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CD51/CD61 Antibody (MA5-44118) in Flow
Separation of REH cells stained using anti-human CD51/CD61 (23C6) PE Monoclonal antibody (Product # MA5-44118), 10 µL reagent per million cells in 100 µL of cell suspension (red-filled) from REH cells stained using mouse IgG1 isotype control (MOPC-21) PE antibody (concentration in sample 7 µg/mL, same as CD51/CD61 PE concentration, black-dashed) in flow cytometry analysis (surface staining) of REH cell suspension.
Product Details
MA5-44118
Product Specifications
Species Reactivity
Chicken,
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
23C6
Immunogen
A cell suspension containing osteoclasts from osteoclastomas
Conjugate
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Size-exclusion chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
RRID
AB_2913050
Target Information
CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antigen CD61; antigen identified by monoclonal antibody L230; CD51; CD61; GPIIIa; integrin alpha V; integrin alpha-5 beta-3; Integrin alpha-V; Integrin alpha-V heavy chain; Integrin alpha-V light chain; integrin alphaVbeta3; Integrin beta; integrin beta 3; Integrin beta-3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Platelet membrane glycoprotein IIIa; Vitronectin receptor; vitronectin receptor alpha subunit; Vitronectin receptor subunit alpha
Gene Aliases: BDPLT16; BDPLT2; CD51; CD61; GP3A; GPIIIa; GT; integrin; ITGAV; ITGB3; MSK8; VNRA; VTNR
UniProt ID: (Human) P06756, (Chicken) P26008, (Human) P05106
Entrez Gene ID: (Human) 3685, (Chicken) 396420, (Human) 3690, (Chicken) 374209
Molecular Function:
integrin
angiogenesis
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
positive regulation of cell proliferation
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
cell growth
cell migration
extracellular matrix organization
positive regulation of cell migration
cell-substrate adhesion
negative regulation of lipid transport
positive regulation of osteoblast proliferation
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
endodermal cell differentiation
apolipoprotein A-I-mediated signaling pathway
apoptotic cell clearance
negative regulation of low-density lipoprotein particle receptor biosynthetic process
positive regulation of cell adhesion
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
negative regulation of lipoprotein metabolic process
regulation of phagocytosis
leukocyte migration
negative chemotaxis
entry of symbiont into host cell by promotion of host phagocytosis
ERK1 and ERK2 cascade
calcium ion transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
regulation of apoptotic cell clearance
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
cell adhesion mediated by integrin
regulation of transforming growth factor beta activation
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
platelet degranulation
cell-substrate junction assembly
blood coagulation
positive regulation of endothelial cell migration
smooth muscle cell migration
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
activation of protein kinase activity
tube development
wound healing
regulation of bone resorption
mesodermal cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
angiogenesis involved in wound healing
platelet aggregation
virus receptor activity
opsonin binding
fibronectin binding
protease binding
protein kinase C binding
voltage-gated calcium channel activity
protein binding
coreceptor activity
fibroblast growth factor binding
C-X3-C chemokine binding
insulin-like growth factor I binding
neuregulin binding
metal ion binding
transforming growth factor beta binding
extracellular matrix binding
extracellular matrix protein binding
protein disulfide isomerase activity
platelet-derived growth factor receptor binding
enzyme binding
identical protein binding
vascular endothelial growth factor receptor 2 binding
cell adhesion molecule binding
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