Product References
Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade.
Oncoimmunology
Secondini C,Coquoz O,Spagnuolo L,Spinetti T,Peyvandi S,Ciarloni L,Botta F,Bourquin C,Rüegg C
12-5821 was used in Flow cytometry/Cell sorting to investigate the effect of VEGF/VEGFR-2 axis inhibition on lung metastasis, myeloid-derived suppressor cells and regulatory T cells.
Tue Jan 12 00:00:00 EST 2021
Dual Targeting of Endothelial and Cancer Cells Potentiates In Vitro Nanobody-Targeted Photodynamic Therapy.
Cancers
Mashayekhi V,Xenaki KT,van Bergen En Henegouwen PMP,Oliveira S
12-5821 was used in Flow cytometry/Cell sorting to show that the anti-VEGFR2 conjugates are specific and potent PDT agents.
Wed Sep 23 00:00:00 EDT 2020
High expression of endothelial progenitor cell-induced angiogenic markers is associated with bile acid levels in HCC.
Oncology letters
Chen JL,Wang L,Li R,Jiao YF,Yu WF
12-5821 was used in Flow cytometry/Cell sorting to investigate the factors influencing the number of EPCs and circulating progenitor cells (CPCs), as well as the expression levels of vascular endothelial growth factor receptor 2 (VEGFR-2) and CD34, in patients with hepatocellular carcinoma.
Tue Sep 01 00:00:00 EDT 2020
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Nature communications
Chagraoui H,Kristiansen MS,Ruiz JP,Serra-Barros A,Richter J,Hall-Ponselé E,Gray N,Waithe D,Clark K,Hublitz P,Repapi E,Otto G,Sopp P,Taylor S,Thongjuea S,Vyas P,Porcher C
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Tue Dec 18 00:00:00 EST 2018
Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.
eLife
Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Tue Mar 20 00:00:00 EDT 2018
Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.
JCI insight
Murray LA,Habiel DM,Hohmann M,Camelo A,Shang H,Zhou Y,Coelho AL,Peng X,Gulati M,Crestani B,Sleeman MA,Mustelin T,Moore MW,Ryu C,Osafo-Addo AD,Elias JA,Lee CG,Hu B,Herazo-Maya JD,Knight DA,Hogaboam CM,Herzog EL
12-5821 was used in Flow cytometry/Cell sorting to investigate the association of VEGF with the idiopathic pulmonary fibrosis disease state.
Thu Aug 17 00:00:00 EDT 2017
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.
Nature communications
Xu WW,Li B,Guan XY,Chung SK,Wang Y,Yip YL,Law SY,Chan KT,Lee NP,Chan KW,Xu LY,Li EM,Tsao SW,He QY,Cheung AL
12-5821 was used in Flow cytometry/Cell sorting to investigate how the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Fri Feb 10 00:00:00 EST 2017
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.
Nature communications
Xu WW,Li B,Guan XY,Chung SK,Wang Y,Yip YL,Law SY,Chan KT,Lee NP,Chan KW,Xu LY,Li EM,Tsao SW,He QY,Cheung AL
12-5821 was used in Flow cytometry/Cell sorting to investigate how the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Fri Feb 10 00:00:00 EST 2017
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
12-5821 was used in Flow cytometry/Cell sorting to show that EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Thu Jun 02 00:00:00 EDT 2016
The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.
The Journal of clinical investigation
Zhou J,Wu Y,Wang L,Rauova L,Hayes VM,Poncz M,Essex DW
12-5821 was used in Flow cytometry/Cell sorting to investigate the contribution of protein disulfide isomerase CGHC sites during physiological reaction such as thrombosis.
Tue Nov 03 00:00:00 EST 2015
Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells.
Stem cell reports
Wu L,Wary KK,Revskoy S,Gao X,Tsang K,Komarova YA,Rehman J,Malik AB
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Tue Jul 14 00:00:00 EDT 2015
Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant.
International journal of molecular medicine
Song N,Gao L,Qiu H,Huang C,Cheng H,Zhou H,Lv S,Chen L,Wang J
12-5821 was used in Flow cytometry/Cell sorting to determine that MSCs may be safe and effective when used in allogeneic BMT for the treatment of haemotological malignancies.
Wed Jul 01 00:00:00 EDT 2015
Rivaroxaban, a factor Xa inhibitor, improves neovascularization in the ischemic hindlimb of streptozotocin-induced diabetic mice.
Cardiovascular diabetology
Wu TC,Chan JS,Lee CY,Leu HB,Huang PH,Chen JS,Lin SJ,Chen JW
12-5821 was used in Flow cytometry/Cell sorting to demonstrate that rivaroxaban promotes vessel formation in diabetic mice and improves endothelial progenitor cell function under hyperglycemic conditions.
Tue Jun 16 00:00:00 EDT 2015
Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.
