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Product Details
66763-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2D3B6
Immunogen
CRM1 Fusion Protein Ag27337 (301-540 aa encoded by BC032847)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NTNIRLAYS NGKDDEQNFI QNLSLFLCTF LKEHDQLIEK RLNLRETLME ALHYMLLVSE VEETEIFKIC LEYWNHLAAE LYRESPFSTS ASPLLSGSQH FDVPPRRQLY LPMLFKVRLL MVSRMAKPEE VLVVENDQGE VVREFMKDTD SINLYKNMRE TLVYLTHLDY VDTERIMTEK LHNQVNGTEW SWKNLNTLCW AIGSISGAMH EEDEKRFLVT VIKDLLGLCE QKRGKDNKAI I (301-540 aa encoded by BC032847)
Target Information
Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: chromosome region maintenance 1 homolog; Chromosome region maintenance 1 protein homolog; Exp1; exportin 1 (CRM1 homolog, yeast); exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; Exportin-1; exportin-1 (required for chromosome region maintenance)
Gene Aliases: AA420417; CRM1; emb; Exp1; XPO1
UniProt ID: (Human) O14980, (Rat) Q80U96, (Mouse) Q6P5F9
Entrez Gene ID: (Human) 7514, (Rat) 85252, (Mouse) 103573
ribosomal large subunit export from nucleus
ribosomal small subunit export from nucleus
negative regulation of transcription from RNA polymerase II promoter
protein export from nucleus
sister chromatid cohesion
regulation of centrosome duplication
viral process
protein localization to nucleus
regulation of protein catabolic process
response to drug
regulation of mRNA stability
regulation of protein export from nucleus
mRNA transport
intracellular transport of virus
transport
intracellular protein transport
protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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