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FYN Monoclonal Antibody (1G4B1)

View all (26) Fyn antibodies

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FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 66606-1-Ig (FYN antibody) at dilution of 1:5000 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 66606-1-Ig (FYN antibody) at dilution of 1:5000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 66606-1-IG (FYN antibody) at dilution of 1:500 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 66606-1-IG (FYN antibody) at dilution of 1:500 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 66606-1-Ig (FYN antibody) at dilution of 1:5000 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 66606-1-Ig (FYN antibody) at dilution of 1:5000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

FYN Antibody in Western Blot (WB) — NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 66606-1-Ig (FYN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

FYN Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 66606-1-Ig (FYN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

FYN Antibody in Western Blot (WB) — HSC-T6 cells were subjected to SDS PAGE followed by western blot with 66606-1-Ig (FYN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

FYN Antibody in Western Blot (WB) — Jurkat cells were subjected to SDS PAGE followed by western blot with 66606-1-Ig (FYN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

FYN Antibody in Western Blot (WB) — MCF-7 cells were subjected to SDS PAGE followed by western blot with 66606-1-Ig (FYN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

FYN Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 66606-1-IG (FYN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1000

-

Western Blot (WB)

1:2000-1:10,000

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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host / Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1G4B1

Immunogen

FYN Fusion Protein Ag11127

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Target Information

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; fyn {ECO:0000312|RGD:2641}; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn

Gene Aliases: AI448320; AW552119; FYN; p59-FYN; SLK; SYN

UniProt ID: (Human) P06241, (Rat) Q62844, (Mouse) P39688

Entrez Gene ID: (Human) 2534, (Rat) 25150, (Mouse) 14360

Molecular Function: kinase non-receptor tyrosine protein kinase protein kinase transferase

MAPK cascade neuron migration stimulatory C-type lectin receptor signaling pathway adaptive immune response protein phosphorylation calcium ion transport transmembrane receptor protein tyrosine kinase signaling pathway axon guidance central nervous system development blood coagulation learning feeding behavior regulation of cell shape negative regulation of gene expression positive regulation of neuron projection development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling viral process cell migration peptidyl-tyrosine phosphorylation cell differentiation platelet activation forebrain development T cell costimulation negative regulation of protein ubiquitination intracellular signal transduction cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis T cell activation regulation of cell proliferation negative regulation of protein catabolic process response to drug positive regulation of tyrosine phosphorylation of Stat5 protein regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity innate immune response response to ethanol phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling dendrite morphogenesis regulation of defense response to virus by virus activated T cell proliferation T cell receptor signaling pathway leukocyte migration detection of mechanical stimulus involved in sensory perception of pain cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus positive regulation of protein localization to nucleus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand cell surface receptor signaling pathway ionotropic glutamate receptor signaling pathway protein autophosphorylation cellular response to growth factor stimulus immune system process multicellular organism development phosphorylation myelination

Process(es)

G-protein coupled receptor binding glycoprotein binding protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding tubulin binding T cell receptor binding CD4 receptor binding CD8 receptor binding phosphatidylinositol 3-kinase binding ion channel binding metal ion binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity peptide hormone receptor binding growth factor receptor binding protein kinase activity receptor binding protein complex binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups