Product References
Tocilizumab-treated convalescent COVID-19 patients retain the cross-neutralization potential against SARS-CoV-2 variants.
iScience
Chauvin C,Levillayer L,Roumier M,Nielly H,Roth C,Karnam A,Bonam SR,Bourgarit A,Dubost C,Bousquet A,Le Burel S,Mestiri R,Sene D,Galland J,Vasse M,Groh M,Le Marchand M,Vassord-Dang C,Gautier JF,Pham-Thi N,Verny C,Pitard B,Planchais C,Mouquet H,Paul R,Simon-Loriere E,Bayry J,Gilardin L,Sakuntabhai A
17-4777-42 was used in Flow cytometry/Cell sorting to observe that SARS-CoV-2-specific IgG1 titers depended on disease severity but not on tocilizumab treatment.
Fri Mar 17 00:00:00 EDT 2023
Artificial intelligence-based immunoprofiling serves as a potentially predictive biomarker of nivolumab treatment for advanced hepatocellular carcinoma.
Frontiers in medicine
Lee JM,Hung YP,Chou KY,Lee CY,Lin SR,Tsai YH,Lai WY,Shao YY,Hsu C,Hsu CH,Chao Y
17-4777-42 was used in Flow cytometry/Cell sorting to evaluate whether dissecting peripheral immune cell subsets by Mann-Whitney U test and artificial intelligence (AI) algorithms could serve as predictive biomarkers of nivolumab treatment for advanced hepatocellular carcinoma (aHCC).
Sat Nov 26 00:00:00 EST 2022
Novel immunoprofiling method for diagnosing SLE and evaluating therapeutic response.
Lupus science & medicine
Lee JM,Chen MH,Chou KY,Chao Y,Chen MH,Tsai CY
17-4777-42 was used in Flow cytometry/Cell sorting to show that the comparison of immunprofiling between patients with SLE and HCs exhibited a distinct pattern. This difference and its application to immune signature algorithm shed light on the studies of SLE pathogenesis and immune-based diagnostic tool development in the future.
Wed Jun 01 00:00:00 EDT 2022
Mesenchymal stem cells transfer mitochondria to allogeneic Tregs in an HLA-dependent manner improving their immunosuppressive activity.
Nature communications
Piekarska K,Urban-Wójciuk Z,Kurkowiak M,Pelikant-Małecka I,Schumacher A,Sakowska J,Spodnik JH,Arcimowicz Ł,Zielińska H,Tymoniuk B,Renkielska A,Siebert J,Słomińska E,Trzonkowski P,Hupp T,Marek-Trzonkowska NM
17-4777-42 was used in Flow Cytometry to demonstrate that both direct and indirect contact with allogeneic ASCs improves therapeutic potential of Tregs (Regulatory T cells).
Mon Feb 14 00:00:00 EST 2022
MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis.
Journal of inflammation research
Liu Y,Zhao N,Xu Q,Deng F,Wang P,Dong L,Lu X,Xia L,Wang M,Chen Z,Zhou J,Zuo D
17-4777-42 was used in Flow cytometry/Cell sorting to suggest that MBL limited the Th17 immunity via controlling the AhR/STAT3 pathway, thus providing new insight into silicosis and other inflammatory diseases in patients with MBL deficiency.
Fri Aug 05 00:00:00 EDT 2022
FOXP3 protects conventional human T cells from premature restimulation-induced cell death.
Cellular & molecular immunology
Voss K,Lake C,Luthers CR,Lott NM,Dorjbal B,Arjunaraja S,Bauman BM,Soltis AR,Sukumar G,Dalgard CL,Snow AL
17-4777 was used in Flow cytometry/Cell sorting to describe a novel role for FOXP3 in protecting human Tcons from premature RICD during expansion.
Fri Jan 01 00:00:00 EST 2021
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients.
Frontiers in cell and developmental biology
Hu Y,Chen Y,Chen Z,Zhang X,Guo C,Yu Z,Xu P,Sun L,Zhou X,Gong Y,Yu Q,Shi Y
17-4777-42 was used in Flow cytometry/Cell sorting to explore the expression of iNKT cells in psoriasis patients and the effect of secukinumab on them.
Wed Feb 23 00:00:00 EST 2022
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
17-4777-42 was used in Flow cytometry/Cell sorting to explore the antimetastatic effect and immunomodulatory function of a clinical formula Aiduqing (ADQ).
Mon Aug 30 00:00:00 EDT 2021
KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia.
