Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:200-1:2,000 | View 6 publications 6 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20 | - |
Immunocytochemistry (ICC/IF) |
1:125 | View 3 publications 3 publications |
Flow Cytometry (Flow) |
Assay-dependent | - |
Immunoprecipitation (IP) |
1-3 µL | - |
Product Specifications | |
---|---|
Species Reactivity |
Hamster, Human, Rat |
Published species |
Human, Mouse, Pig, Rat |
Host/Isotype |
Mouse |
Class |
Monoclonal |
Type |
Antibody |
Clone |
7C8 |
Immunogen |
Intercellular membrane protein-containing vesicles (containing GLUT4) from rat. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
Conc. Not Determined |
Storage buffer |
ascites |
Contains |
0.05% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_779568 |
MA3-600 detects caveolin from human, rat and hamster samples.
MA3-600 has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures. By Western blot, this antibody detects a 19-21 kDa band from transfected HEK293 (B8) cells, with a non-specific band appearing at 65-70 kDa.
The MA3-600 immunogen is intercellular membrane protein-containing vesicles obtained from rat.
Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. It can bind with DPP4 and induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations affecting the CAV1 gene can result in congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, or partial lipodystrophy/congenital cataracts, and neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: caveolae; caveolin 1, caveolae protein, 22kDa; caveolin caveolae protein 22 kDa; Caveolin-1; cell growth-inhibiting protein 32; HGNC:1527; OTTHUMP00000196475
Gene Aliases: BSCL3; CAV; CAV1; Caveolin-1; CGL3; LCCNS; MSTP085; PPH3; VIP21
UniProt ID: (Human) Q03135
Entrez Gene ID: (Human) 857, (Rat) 25404, (Chinese hamster) 100753021
Molecular Function:
scaffold/adaptor protein
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