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|Tested species reactivity||Human|
|Published species reactivity||Primate, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the mid region of the human Furin protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells.
36-1800 was used in western blot to investigate the effect of antimesothelin immunotoxin SS1P and BH3-mimetic ABT-737 on SS1P-resistant pancreatic cancer cells
|Hollevoet K,Antignani A,Fitzgerald DJ,Pastan I||Journal of immunotherapy (Hagerstown, Md. : 1997) (37:8)||2014|
|Mouse||Not Cited||Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.||Gagnon J,Mayne J,Mbikay M,Woulfe J,Chrétien M||Regulatory peptides (152:54)||2009|
||Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine.||Gagnon J,Mayne J,Mbikay M,Woulfe J,Chrétien M||Regulatory peptides (152:54)||2009|
|Primate||Not Cited||Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.||Kimura N,Yanagisawa K||Neuroreport (18:1669)||2007|
dibasic processing enzyme; FES upstream region; Fur; furin (paired basic amino acid cleaving enzyme); furin convertase; furin, membrane associated receptor protein; PACE; paired basic amino acid residue-cleaving enzyme; Pcsk3; proprotein convertase subtilisin/kexin type 3; SPC1
FUR; FURIN; PACE; PCSK3; SPC1