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Invitrogen
FOXA2 Monoclonal Antibody (7H4B7)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
MA5-15542
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7H4B7
Immunogen
Purified recombinant fragment of FOXA2 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_10979228
Product Specific Information
MA5-15542 targets FOXA2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15542 immunogen is purified recombinant fragment of FOXA2 expressed in E. Coli.
MA5-15542 detects FOXA2 which has a predicted molecular weight of approximately 48kDa.
Target Information
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN
Gene Aliases: FOXA2; Hnf-3b; HNF3-beta; HNF3B; HNF3beta; Tcf-3b; TCF3B
UniProt ID: (Human) Q9Y261, (Mouse) P35583
Entrez Gene ID: (Human) 3170, (Mouse) 15376
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
double-stranded DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
kinase binding
sequence-specific DNA binding
SMAD binding
winged helix/forkhead transcription factor
positive regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of transcription from RNA polymerase II promoter by glucose
cell fate specification
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
adult locomotory behavior
negative regulation of epithelial to mesenchymal transition
covalent chromatin modification
regulation of blood coagulation
endocrine pancreas development
negative regulation of glucokinase activity
positive regulation of embryonic development
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion involved in cellular response to glucose stimulus
response to interleukin-6
dopaminergic neuron differentiation
primitive streak formation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of gastrulation
negative regulation of detection of glucose
in utero embryonic development
ectoderm formation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
pattern specification process
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
regulation of gene expression
chromatin modification
regulation of lipid metabolic process
regulation of steroid metabolic process
cell differentiation in hindbrain
dorsal/ventral neural tube patterning
signal transduction involved in regulation of gene expression
lung development
somite rostral/caudal axis specification
negative regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of smoothened signaling pathway
positive regulation of transcription from RNA polymerase III promoter
cell development
anatomical structure formation involved in morphogenesis
neuron fate specification
epithelial tube branching involved in lung morphogenesis
lung epithelial cell differentiation
connective tissue development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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