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Immunogen sequence: MLEPALATG EELPELTLLT TLLEGPGDKT QPPEEETLSQ APESEEEQKK KALERSMYVL SELVETEKMY VDDLGQIVEG YMATMAAQGV PESLRGRDRI VFGNIQQIYE WHRDYFLQEL QRCLKDPDWL AQLFIKHERR LHMYVVYCQN KPKSEHVVSE FGDSYFEELR QQLGHRLQLN DLLIKPVQRI MKYQLLLKDF LKYYNRAGMD TADLEQAVEV MCFVPKRCND MMTLGRLRGF EGKLTAQGKL LGQDTFWVTE PEAGGLLSSR GRERRVFLFE QIIIFSEALG GGVRGGTQPG YVYKNSIKVS CLGLEGNLQG DPCRFALTSR GPEGGIQRYV LQAADPAISQ (1-349 aa encoded by BC012860)
The Rho family of small GTPases act as molecular switches to control a wide range of cellular processes. Guanine nucleotide exchange factors (GEFs), like GEFT, activate Rho GTPases by accelerating GDP/GTP exchange. The Rho family of small GTPases act as molecular switches to control a wide range of cellular processes. Guanine nucleotide exchange factors (GEFs), like GEFT, activate Rho GTPases by accelerating GDP/GTP exchange (Souchet et al., 2002 ).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Guanine nucleotide exchange factor GEFT; p63RhoGEF; RAC/CDC42 exchange factor; Rac/Cdc42/Rho exchange factor GEFT; Rho guanine nucleotide exchange factor (GEF) 25; Rho guanine nucleotide exchange factor 25; RhoA/RAC/CDC42 exchange factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
Gene Aliases: 2410008H17Rik; ARHGEF25; D10Ertd610e; GEFT; p63RhoGEF
UniProt ID: (Human) Q86VW2, (Mouse) Q9CWR0, (Rat) Q6P720
Entrez Gene ID: (Rabbit) 100339852, (Pig) 100517400, (Human) 115557, (Mouse) 52666, (Rat) 314904
Molecular Function:
guanyl-nucleotide exchange factor
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