|Flow Cytometry (Flow)||1.2 ug/10^6 cells|
|Immunohistochemistry (Frozen) (IHC (F))||1-2 ug/10^6 cells|
|Western Blot (WB)||4 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||CEA partially purified from a perchloric acid extract from liver metastases of colonic tumors.|
|Storage buffer||PBS, pH 7.2|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody recognizes native human CEACAM5, 6 protein expressed in transfected mammalian cells.
CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66c; CD66e; CEA; Cluster of Differentiation 66c; Meconium antigen 100; NCA; Non-specific crossreacting antigen; Normal cross-reacting antigen
Gene Aliases: CD66c; CD66e; CEA; CEACAM5; CEACAM6; CEAL; NCA
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor kinase membrane-bound signaling molecule protein kinase signaling molecule transferase
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