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Product Details
TA500073
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3C10
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 300-458 of human FOXA2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN
Gene Aliases: FOXA2; HNF3B; TCF3B
UniProt ID: (Human) Q9Y261
Entrez Gene ID: (Human) 3170
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
protein domain specific binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
positive regulation of transcription from RNA polymerase II promoter by glucose
negative regulation of transcription from RNA polymerase II promoter by glucose
cell fate specification
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
adult locomotory behavior
negative regulation of epithelial to mesenchymal transition
covalent chromatin modification
regulation of blood coagulation
endocrine pancreas development
negative regulation of glucokinase activity
positive regulation of embryonic development
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion involved in cellular response to glucose stimulus
response to interleukin-6
dopaminergic neuron differentiation
primitive streak formation
positive regulation of cell-cell adhesion mediated by cadherin
positive regulation of gastrulation
negative regulation of detection of glucose
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