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Alomone Labs, LTD
Endothelin Receptor B Polyclonal Antibody
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FIGURE: 1 / 3
Endothelin Receptor B Antibody (AER-002-200UL) in IHC (P)
Expression of EDNRB in rat lung - Immunohistochemical staining of paraffin embedded section of rat lung using Anti-Endothelin Receptor B Antibody (#AER-002) (1:100). EDNRB is expressed both in respiratory epithelium (black arrows) and in respiratory smooth muscle (red arrows). Note that vascular smooth muscle is not stained (blue arrows).Hematoxilin is used as the counterstain.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
AER-002-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CEMLRKKSGMQIALND, corresponding to amino acid residues 298-314 of rat ET-B, 3rd intracellular loop
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
200 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AU022549; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor subtype B1; ET-B; Et-b receptor; Et-b-r; ET-BR; ET-RB; Etb receptor; Etb-svr; G-protein coupled receptor; Hirschsprung disease 2; piebald; RP11-318G21.1; unnamed protein product
Gene Aliases: ABCDS; Ednra; ET-B; ET-BR; ETB; ETB1; ETBR; ETR-b; ETRB; HSCR; HSCR2; Sox10m1; WS4A
UniProt ID: (Human) P24530, (Mouse) P48302, (Rat) P21451
Entrez Gene ID: (Human) 1910, (Mouse) 13618, (Rat) 50672
negative regulation of transcription from RNA polymerase II promoter
renin secretion into blood stream
regulation of heart rate
cGMP biosynthetic process
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
nervous system development
regulation of blood pressure
positive regulation of cell proliferation
gene expression
negative regulation of neuron maturation
vein smooth muscle contraction
vascular smooth muscle contraction
calcium-mediated signaling
melanocyte differentiation
regulation of fever generation
aldosterone metabolic process
response to lipopolysaccharide
enteric smooth muscle cell differentiation
positive regulation of urine volume
renal sodium excretion
epithelial fluid transport
vasoconstriction
vasodilation
negative regulation of apoptotic process
pigmentation
developmental pigmentation
macrophage chemotaxis
response to pain
enteric nervous system development
regulation of epithelial cell proliferation
negative regulation of protein metabolic process
sodium ion homeostasis
canonical Wnt signaling pathway
positive regulation of penile erection
renal sodium ion absorption
calcium ion transmembrane transport
cellular response to lipopolysaccharide
endothelin receptor signaling pathway
chordate pharynx development
response to sodium phosphate
response to endothelin
neural crest cell migration
positive regulation of protein phosphorylation
regulation of pH
peripheral nervous system development
posterior midgut development
blood circulation
heparin metabolic process
establishment of endothelial barrier
protein transmembrane transport
glomerular visceral epithelial cell differentiation
renal albumin absorption
renal system process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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