptor 2 (FGFR2) signalling facilitates the haematopoiesis of FGFR2 Tg mice.
Mon Nov 01 00:00:00 EDT 2010
Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.
Cancer research
Coffelt SB,Tal AO,Scholz A,De Palma M,Patel S,Urbich C,Biswas SK,Murdoch C,Plate KH,Reiss Y,Lewis CE
12-5987 was used in Immunohistochemistry-immunofluorescence to show that exposure of circulating TEMs to tumor-derived ANG-2 stimulates these cells to exhibit a broader, tumor-promoting phenotype.
Thu Jul 01 00:00:00 EDT 2010
The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Blood
Yokota T,Oritani K,Butz S,Kokame K,Kincade PW,Miyata T,Vestweber D,Kanakura Y
12-5987 was used in Flow cytometry/Cell sorting to study hematopoietic stem cell (HSC) characteristics for improved understanding of their development and stage-related functions, showing that the endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Thu Mar 26 00:00:00 EDT 2009
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.
Nature
Lancrin C,Sroczynska P,Stephenson C,Allen T,Kouskoff V,Lacaud G
12-5987 was used in Flow cytometry/Cell sorting to merge the two a priori conflicting theories on the origin of haematopoietic development into a single linear developmental process.
Thu Feb 12 00:00:00 EST 2009
Isolation of cardiac cells from E8.5 yolk sac by ALCAM (CD166) expression.
Mechanisms of development
Murakami Y,Hirata H,Miyamoto Y,Nagahashi A,Sawa Y,Jakt M,Asahara T,Kawamata S
12-5987 was used in Flow cytometry/Cell sorting to indicate that cells retaining a potential to differentiate to the cardiac lineage are present in E8.5 yolk sacs and can be isolated as ALCAM high+, Flk-1- cells.
Wed Mar 19 00:00:00 EDT 2008
Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells.
Cancer gene therapy
Tang Y,Borgstrom P,Maynard J,Koziol J,Hu Z,Garen A,Deisseroth A
Sun Apr 01 00:00:00 EDT 2007
Tracing the first waves of lymphopoiesis in mice.
Development (Cambridge, England)
Yokota T,Huang J,Tavian M,Nagai Y,Hirose J,Zúñiga-Pflücker JC,Péault B,Kincade PW
12-5987 was used in Flow cytometry/Cell sorting to show that lipid accumulation and inflammation are dissociated in the vessel wall in mice with Rip2/ macrophages.
Mon May 01 00:00:00 EDT 2006
transmembrane signal receptor
