Product References
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).
Molecular & cellular proteomics : MCP
Van Puyenbroeck V,Claeys E,Schols D,Bell TW,Vermeire K
MA5-12717 was used in Western Blotting to demonstrate that a small signal peptide-binding drug is able to down-modulate the expression of human CD4 and sortilin, apparently with low impact on the cellular proteome.
Wed Feb 01 00:00:00 EST 2017
The CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.
Cell cycle (Georgetown, Tex.)
Paternot S,Colleoni B,Bisteau X,Roger PP
MA5-12717 was used in Western Blotting to study the differences in PD0332991 activity on the activation of cyclin D-CDK4/6 complexes, dependent on p21 binding.
Thu Aug 20 00:00:00 EDT 2015
Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors.
Pigment cell & melanoma research
Basile KJ,Le K,Hartsough EJ,Aplin AE
MA5-12717 was used in western blot to study the ability of next-generation RAF inhibitors to inhibit signaling mediated by splice variants of mutant BRAF
Thu May 01 00:00:00 EDT 2014
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.
PLoS genetics
Bisteau X,Paternot S,Colleoni B,Ecker K,Coulonval K,De Groote P,Declercq W,Hengst L,Roger PP
MA5-12717 was used in western blot to study the roles CDK7 and p21 in regulating the T172 phosphorylation of CDK4 at the restriction point
Wed May 01 00:00:00 EDT 2013
Alteration of G1/S transition regulators influences recurrences in head and neck squamous carcinomas.
Journal of cellular physiology
Canzonieri V,Barzan L,Franchin G,Vaccher E,Talamini R,Sulfaro S,Baldassarre G
MA5-12717 was used in immunohistochemistry to study the role of the G1/S transition regulators in the recurrence of head and neck squamous carcinomas
Sun Jan 01 00:00:00 EST 2012
Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Sarkar R,Hunter IA,Rajaganeshan R,Perry SL,Guillou P,Jayne DG
MA5-12717 was used in immunohistochemistry to investigate the prognostic significance cyclin D2 expression in liver metastasis
Thu Apr 01 00:00:00 EDT 2010
β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis.
BMC developmental biology
Mirando AJ,Maruyama T,Fu J,Yu HM,Hsu W
MA5-12717 was used in immunohistochemistry to investigate the role of beta-catenin/cyclin D1 during calvarial morphogenesis
Fri Nov 26 00:00:00 EST 2010
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
Blood
Tiedemann RE,Schmidt J,Keats JJ,Shi CX,Zhu YX,Palmer SE,Mao X,Schimmer AD,Stewart AK
MA5-12717 was used in western blot to screen for compounds that suppress cyclin D2 promoter transcription
Thu Apr 23 00:00:00 EDT 2009
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.
Molecular and cellular biology
Bockstaele L,Bisteau X,Paternot S,Roger PP
MA5-12717 was used in western blot to study differences in the activation of the cyclin-dependent kinases Cdk4 and Cdk6 in intact cells
Sat Aug 01 00:00:00 EDT 2009
Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation.
Hepatology (Baltimore, Md.)
Zhang Y,Xu P,Park K,Choi Y,Moore DD,Wang L
MA5-12717 was used in western blot to study the mechanism by which the nuclear receptor family member SHP suppresses hepatic carcinogenesis
Tue Jul 01 00:00:00 EDT 2008
Cell cycle regulators and outcome of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer: the International Adjuvant Lung Cancer Trial Biologic Program.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Filipits M,Pirker R,Dunant A,Lantuejoul S,Schmid K,Huynh A,Haddad V,André F,Stahel R,Pignon JP,Soria JC,Popper HH,Le Chevalier T,Brambilla E
MA5-12717 was used in immunohistochemistry to study the predictive/prognostic value of cell cycle regulators in adjunct cisplatin chemotherapy of non-small cell lung cancer
Sun Jul 01 00:00:00 EDT 2007
Nuclear localization of barrier-to-autointegration factor is correlated with progression of S phase in human cells.
Journal of cell science
Haraguchi T,Koujin T,Osakada H,Kojidani T,Mori C,Masuda H,Hiraoka Y
MA5-12717 was used in western blot to investigate the correlation between nuclear localization of barrier-to-autointegration factor and S phase progression in human cells
Fri Jun 15 00:00:00 EDT 2007
Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Blood
Piva R,Chiarle R,Manazza AD,Taulli R,Simmons W,Ambrogio C,D'Escamard V,Pellegrino E,Ponzetto C,Palestro G,Inghirami G
MA5-12717 was used in western blot to examine the consequences of constitutive expression of anaplastic lymphoma kinase
Sun Jan 15 00:00:00 EST 2006
Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3.
Cancer research
Leslie K,Lang C,Devgan G,Azare J,Berishaj M,Gerald W,Kim YB,Paz K,Darnell JE,Albanese C,Sakamaki T,Pestell R,Bromberg J
MA5-12717 was used in western blot to study the role of STAT3 in regulating cyclin D1 expression and the correlation between elevated cyclin D1 and activated STAT3 in breast cancer
Wed Mar 01 00:00:00 EST 2006
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".
Molecular and cellular biology
Bockstaele L,Kooken H,Libert F,Paternot S,Dumont JE,de Launoit Y,Roger PP,Coulonval K
MA5-12717 was used in Western Blot to indicate that CDK4-activating kinase(s) should be reconsidered.
Sat Jul 01 00:00:00 EDT 2006
Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture.
Molecular endocrinology (Baltimore, Md.)