Biology open
Nasrallah R,Knezevic K,Thai T,Thomas SR,Göttgens B,Lacaud G,Kouskoff V,Pimanda JE
12582182 was used in flow cytometry to investigate the role of endoglin in the development of hematopoietic cells.
Fri May 15 00:00:00 EDT 2015
SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1).
Development (Cambridge, England)
Yamamizu K,Schlessinger D,Ko MS
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Sat Nov 01 00:00:00 EDT 2014
Mesenchymal-endothelial transition contributes to cardiac neovascularization.
Nature
Ubil E,Duan J,Pillai IC,Rosa-Garrido M,Wu Y,Bargiacchi F,Lu Y,Stanbouly S,Huang J,Rojas M,Vondriska TM,Stefani E,Deb A
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Thu Oct 30 00:00:00 EDT 2014
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
12-5821 was used in Flow cytometry/Cell sorting to investigate the precise role and expression pattern of brain-expressed X-linked genes in endocrine and tissue stem/progenitor cells in mice.
Fri Oct 24 00:00:00 EDT 2014
Sox7 is regulated by ETV2 during cardiovascular development.
Stem cells and development
Behrens AN,Zierold C,Shi X,Ren Y,Koyano-Nakagawa N,Garry DJ,Martin CM
12-5821 was used in Flow cytometry/Cell sorting to investigate the mechanistic interaction between Sox7 and Etv2 during cardiovascular development.
Mon Sep 01 00:00:00 EDT 2014
Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
PloS one
Tornack J,Seiler K,Grützkau A,Grün JR,Onodera M,Melchers F,Tsuneto M
12-5821 was used in Flow cytometry/Cell sorting to suggest that Tal-1 expression is needed to express Runx1 in the mesoderm.
Thu Aug 21 00:00:00 EDT 2014
BMP signaling balances murine myeloid potential through SMAD-independent p38MAPK and NOTCH pathways.
Blood
Cook BD,Evans T
12-5821 was used in Flow cytometry/Cell sorting to investigate SMAD-independent control of haematopoietic potential in mice, identifying a previously unrecognised bone morphogenetic protein signalling axis.
Thu Jul 17 00:00:00 EDT 2014
Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.
Developmental biology
Shi X,Richard J,Zirbes KM,Gong W,Lin G,Kyba M,Thomson JA,Koyano-Nakagawa N,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Thu May 15 00:00:00 EDT 2014
Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.
Stem cells (Dayton, Ohio)
Zhang H,Nieves JL,Fraser ST,Isern J,Douvaras P,Papatsenko D,D'Souza SL,Lemischka IR,Dyer MA,Baron MH
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
12-5821 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.
Stem cells and development
Behrens AN,Iacovino M,Lohr JL,Ren Y,Zierold C,Harvey RP,Kyba M,Garry DJ,Martin CM
Thu Aug 01 00:00:00 EDT 2013
Etv2 rescues Flk1 mutant embryoid bodies.
Genesis (New York, N.Y. : 2000)
Rasmussen TL,Martin CM,Walter CA,Shi X,Perlingeiro R,Koyano-Nakagawa N,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
VEGF/Flk1 signaling cascade transactivates Etv2 gene expression.
PloS one
Rasmussen TL,Shi X,Wallis A,Kweon J,Zirbes KM,Koyano-Nakagawa N,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Mon May 13 00:00:00 EDT 2013
The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development.
PloS one
Laranjeiro R,Alcobia I,Neves H,Gomes AC,Saavedra P,Carvalho CC,Duarte A,Cidadão A,Parreira L
12-5821 was used in Flow cytometry/Cell sorting to indicate a role for the notch ligand delta-like 4 in the quantitative regulation of early hemato-vascular precursors.
Thu Aug 30 00:00:00 EDT 2012
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Stem cells (Dayton, Ohio)
Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2012
Sympathetic nervous system regulates bone marrow-derived cell egress through endothelial nitric oxide synthase activation: role in postischemic tissue remodeling.
Arteriosclerosis, thrombosis, and vascular biology
Récalde A,Richart A,Guérin C,Cochain C,Zouggari Y,Yin KH,Vilar J,Drouet I,Lévy B,Varoquaux O,Silvestre JS
12-5821 was used in Flow cytometry/Cell sorting to describe a major role for the sympathetic nervous system in BM-derived cell egress through stromal eNOS activation.
Thu Mar 01 00:00:00 EST 2012
Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family.
Stem cells and development
Gill JG,Langer EM,Lindsley RC,Cai M,Murphy TL,Murphy KM
12-5821 was used in Flow cytometry/Cell sorting to assess the role of snail to promote the cell-autonomous induction of Flk1(+) endothelial cells in mouse embryonic stem cells.
Fri Jan 20 00:00:00 EST 2012
Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease.
