Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
66606-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G4B1
Immunogen
FYN Fusion Protein Ag11127 (231-483 aa encoded by BC032496)
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: YSGTWNGNT KVAIKTLKPG TMSPESFLEE AQIMKKLKHD KLVQLYAVVS EEPIYIVTEY MNKGSLLDFL KDGEGRALKL PNLVDMAAQV AAGMAYIERM NYIHRDLRSA NILVGNGLIC KIADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELVTKGR VPYPGMNNRE VLEQVERGYR MPCPQDCPIS LHELMIHCWK KDPEERPTFE YLQSFLEDYF TATEPQYQPG ENL (231-483 aa encoded by BC032496)
Target Information
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; fyn {ECO:0000312|RGD:2641}; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn
Gene Aliases: AI448320; AW552119; FYN; p59-FYN; SLK; SYN
UniProt ID: (Human) P06241, (Rat) Q62844, (Mouse) P39688
Entrez Gene ID: (Human) 2534, (Rat) 25150, (Mouse) 14360
Molecular Function:
kinase modulator
MAPK cascade
neuron migration
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
protein phosphorylation
calcium ion transport
transmembrane receptor protein tyrosine kinase signaling pathway
axon guidance
central nervous system development
blood coagulation
learning
feeding behavior
regulation of cell shape
negative regulation of gene expression
positive regulation of neuron projection development
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
platelet activation
forebrain development
T cell costimulation
negative regulation of protein ubiquitination
intracellular signal transduction
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell activation
regulation of cell proliferation
negative regulation of protein catabolic process
response to drug
positive regulation of tyrosine phosphorylation of Stat5 protein
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
innate immune response
response to ethanol
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
dendrite morphogenesis
regulation of defense response to virus by virus
activated T cell proliferation
T cell receptor signaling pathway
leukocyte migration
detection of mechanical stimulus involved in sensory perception of pain
cellular response to peptide hormone stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of protein localization to nucleus
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell surface receptor signaling pathway
ionotropic glutamate receptor signaling pathway
protein autophosphorylation
cellular response to growth factor stimulus
immune system process
multicellular organism development
phosphorylation
myelination
G-protein coupled receptor binding
glycoprotein binding
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
tubulin binding
T cell receptor binding
CD4 receptor binding
CD8 receptor binding
phosphatidylinositol 3-kinase binding
ion channel binding
metal ion binding
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
peptide hormone receptor binding
growth factor receptor binding
protein kinase activity
receptor binding
protein complex binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support