This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: CESGIHNCLP DFICQNTLGS FRCRPKLQCK SGFIQDALGN CIDINECLSI SAPCPIGHTC INTEGSYTCQ KNVPNCGRGY HLNEEGTRCV DVDECAPPAE PCGKGHRCVN SPGSFRCECK TGYYFDGISR MCVDVNE
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FIBL-1; Fibulin-1; Fibulin1
Gene Aliases: FBLN; FBLN1; FIBL1; PP213
UniProt ID: (Human) P23142
Entrez Gene ID: (Human) 2192