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Product Details
61002PROGEN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
DG 3.10
Immunogen
Band 3 Polypeptide Of Isolated Desmosomes From Bovine Muzzle Epidermis
Conjugate
Form
Lyophilized
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute lyophilized product with 1 mL distilled water.^M
^M
DG 3.10 recognizes desmoglein 1 + 2 (desmosome-specific cadherins) in desmosome-bearing cells; does not react with cells containing plaque-bearing junctions of non-desmosomal type. Tumors specifically detected: all epithelium-derived tumors, notably carcinomas, and meningiomas. Polypeptide reacting: MW 165 000 Desmoglein, "band 3" polypeptide of the desmosomal complex. Epitope recognized has been localized at the repeating unit domain ("RUD") of the cytoplasmic C-terminal part of the polypeptide.Reactivity on cultured cell lines: A-431, MDBK.
Target Information
DSG1 (Desmoglein 1) is a Protein Coding gene. Diseases associated with DSG1 include Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige and Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse. Among its related pathways are Keratinization and Apoptotic execution phase. Gene Ontology (GO) annotations related to this gene include calcium ion binding and toxic substance binding. An important paralog of this gene is DSG4. DSG2 (Desmoglein 2) is a Protein Coding gene. Diseases associated with DSG2 include Arrhythmogenic Right Ventricular Dysplasia, Familial, 10 and Cardiomyopathy, Dilated, 1Bb. Among its related pathways are Keratinization and Apoptotic execution phase. Gene Ontology (GO) annotations related to this gene include calcium ion binding and cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication. An important paralog of this gene is DSG4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 4; Cadherin family member 5; desmoglein 1; desmoglein 1 beta; desmoglein 1 gamma; desmoglein 2; Desmoglein-1; Desmoglein-2; Desmosomal glycoprotein 1; DG1; DGI; DSG1; DSG1/2; DSG2; HDGC; Pemphigus foliaceus antigen
Gene Aliases: CDHF4; CDHF5; DG1; DSG; DSG1; Dsg1b; Dsg1c; DSG2; EPKHE; EPKHIA; HDGC; PPKS1; SPPK1
UniProt ID: (Human) Q02413, (Bovine) Q03763, (Human) Q14126
Entrez Gene ID: (Human) 1828, (Bovine) 281131, (Human) 1829, (Bovine) 508151, (Rat) 291755, (Rat) 307562
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
single organismal cell-cell adhesion
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
response to progesterone
protein stabilization
maternal process involved in female pregnancy
desmosome organization
Purkinje myocyte development
cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell action potential
bundle of His cell to Purkinje myocyte communication
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