ImmunoHorizons
Izumi K,Shindo T,Ngo HT,Nakayama-Hosoya K,Akahane K,Tamai M,Nguyen TTT,Kawana-Tachikawa A,Inukai T,Takaori-Kondo A
17-4777-42 was used in Flow cytometry/Cell sorting to investigate differential NK cell activity modulation through different KIR3DL1 allotypes.
Wed Aug 25 00:00:00 EDT 2021
Accumulation of TNFR2-expressing regulatory T cells in malignant pleural effusion of lung cancer patients is associated with poor prognosis.
Annals of translational medicine
Ye LL,Peng WB,Niu YR,Xiang X,Wei XS,Wang ZH,Wang X,Zhang SY,Chen X,Zhou Q
17-4777 was used in Flow cytometry/Cell sorting to investigate associations between TNFR2+Tregs frequencies present in malignant pleural effusion and the clinical and laboratorial characteristics of patients with lung cancer.
Tue Dec 01 00:00:00 EST 2020
Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.
The Journal of international medical research
He J,Xu Y,Yi M,Gu C,Zhu Y,Hu G
17-4777 was used in Flow cytometry/Cell sorting to investigate the involvement of immune cells in the pathogenesis of endometriosis progression by analyzing blood samples from patients with stable disease and those with pelvic pain.
Wed Jul 01 00:00:00 EDT 2020
CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
JCI insight
Imura Y,Ando M,Kondo T,Ito M,Yoshimura A
17-4777 was used in Flow cytometry/Cell sorting to suggest that CD19-CAR regulatory T cells can treat autoantibody-mediated autoimmune diseases by suppressing B cell pathology.
Thu Jul 23 00:00:00 EDT 2020
Investigation of the PD-1 and PD-L1 Immune Checkpoint Molecules Throughout Healthy Human Pregnancy and in Nonpregnant Women.
Journal of clinical medicine
Meggyes M,Nagy DU,Szereday L
17-4777 was used in Flow cytometry/Cell sorting to understand the peripheral expression of PD-1 and PD-L1 during the trimesters of pregnancy and in non-pregnant women.
Thu Aug 06 00:00:00 EDT 2020
Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphoma.
Oncoimmunology
Blümel E,Munir Ahmad S,Nastasi C,Willerslev-Olsen A,Gluud M,Fredholm S,Hu T,Surewaard BGJ,Lindahl LM,Fogh H,Koralov SB,Rahbek Gjerdrum LM,Clark RA,Iversen L,Krejsgaard T,Bonefeld CM,Geisler C,Becker JC,Woetmann A,Andersen MH,Buus TB,Ødum N
17-4777 was used in Flow cytometry/Cell sorting to propose a novel mechanism by which colonization with Staphylococcus aureus may contribute to cancer immune evasion and disease progression in cutaneous T-cell lymphoma (CTCL).
Wed Jul 14 00:00:00 EDT 2021
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
17-4777 was used in Flow cytometry/Cell sorting to investigate how mouse double minute 2 homolog effects the function of regulatory T cells.
Mon Apr 05 00:00:00 EDT 2021
Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells.
Methods in molecular biology (Clifton, N.J.)
Hou TZ,Qureshi OS,Sansom DM
17-4777-42 was used in Flow cytometry/Cell sorting to provide protocols for isolation of human monocytes and their differentiation into dendritic cells (DC), purification of conventional and regulatory T-cell populations, and the assembly of CTLA-4-dependent Treg suppression assays.
Mon Jun 10 00:00:00 EDT 2019
A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nature medicine
Trotta E,Bessette PH,Silveria SL,Ely LK,Jude KM,Le DT,Holst CR,Coyle A,Potempa M,Lanier LL,Garcia KC,Crellin NK,Rondon IJ,Bluestone JA
17-4777 was used in Flow cytometry/Cell sorting to suggest that IL-2-F5111.2 may provide an immunotherapy to treat autoimmune diseases and graft-versus-host disease.
Sun Jul 01 00:00:00 EDT 2018
Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection.
Hepatology (Baltimore, Md.)
Cobb DA,Kim OK,Golden-Mason L,Rosen HR,Hahn YS
17-4777 was used in Flow cytometry/Cell sorting to examine the accumulation of Tfr cells in the liver compartment during chronic HCV infection and defined the cellular and molecular mechanisms underlying their expansion.
Mon Jan 01 00:00:00 EST 2018
Allergen-specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model.