Paternot S,Dumont JE,Roger PP
MA5-12717 was used in western blot to study the roles of cyclin D1 and cyclin D3 in different mitogenic modes of human thyrocytes
Fri Dec 01 00:00:00 EST 2006
Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profiling.
Blood
Fu K,Weisenburger DD,Greiner TC,Dave S,Wright G,Rosenwald A,Chiorazzi M,Iqbal J,Gesk S,Siebert R,De Jong D,Jaffe ES,Wilson WH,Delabie J,Ott G,Dave BJ,Sanger WG,Smith LM,Rimsza L,Braziel RM,Müller-Hermelink HK,Campo E,Gascoyne RD,Staudt LM,Chan WC
MA5-12717 was used in immunohistochemistry to study the clinicopathology and gene expression profiles of 6 cases of cyclin D1-negative mantle cell lymphoma
Thu Dec 15 00:00:00 EST 2005
Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas.
British journal of cancer
Mermelshtein A,Gerson A,Walfisch S,Delgado B,Shechter-Maor G,Delgado J,Fich A,Gheber L
MA5-12717 was used in western blot to study the expression of cyclins D1, D2 and D3 in colon cancer and their role in carcinogenesis
Mon Aug 08 00:00:00 EDT 2005
Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis.
Endocrinology
Fortemaison N,Blancquaert S,Dumont JE,Maenhaut C,Aktories K,Roger PP,Dremier S
MA5-12717 was used in western blot to study the role of Rho proteins in actin cytoskeleton functions during thyroid cell differentiation and mitogenesis
Thu Dec 01 00:00:00 EST 2005
Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells.
Leukemia research
Siitonen T,Koistinen P,Savolainen ER
MA5-12717 was used in western blot to investigate the effect of valproate on Ara-C cytotoxicity in acute myeloblastic leukemia cells and its mechanism
Tue Nov 01 00:00:00 EST 2005
Nuclear beta-catenin expression is rare and its potential association with short survival in colorectal signet-ring cell carcinoma.
Applied immunohistochemistry & molecular morphology : AIMM
Wong SC,Chan AT,Lo ES,Lo YM
MA5-12717 was used in immunohistochemistry to study the association of nuclear beta-catenin with poor survival in colorectal signet-ring cell carcinoma
Thu Sep 01 00:00:00 EDT 2005
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a).
Oncogene
Faast R,White J,Cartwright P,Crocker L,Sarcevic B,Dalton S
MA5-12717 was used in western blot to study the resistance of embryonic stem cell Cdk6-cyclin D3 complexes to inhibition by p16(INK4a)
Thu Jan 15 00:00:00 EST 2004
Differential expression of d-type cyclins in podocytes in vitro and in vivo.
The American journal of pathology
Petermann A,Hiromura K,Pippin J,Blonski M,Couser WG,Kopp J,Mundel P,Shankland SJ
MA5-12717 was used in Immunohistochemistry to examine the glomerular expression of cyclins D1 and D3 in vitro, in cultured immortalised podocytes.
Thu Apr 01 00:00:00 EST 2004
Cyclin D3 is a predictive and prognostic factor in diffuse large B-cell lymphoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Filipits M,Jaeger U,Pohl G,Stranzl T,Simonitsch I,Kaider A,Skrabs C,Pirker R
MA5-12717 was used in immunohistochemistry to study the predictive and prognostic value of cyclin D3 in diffuse large B-cell lymphoma
Fri Mar 01 00:00:00 EST 2002
Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1.
The American journal of pathology
Gloghini A,Gaidano G,Larocca LM,Pierconti F,Cingolani A,Dal Maso L,Capello D,Franceschi S,Tirelli U,Libra M,Niu H,Dalla-Favera R,Carbone A
MA5-12717 was used in immunohistochemistry (paraffin) to examine the role of cell-cycle regulators in the pathogenesis of acquired immune deficiency syndrome-related non-Hodgkin's lymphomas.
Mon Jul 01 00:00:00 EDT 2002
In vivo interference with Skp1 function leads to genetic instability and neoplastic transformation.
Molecular and cellular biology
Piva R,Liu J,Chiarle R,Podda A,Pagano M,Inghirami G
MA5-12717 was used in immunoprecipitation to study the effect of loss of Skp1 function on genetic instability and neoplastic transformation in a transgenic mouse model
Sun Dec 01 00:00:00 EST 2002
Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.
Molecular and cellular biology
Tong W,Pollard JW
MA5-12717 was used in immunoprecipitation to study the interactions of cyclin D1 and p27(Kip1) using knockout mice
Thu Feb 01 00:00:00 EST 2001
Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms.
The Journal of cell biology
Servant MJ,Coulombe P,Turgeon B,Meloche S
MA5-12717 was used in Western Blotting to examine the downstream effects of platelet-derived growth factor-BB and Angiotensin II on regulators of the cell cycle machinery in rat aortic smooth muscle cells.
Mon Feb 07 00:00:00 EST 2000
Regulation of exit from quiescence by p27 and cyclin D1-CDK4.
Molecular and cellular biology
Ladha MH,Lee KY,Upton TM,Reed MF,Ewen ME
MA5-12717 was used in western blot to study the role of p27 and cyclin D1-CDK4 in regulating S-phase entry of quiescent NIH 3T3 cells
Sun Nov 01 00:00:00 EST 1998
Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma.
The American journal of pathology
Dei Tos AP,Piccinin S,Doglioni C,Vukosavljevic T,Mentzel T,Boiocchi M,Fletcher CD
MA5-12717 was used in immunohistochemistry to study the molecular biology of the G1-S cell cycle checkpoint in myxoid and round cell liposarcoma
Mon Dec 01 00:00:00 EST 1997