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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
Flow Cytometry (Flow) |
1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI2A11 |
Immunogen |
Full length human recombinant protein of CENPH produced in HEK293T cell |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.88 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 1% BSA, 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2724119 |
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CENP-H; CENPH; Centromere protein H; Interphase centromere complex protein 35; kinetochore protein CENP-H
Gene Aliases: CENPH; ICEN35
UniProt ID: (Human) Q9H3R5
Entrez Gene ID: (Human) 64946
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