Allergy
Shin JU,Kim SH,Noh JY,Kim JH,Kim HR,Jeong KY,Park KH,Lee J,Chu H,Lee JH,Yong TS,Park JW,Lee KH
17-4777-42 was used in flow cytometry to suggest an SIT model is a useful tool to investigate mechanism of action of SIT and to validate the efficacy of new SIT modalities for the treatment of AD.
Sat Sep 01 00:00:00 EDT 2018
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.
BMC biology
Schmidt A,Marabita F,Kiani NA,Gross CC,Johansson HJ,Éliás S,Rautio S,Eriksson M,Fernandes SJ,Silberberg G,Ullah U,Bhatia U,Lähdesmäki H,Lehtiö J,Gomez-Cabrero D,Wiendl H,Lahesmaa R,Tegnér J
Mon May 07 00:00:00 EDT 2018
A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.
Experimental gerontology
Kraig E,Linehan LA,Liang H,Romo TQ,Liu Q,Wu Y,Benavides AD,Curiel TJ,Javors MA,Musi N,Chiodo L,Koek W,Gelfond JAL,Kellogg DL
17-4777-42 was used in Flow cytometry/Cell sorting to demonstrate that short-term RAPA treatment appeared safe, with no significant adverse effects on metabolism, cognitive function, physical performance, or immune parameters.
Tue May 01 00:00:00 EDT 2018
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Blood
Hou TZ,Verma N,Wanders J,Kennedy A,Soskic B,Janman D,Halliday N,Rowshanravan B,Worth A,Qasim W,Baxendale H,Stauss H,Seneviratne S,Neth O,Olbrich P,Hambleton S,Arkwright PD,Burns SO,Walker LS,Sansom DM
17-4777 was used in Flow cytometry/Cell sorting to develop assays capable of distinguishing a variety of defects in the CTLA-4 pathway.
Thu Mar 16 00:00:00 EDT 2017
Monomeric Immunoglobulin A from Plasma Inhibits Human Th17 Responses In Vitro Independent of FcαRI and DC-SIGN.
Frontiers in immunology
Saha C,Das M,Patil V,Stephen-Victor E,Sharma M,Wymann S,Jordi M,Vonarburg C,Kaveri SV,Bayry J
17-4777 was used in Flow cytometry/Cell sorting to suggest the potential therapeutic utility of monomeric IgA in autoimmune and inflammatory diseases that implicate Th17 cells.
Wed Nov 20 00:00:00 EST 2019
Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells.
Frontiers in immunology
Joshi RN,Binai NA,Marabita F,Sui Z,Altman A,Heck AJR,Tegnér J,Schmidt A
17-4777 was used in Flow cytometry/Cell sorting to investigate Treg suppression mechanisms.
Mon Jan 31 00:00:00 EST 2022
T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.
The Journal of clinical investigation
Patterson SJ,Pesenacker AM,Wang AY,Gillies J,Mojibian M,Morishita K,Tan R,Kieffer TJ,Verchere CB,Panagiotopoulos C,Levings MK
17-4777 was used in Flow cytometry/Cell sorting to investigate how Treg-to-target proximity is controlled.
Tue Mar 01 00:00:00 EST 2016
TGF-β Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
Frontiers in immunology
Éliás S,Schmidt A,Kannan V,Andersson J,Tegnér J
17-4777 was used in Flow cytometry/Cell sorting to study the environmental cues that promote differentiation of granulocyte-macrophage colony-stimulating factor producing T cells.
Wed Nov 20 00:00:00 EST 2019
IL-1β, But Not Programed Death-1 and Programed Death Ligand Pathway, Is Critical for the Human Th17 Response to Mycobacterium tuberculosis.
Frontiers in immunology
Stephen-Victor E,Sharma VK,Das M,Karnam A,Saha C,Lecerf M,Galeotti C,Kaveri SV,Bayry J
17-4777 was used in Flow cytometry/Cell sorting to investigate the role of PD pathway in regulating Th17 response to M. tuberculosis, showing that IL-1β, but not that PD-1 pathway, is critical for response.
Wed Nov 20 00:00:00 EST 2019
Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?
PloS one
Stikvoort A,Sundin M,Uzunel M,Gertow J,Sundberg B,Schaffer M,Mattsson J,Uhlin M
17-4777 was used in Flow cytometry/Cell sorting to study how the populations of NKT-cells differs following hematopoietic stem cell transplantation according to whether a patient retains any of their own immune cells or not.
Mon Jul 17 00:00:00 EDT 2017
Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate.