JACC. Cardiovascular imaging
van der Bogt KE,Hellingman AA,Lijkwan MA,Bos EJ,de Vries MR,van Rappard JR,Fischbein MP,Quax PH,Robbins RC,Hamming JF,Wu JC
12-5821 was used in Flow cytometry/Cell sorting to assess the kinetics of transplanted MNCs in PAD using in vivo molecular imaging.
Sun Jan 01 00:00:00 EST 2012
A triple-targeted ultrasound contrast agent provides improved localization to tumor vasculature.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
Warram JM,Sorace AG,Saini R,Umphrey HR,Zinn KR,Hoyt K
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2011
Assessment of the myogenic stem cell compartment following transplantation of Pax3/Pax7-induced embryonic stem cell-derived progenitors.
Stem cells (Dayton, Ohio)
Darabi R,Santos FN,Filareto A,Pan W,Koene R,Rudnicki MA,Kyba M,Perlingeiro RC
12-5821 was used in Flow cytometry/Cell sorting to investigate Pax3/Pax7-induced embryonic stem cell-derived progenitors as a therapeutic application of ES-derived myogenic progenitors in muscle disorders.
Sun May 01 00:00:00 EDT 2011
Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs.
Stem cells (Dayton, Ohio)
Gill JG,Langer EM,Lindsley RC,Cai M,Murphy TL,Kyba M,Murphy KM
12-5821 was used in Flow cytometry/Cell sorting to investigate the role of Snail and microRNA-200 in regulating epithelial-to-mesenchymal transition and embryonic stem cell differentiation.
Sun May 01 00:00:00 EDT 2011
Recapitulation of the embryonic cardiovascular progenitor cell niche.
Biomaterials
Schenke-Layland K,Nsair A,Van Handel B,Angelis E,Gluck JM,Votteler M,Goldhaber JI,Mikkola HK,Kahn M,Maclellan WR
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Fri Apr 01 00:00:00 EDT 2011
Hepatoblast-like progenitor cells derived from embryonic stem cells can repopulate livers of mice.
Gastroenterology
Li F,Liu P,Liu C,Xiang D,Deng L,Li W,Wangensteen K,Song J,Ma Y,Hui L,Wei L,Li L,Ding X,Hu Y,He Z,Wang X
12-5821 was used in Flow cytometry/Cell sorting to identify and purify ES cell-derived hepatoblast-like progenitor cells and to explore their capacity for liver repopulation in mice after in vitro expansion.
Wed Dec 01 00:00:00 EST 2010
Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival.
Stem cells (Dayton, Ohio)
Ma M,Ding S,Lundqvist A,San H,Fang F,Konoplyannikov M,Berry C,Beltran LE,Chen G,Kovacic JC,Boehm M
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 2010
Nox2-containing NADPH oxidase deficiency confers protection from hindlimb ischemia in conditions of increased oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology
Haddad P,Dussault S,Groleau J,Turgeon J,Michaud SE,Ménard C,Perez G,Maingrette F,Rivard A
12-5821 was used in Flow cytometry/Cell sorting to investigate the role for Nox2-containing NADPH oxidase in the modulation of neovascularisation in conditions of increased oxidative stress.
Thu Oct 01 00:00:00 EDT 2009
Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.
Hepatology (Baltimore, Md.)
Asahina K,Tsai SY,Li P,Ishii M,Maxson RE,Sucov HM,Tsukamoto H
Published figure using CD309 (FLK1) monoclonal antibody (Product # 12-5821-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2009
Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice.
Antioxidants & redox signaling
Ajijola OA,Dong C,Herderick EE,Ma Q,Goldschmidt-Clermont PJ,Yan Z
12-5821 was used in Flow cytometry/Cell sorting to determine whether exercise-induced enhancement of endothelial progenitor cells is associated with reduced atherosclerosis and inflammation.
Thu Jan 01 00:00:00 EST 2009
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1.
Cell research
Sheng H,Wang Y,Jin Y,Zhang Q,Zhang Y,Wang L,Shen B,Yin S,Liu W,Cui L,Li N
12-5821 was used in Flow cytometry/Cell sorting to investigate the role that IFNγ plays in mesenchymal stem cell mediated suppression of T cell proliferation.
Fri Aug 01 00:00:00 EDT 2008
Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice.
Circulation research
Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H
12-5821 was used in Flow cytometry/Cell sorting to indicate that vascular EpoR system also plays an important role in angiogenesis in response to hindlimb ischemia.
Fri Mar 16 00:00:00 EDT 2007
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling.
Journal of cell science
Kano MR,Morishita Y,Iwata C,Iwasaka S,Watabe T,Ouchi Y,Miyazono K,Miyazawa K
12-5821 was used in Flow cytometry/Cell sorting to demonstrate that enhancement of endogenous PDGF-B-PDGFR signaling is critical for the synergistic effect of VEGF-A and FGF-2 on neoangiogenesis in adults.
Mon Aug 15 00:00:00 EDT 2005
transmembrane signal receptor
