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ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Endoplasmic reticulum lipid raft-associated protein 2; Erlin-2; HGNC:1356; MGC87072; SPFH domain family, member 2; SPFH domain-containing protein 2; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; UNQ2441
Gene Aliases: BC036333; C87251; C8orf2; Erlin-2; ERLIN2; NET32; SPFH2; SPG18; UNQ2441/PRO5003/PRO9924
UniProt ID: (Human) O94905, (Mouse) Q8BFZ9
Entrez Gene ID: (Human) 11160, (Mouse) 244373
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