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Product Details
ACR-057-200UL
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:400 | - |
Immunohistochemistry (Frozen) (IHC (F)) |
1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
CGKRAIILETRQHR, corresponding to amino acid residues 58-71 of human CX3CL1, Extracellular, N-terminus |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
0.8 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 1% BSA |
Contains |
0.05% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Reconstitution: 1 X 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; FK; Fractalkine; Neurotactin; Processed fractalkine; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; Small-inducible cytokine D1
Gene Aliases: A-152E5.2; AB030188; ABCD-3; Acc1; AI848747; C3Xkine; CX3C; CX3CL1; CXC3; CXC3C; D8Bwg0439e; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1
UniProt ID: (Human) P78423, (Rat) O55145, (Mouse) O35188
Entrez Gene ID: (Human) 6376, (Rat) 89808, (Mouse) 20312
Molecular Function:
cytokine
intercellular signal molecule
response to hypoxia
microglial cell activation
positive regulation of neuroblast proliferation
leukocyte migration involved in inflammatory response
monocyte chemotaxis
chemotaxis
defense response
immune response
cell adhesion
G-protein coupled receptor signaling pathway
aging
positive regulation of macrophage chemotaxis
cytokine-mediated signaling pathway
platelet activation
neutrophil chemotaxis
leukocyte chemotaxis
positive regulation of transforming growth factor beta1 production
integrin activation
positive regulation of GTPase activity
positive regulation of angiogenesis
negative regulation of vasoconstriction
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
negative regulation of cytokine secretion
positive regulation of inflammatory response
leukocyte adhesive activation
positive regulation of calcium-independent cell-cell adhesion
angiogenesis involved in wound healing
inhibitory postsynaptic potential
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of cell migration
wound healing
positive regulation of cell adhesion
cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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