Invitrogen
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
- | View 3 publications 3 publications |
Immunohistochemistry (IHC) |
- | View 2 publications 2 publications |
Immunocytochemistry (ICC/IF) |
1-10 µg/mL | View 1 publication 1 publication |
Immunoprecipitation (IP) |
- | View 2 publications 2 publications |
ChIP assay (ChIP) |
- | View 4 publications 4 publications |
Product Specifications | |
---|---|
Species Reactivity |
Dog, Hamster, Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1 |
Conjugate |
Alexa Fluor™ 488 |
Excitation/Emission Profile |
View spectra |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.4, with 1mg/mL BSA |
Contains |
0.05% sodium azide |
Storage conditions |
4° C, store in dark, DO NOT FREEZE! |
RRID |
AB_2662019 |
PA1860A488 detects histone deacetylase 1 (HDAC1) from human, mouse, rat, hamster and canine tissues and cells.
The PA1860A488 immunogen is a synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1. This immunizing peptide (Cat. # PEP-069) is available for use in neutralization and control experiments.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686H12203; HD1; Histone deacetylase 1; histone deacetylase 1-like protein; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2
Gene Aliases: GON-10; HD1; HDAC1; Hdac1-ps; MommeD5; RPD3; RPD3L1
UniProt ID: (Human) Q13547, (Mouse) O09106, (Rat) Q4QQW4
Entrez Gene ID: (Human) 3065, (Dog) 487309, (Mouse) 433759, (Rat) 297893, (Chinese hamster) 100752721
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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