PloS one
Schmidt A,Eriksson M,Shang MM,Weyd H,Tegnér J
17-4777 was used in Flow cytometry/Cell sorting to develop novel protocols for human iTreg generation using TGF-β in combination with other compounds.
Wed Jul 20 00:00:00 EDT 2016
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
PloS one
Goldstein JD,Burlion A,Zaragoza B,Sendeyo K,Polansky JK,Huehn J,Piaggio E,Salomon BL,Marodon G
17-4777 was used in Flow cytometry/Cell sorting to investigate the role of the JAK/STAT pathway in controlling Foxp3 in the short term, showing dynamic regulation of Foxp3 expression.
Thu Aug 25 00:00:00 EDT 2016
PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.
PloS one
Jones K,Ballesteros A,Mentink-Kane M,Warren J,Rattila S,Malech H,Kang E,Dveksler G
17-4777 was used in Flow cytometry/Cell sorting to investigate whether pregnancy-specific glycoprotein 9, a potential predictive biomarker of pre-eclampsia, plays an immunoregulatory role during pregnancy.
Wed Jul 26 00:00:00 EDT 2017
IL-34 is a Treg-specific cytokine and mediates transplant tolerance.
The Journal of clinical investigation
Bézie S,Picarda E,Ossart J,Tesson L,Usal C,Renaudin K,Anegon I,Guillonneau C
17-4777-42 was used in Flow cytometry/Cell sorting to identify that IL-34 serves as a suppressive regulatory T cell-specific cytokine and as a tolerogenic cytokine that efficiently inhibits alloreactive immune responses and mediates transplant tolerance.
Thu Oct 01 00:00:00 EDT 2015
Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Tonsho M,Lee S,Aoyama A,Boskovic S,Nadazdin O,Capetta K,Smith RN,Colvin RB,Sachs DH,Cosimi AB,Kawai T,Madsen JC,Benichou G,Allan JS
17-4777 was used in Flow cytometry/Cell sorting to report durable mixed chimerism and successful tolerance induction of MHC-mismatched lungs in primates.
Sat Aug 01 00:00:00 EDT 2015
Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Giannakopoulou E,Lom H,Wedderburn LR
17-4777 was used in Flow cytometry/Cell sorting to identify a unique population of Treg cells which arise from separate lineages to conventional T cells in response to chronic inflammatory conditions.
Tue Dec 15 00:00:00 EST 2015
Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer: A randomized, placebo-controlled, phase 1 trial.
Oncoimmunology
Schmitz-Winnenthal FH,Hohmann N,Niethammer AG,Friedrich T,Lubenau H,Springer M,Breiner KM,Mikus G,Weitz J,Ulrich A,Buechler MW,Pianka F,Klaiber U,Diener M,Leowardi C,Schimmack S,Sisic L,Keller AV,Koc R,Springfeld C,Knebel P,Schmidt T,Ge Y,Bucur M,Stamova S,Podola L,Haefeli WE,Grenacher L,Beckhove P
17-4777 was used in Flow cytometry/Cell sorting to demonstrate that VXM01 elicits a productive, complex VEGFR2 specific T effector cell response in patients with pancreatic cancer.
Wed Apr 01 00:00:00 EDT 2015
GITR engagement in combination with CTLA-4 blockade completely abrogates immunosuppression mediated by human liver tumor-derived regulatory T cells ex vivo.
Oncoimmunology
Pedroza-Gonzalez A,Zhou G,Singh SP,Boor PP,Pan Q,Grunhagen D,de Jonge J,Tran TK,Verhoef C,IJzermans JN,Janssen H,Biermann K,Kwekkeboom J,Sprengers D
17-4777 was used in Flow cytometry/Cell sorting to investigate the ability of GITR-ligation and CTLA-4 blockade treatments to alleviate immunosuppression mediated by human liver tumor-derived regulatory T cells.
Tue Dec 01 00:00:00 EST 2015
High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment.
British journal of cancer
Ma GF,Miao Q,Liu YM,Gao H,Lian JJ,Wang YN,Zeng XQ,Luo TC,Ma LL,Shen ZB,Sun YH,Chen SY
17-4777 was used in Flow cytometry/Cell sorting to study role of Forkhead Box P3 expression in gastric cancer, and the underlying mechanisms regulating the interaction between gastric cancer cells and lymphocytes.
