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Invitrogen
CYP26A1 Recombinant Rabbit Monoclonal Antibody (ARC2126)
Product Details
MA5-38155
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC2126
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 201-450 of human CYP26A1 (O43174)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898073
Product Specific Information
Positive Samples: Rat liver^M
^M
Immunogen sequence: AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM LPHPEDASRF SFIPFGGGLR SCVGKEFAKI
Target Information
CYP26A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CYP26A1; Cytochrome P450 26A1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, 26, retinoic acid; cytochrome P450, 26, retinoic acid A1; cytochrome P450, family 26, subfamily A, polypeptide 1; cytochrome P450, subfamily XXVIA, polypeptide 1; Cytochrome P450RAI; hP450RAI; P450, retinoic acid-inactivating, 1; Retinoic acid 4-hydroxylase; retinoic acid hydrolase; retinoic acid hydroxylase; Retinoic acid-metabolizing cytochrome
Gene Aliases: CP26; CYP26; CYP26A1; P450RA; P450RAI; P450RAI1; RAH
UniProt ID: (Human) O43174, (Mouse) O55127
Entrez Gene ID: (Human) 1592, (Mouse) 13082, (Rat) 154985
retinoic acid binding
iron ion binding
retinoic acid 4-hydroxylase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
oxygen binding
heme binding
monooxygenase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
fluorene oxygenase activity
mono-butyltin dioxygenase activity
tri-n-butyltin dioxygenase activity
di-n-butyltin dioxygenase activity
methylsilanetriol hydroxylase activity
methyl tertiary butyl ether 3-monooxygenase activity
4-nitrocatechol 4-monooxygenase activity
4-chlorophenoxyacetate monooxygenase activity
tert-butanol 2-monooxygenase activity
alpha-pinene monooxygenase activity
dimethylsilanediol hydroxylase activity
ammonia monooxygenase activity
hydroxymethylsilanetriol oxidase activity
2-hydroxyisobutyrate 3-monooxygenase activity
alpha-pinene dehydrogenase activity
bisphenol A hydroxylase B activity
2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity
9-fluorenone-3,4-dioxygenase activity
anthracene 9,10-dioxygenase activity
2-(methylthio)benzothiazole monooxygenase activity
2-hydroxybenzothiazole monooxygenase activity
benzothiazole monooxygenase activity
2,6-dihydroxybenzothiazole monooxygenase activity
pinacolone 5-monooxygenase activity
thioacetamide S-oxygenase activity
thioacetamide S-oxide S-oxygenase activity
endosulfan monooxygenase I activity
N-nitrodimethylamine hydroxylase activity
4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity
endosulfan ether monooxygenase activity
pyrene 4,5-monooxygenase activity
pyrene 1,2-monooxygenase activity
1-hydroxypyrene 6,7-monooxygenase activity
1-hydroxypyrene 7,8-monooxygenase activity
phenylboronic acid monooxygenase activity
spheroidene monooxygenase activity
metal ion binding
oxygenase
vitamin metabolic process
xenobiotic metabolic process
retinoic acid catabolic process
retinoic acid metabolic process
negative regulation of retinoic acid receptor signaling pathway
oxidation-reduction process
central nervous system development
anterior/posterior pattern specification
neural crest cell development
retinoic acid receptor signaling pathway
cellular response to retinoic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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