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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 224 and 492 of Human Cytochrome P450 1B1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
PA5-28040 targets Cytochrome P450 1B1 in IF applications and shows reactivity with Human samples.
The PA5-28040 immunogen is recombinant fragment corresponding to a region within amino acids 224 and 492 of Human Cytochrome P450 1B1.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Fumonisin B₁ modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b.
PA5-28040 was used in western blot to study the effect of FB1 on miR-27b suppression and its effect on CYP1B1 modulation in a human hepatoma cell line
|Chuturgoon AA,Phulukdaree A,Moodley D||Toxicology letters (227:50)||2014|
aryl hydrocarbon hydroxylase; benz[a]anthracene inducible; CP1B; CYPIB1; cytochrome P450; cytochrome P450 1B1; cytochrome P450, 1b1, benz[a]anthracene inducible; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); cytochrome P450CMEF; cytochrome P450EF; flavoprotein-linked monooxygenase; GLC3A; microsomal monooxygenase; P4501B1; polypeptide 1 (glaucoma 3; primary infantile); subfamily I (dioxin-inducible); xenobiotic monooxygenase
CP1B; Cyp1-b1; CYP1B1; CYPIB1; GLC3A; P4501B1