Tue Mar 18 00:00:00 EDT 2014
Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Pesenacker AM,Ursu S,Wu Q,Lom H,Thirugnanabalan B,Wedderburn LR
17-4777 was used in Flow cytometry/Cell sorting to study dissociation of CD25 and FOXP3 in CD4+ T cells at the site of inflammation in patients with juvenile arthritis..
Mon Sep 15 00:00:00 EDT 2014
Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.
International journal of cancer
Huen NY,Pang AL,Tucker JA,Lee TL,Vergati M,Jochems C,Intrivici C,Cereda V,Chan WY,Rennert OM,Madan RA,Gulley JL,Schlom J,Tsang KY
17-4777 was used in Flow cytometry/Cell sorting to perform genome-wide expression analyses to compare gene expression in Tregs isolated from the peripheral blood of healthy donors and patients with metastatic castration-resistant prostate cancer.
Mon Jul 15 00:00:00 EDT 2013
CD25 and TNF receptor II reflect early primary response to infliximab therapy in patients with ulcerative colitis.
United European gastroenterology journal
Magnusson MK,Dahlén R,Strid H,Isaksson S,Simrén M,Lasson A,Bajor A,Ung KA,Ohman L
17-4777 was used in Flow cytometry/Cell sorting to demonstrate that T-cell phenotype and sCD25 and sTNFRII serum levels are potential biomarkers of therapy response against ulcerative.
Sun Dec 01 00:00:00 EST 2013
Neuropilin-1 expression characterizes T follicular helper (Tfh) cells activated during B cell differentiation in human secondary lymphoid organs.
PloS one
Renand A,Milpied P,Rossignol J,Bruneau J,Lemonnier F,Dussiot M,Coulon S,Hermine O
17-4777 was used in Flow cytometry/Cell sorting to characterise Nrp1-expressing T cells in human secondary lymphoid organs.
Mon Feb 23 00:00:00 EST 2015
Myeloid cells obtained from the blood but not from the tumor can suppress T-cell proliferation in patients with melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Gros A,Turcotte S,Wunderlich JR,Ahmadzadeh M,Dudley ME,Rosenberg SA
17-4777 was used in Flow cytometry/Cell sorting to provide a first characterization of the nature and suppressive function of the melanoma myeloid infiltrate.
Mon Oct 01 00:00:00 EDT 2012
Early and long-lasting alteration of effector CD45RA(-)Foxp3(high) regulatory T-cell homeostasis during HIV infection.
The Journal of infectious diseases
Simonetta F,Lecuroux C,Girault I,Goujard C,Sinet M,Lambotte O,Venet A,Bourgeois C
17-4777 was used in Flow cytometry/Cell sorting to demonstrate that effector but not total or naive Treg numbers were negatively correlated with the magnitude of HIV-specific CD8 T-cell responses.
Tue May 15 00:00:00 EDT 2012
Role of porcine reproductive and respiratory syndrome virus nucleocapsid protein in induction of interleukin-10 and regulatory T-lymphocytes (Treg).
The Journal of general virology
Wongyanin P,Buranapraditkul S,Yoo D,Thanawongnuwech R,Roth JA,Suradhat S
17-4777 was used in Flow cytometry/Cell sorting to reveal an immunomodulatory function of the porcine reproductive and respiratory syndrome virus (PRRSV) N protein that may contribute to the unique infection.
Fri Jun 01 00:00:00 EDT 2012
Characterizing T cells in SCID patients presenting with reactive or residual T lymphocytes.
Clinical & developmental immunology
Lev A,Simon AJ,Trakhtenbrot L,Goldstein I,Nagar M,Stepensky P,Rechavi G,Amariglio N,Somech R
17-4777 was used in Flow cytometry/Cell sorting to compare and characterise T cell functions in several immunodeficiency subtypes, clinically presenting with nonreactive residual cells or reactive cells.
Mon Aug 12 00:00:00 EDT 2013
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.
Gastroenterology
Hovhannisyan Z,Treatman J,Littman DR,Mayer L
17-4777 was used in Flow cytometry/Cell sorting to investigate how Th17 and Tregs interact under chronic inflammatory conditions.
Tue Mar 01 00:00:00 EST 2011
Uncoupling of proliferation and cytokines from suppression within the CD4+CD25+Foxp3+ T-cell compartment in the 1st year of human type 1 diabetes.
Diabetes
Hughson A,Bromberg I,Johnson B,Quataert S,Jospe N,Fowell DJ
17-4777 was used in Flow cytometry/Cell sorting to determine the relative proportions of effector and regulatory T cells in the CD4+CD25+Foxp3+ T-cell compartment in varying type 1 diabetes disease states.
