Immunogen sequence: NTNIRLAYS NGKDDEQNFI QNLSLFLCTF LKEHDQLIEK RLNLRETLME ALHYMLLVSE VEETEIFKIC LEYWNHLAAE LYRESPFSTS ASPLLSGSQH FDVPPRRQLY LPMLFKVRLL MVSRMAKPEE VLVVENDQGE VVREFMKDTD SINLYKNMRE TLVYLTHLDY VDTERIMTEK LHNQVNGTEW SWKNLNTLCW AIGSISGAMH EEDEKRFLVT VIKDLLGLCE QKRGKDNKAI I (301-540 aa encoded by BC032847)
Exportin - 1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of the nuclear export is thought to be conferred by an asymmetric distribution of the GTP and GDP bound forms of Ran between the cytoplasm and nucleus.
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Protein Aliases: chromosome region maintenance 1 homolog; Chromosome region maintenance 1 protein homolog; Exp1; exportin 1 (CRM1 homolog, yeast); exportin 1 (CRM1, yeast, homolog); exportin 1, CRM1 homolog; Exportin-1; exportin-1 (required for chromosome region maintenance)
Gene Aliases: AA420417; CRM1; emb; Exp1; XPO1
Molecular Function: transporter