Fibromodulin is a member of a family of small interstitial proteoglycans, containing a central region composed of leucine-rich repeats with 4 keratan sulfate chains flanked by disulfide-bonded terminal domains. It may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix.
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Protein Aliases: Collagen-binding 59 kDa protein; Fibromodulin; FM; Keratan sulfate proteoglycan fibromodulin; KSPG fibromodulin
Gene Aliases: FM; FMOD; SLRR2E
UniProt ID: (Human) Q06828
Entrez Gene ID: (Human) 2331