Mon Aug 01 00:00:00 EDT 2011
Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination.
Cancer immunology, immunotherapy : CII
Vergati M,Cereda V,Madan RA,Gulley JL,Huen NY,Rogers CJ,Hance KW,Arlen PM,Schlom J,Tsang KY
17-4777 was used in Flow cytometry/Cell sorting to highlight a possible association between improved overall survival and a decrease in Treg function after three monthly vaccinations.
Tue Feb 01 00:00:00 EST 2011
Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells.
Vaccine
Cereda V,Vergati M,Huen NY,di Bari MG,Jochems C,Intrivici C,Gulley JL,Apelian D,Schlom J,Tsang KY
17-4777 was used in Flow cytometry/Cell sorting to assess the contribution of yeast-treated dendritic cells to the induction of regulatory and effector T cells.
Tue Jul 12 00:00:00 EDT 2011
Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.
Science translational medicine
Poirier N,Azimzadeh AM,Zhang T,Dilek N,Mary C,Nguyen B,Tillou X,Wu G,Reneaudin K,Hervouet J,Martinet B,Coulon F,Allain-Launay E,Karam G,Soulillou JP,Pierson RN,Blancho G,Vanhove B
17-4777 was used in Immunohistochemistry to suggest that targeting costimulation blockade at CD28 favors CTLA-4-dependent immune regulation and promotes allograft survival.
Wed Feb 03 00:00:00 EST 2010
Role played by CD4+FOXP3+ regulatory T Cells in suppression of host responses to Haemophilus ducreyi during experimental infection of human volunteers.
The Journal of infectious diseases
Li W,Tenner-Racz K,Racz P,Janowicz DM,Fortney KR,Katz BP,Spinola SM
17-4777 was used in Flow cytometry/Cell sorting to propose that the population of CD4(+)CD25(+)CD127(lo/-)FOXP3(+) T(reg) cells are expanded at H. ducreyi-infected sites and may supress the hosts immune response.
Tue Jun 15 00:00:00 EDT 2010
CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection.
The Journal of infectious diseases
Green AM,Mattila JT,Bigbee CL,Bongers KS,Lin PL,Flynn JL
Sun Aug 15 00:00:00 EDT 2010
De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Wang J,Huizinga TW,Toes RE
17-4777 was used in Flow cytometry/Cell sorting to investigate methods to convert T cells into Treg cells, showing that retinoic acid can be used for de novo generation of Tregs.
Tue Sep 15 00:00:00 EDT 2009
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
The Journal of clinical investigation
Klatt NR,Villinger F,Bostik P,Gordon SN,Pereira L,Engram JC,Mayne A,Dunham RM,Lawson B,Ratcliffe SJ,Sodora DL,Else J,Reimann K,Staprans SI,Haase AT,Estes JD,Silvestri G,Ansari AA
17-4777 was used in Flow cytometry/Cell sorting to elucidate the factors dictating viremia in naturally SIV-infected sooty mangabeys, most importantly, the level of proliferating CD4+ T cells, which was correlated with viral replication.
Sun Jun 01 00:00:00 EDT 2008
Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus.
Rheumatology (Oxford, England)
Lee HY,Hong YK,Yun HJ,Kim YM,Kim JR,Yoo WH
17-4777 was used in Flow cytometry/Cell sorting to suggest that altered Treg frequency and decreased Treg migratory capacity may be involved in the pathogenesis of systemic lupus erythematosus.
Sun Jun 01 00:00:00 EDT 2008
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950)
Estes JD,Gordon SN,Zeng M,Chahroudi AM,Dunham RM,Staprans SI,Reilly CS,Silvestri G,Haase AT
Thu May 15 00:00:00 EDT 2008
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.
International immunology
Passerini L,Allan SE,Battaglia M,Di Nunzio S,Alstad AN,Levings MK,Roncarolo MG,Bacchetta R
17-4777 was used in Flow cytometry/Cell sorting to investigate whether activated T effector cells expresses Foxp3.
Sat Mar 01 00:00:00 EST 2008
Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells.
International immunology
Nagar M,Vernitsky H,Cohen Y,Dominissini D,Berkun Y,Rechavi G,Amariglio N,Goldstein I
17-4777 was used in Flow cytometry/Cell sorting to investigate the mode of de novo activation-dependent expression of FOXP3 in conventional human CD4+ T cells.
Fri Aug 01 00:00:00 EDT 2008
