Peptide sequence: KHNQIITEET GSAVEPSDEI KRASGDVQTM KISSVPNSLS KRNVSLTRSH
Sequence homology: Cow: 85%; Dog: 86%; Guinea Pig: 79%; Horse: 85%; Human: 100%; Rabbit: 83%
DENND4C is guanine nucleotide exchange factor (GEF) activating RAB10. It promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DENN domain-containing protein 4C; DENN/MADD domain containing 4A pseudogene; DENN/MADD domain containing 4C
Gene Aliases: bA513M16.3; C9orf55; C9orf55B; DENND4C; RAB10GEF
UniProt ID: (Human) Q5VZ89
Entrez Gene ID: (Human) 55667