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CHRNA5 Monoclonal Antibody (3G8C11)

CHRNA5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CHRNA5 Antibody (66363-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human bladder tissue slide using 66363-1-IG ( CHRNA5 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

66363-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3G8C11

Immunogen

CHRNA5 Fusion Protein Ag4447 (32-251 aa encoded by BC033639)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: GAQRGLSEP SSIAKHEDSL LKDLFQDYER WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRYNGTVTW TPPANYKSSC TIDVTFFPFD LQNCSMKFGS WTYDGSQVDI ILEDQDVDKR DFFDNGEWEI VSATGSKGNR TDSCCWYPYV TYSFVIKRLP L (32-251 aa encoded by BC033639)

Target Information

Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

Acetylcholine promotes chronic stress-induced lung adenocarcinoma progression via α5-nAChR/FHIT pathway.

Cellular and molecular life sciences : CMLS

Jiao Y,Kang G,Pan P,Fan H,Li Q,Li X,Li J,Wang Y,Jia Y,Zhang L,Sun H,Ma X

Fri Apr 07 00:00:00 EDT 2023

α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer.

Carcinogenesis

Zhang Q,Jia Y,Pan P,Zhang X,Jia Y,Zhu P,Chen X,Jiao Y,Kang G,Zhang L,Ma X

Thu May 19 00:00:00 EDT 2022

Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling.

Cell communication and signaling : CCS

Zhu P,Jin Z,Kang G,Jia Y,Liu D,Zhang Q,Guo F,Jia Y,Jiao Y,Li J,Sun H,Ma X

Mon Aug 15 00:00:00 EDT 2022

CHRNA5 Is Overexpressed in Patients with Psoriasis and Promotes Psoriasis-Like Inflammation in Mouse Models.

The Journal of investigative dermatology

Wang J,Li X,Zhang P,Yang T,Liu N,Qin L,Ma G,Li X,Fan H,Huang S,Dang N

Tue Nov 01 00:00:00 EDT 2022

The role of α5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration.

Toxicology

Jia Y,Zhang Q,Liu Z,Pan P,Jia Y,Zhu P,Jiao Y,Kang G,Ma X

Tue Mar 15 00:00:00 EDT 2022

The α5-nAChR/PD-L1 axis facilitates lung adenocarcinoma cell migration and invasion.

Human cell

Zhu P,Kang G,Jiao Y,Gui C,Fan H,Li X,Jia Y,Zhang L,Ma X

Fri Jul 01 00:00:00 EDT 2022

Bioinformatics

Protein Aliases: acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 5 (neuronal); cholinergic receptor; Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5; cholinergic receptor, nicotinic alpha 5; cholinergic receptor, nicotinic, alpha 5 (neuronal); nAChR alpha 5; Neuronal acetylcholine receptor subunit alpha-5; neuronal nicotinic acetylcholine receptor, alpha5 subunit; nicotinic acetylcholine receptor alpha5 subunit

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Gene Aliases: Acra-5; Acra5; CHRNA5; LNCR2; NACHRA5

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UniProt ID: (Human) P30532, (Mouse) Q2MKA5

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Entrez Gene ID: (Pig) 100156023, (Human) 1138, (Mouse) 110835

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Function(s)

acetylcholine-activated cation-selective channel activity protein binding ligand-gated ion channel activity acetylcholine receptor activity acetylcholine binding protein heterodimerization activity ion channel activity extracellular ligand-gated ion channel activity ligand-gated ion channel

Process(es)

transport signal transduction chemical synaptic transmission synaptic transmission, cholinergic neuromuscular synaptic transmission behavioral response to nicotine cation transmembrane transport ion transport cation transport response to nicotine

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CHRNA5 Monoclonal Antibody (3G8C11)

CHRNA5 Antibody (66363-1-IG) in IHC (P)

Product Details

66363-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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