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Invitrogen

HDAC4 Monoclonal Antibody (5E4A5)

View all (53) HDAC4 antibodies

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HDAC4 Monoclonal Antibody (5E4A5)

Product Details

MA5-38537

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5E4A5

Immunogen

Purified recombinant fragment of human HDAC4 (aa: 456-592) expressed in E. Coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898449

Product Specific Information

This antibody has been tested in indirect ELISA.

Target Information

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp779K1053; HD7; HD7b; HD9; HDAC; HDAC4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; histone deacetylase A; KIAA0744; MITR; unnamed protein product

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Gene Aliases: 4932408F19Rik; AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDACA; NEDCHF; NEDCHID

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UniProt ID: (Human) P56524, (Mouse) Q6NZM9

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Entrez Gene ID: (Human) 9759, (Mouse) 208727

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding SUMO transferase activity potassium ion binding protein deacetylase activity histone binding identical protein binding histone deacetylase binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism DNA binding chromatin binding transcription corepressor activity protein kinase binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin remodeling inflammatory response nervous system development positive regulation of cell proliferation negative regulation of myotube differentiation response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress protein sumoylation B cell differentiation positive regulation of protein sumoylation regulation of gene expression, epigenetic B cell activation negative regulation of gene expression, epigenetic negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway negative regulation of protein refolding response to interleukin-1 skeletal system development osteoblast development negative regulation of cell proliferation response to xenobiotic stimulus positive regulation of lamellipodium assembly regulation of cardiac muscle contraction by calcium ion signaling positive regulation of smooth muscle cell migration positive regulation of neuron apoptotic process negative regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development regulation of striated muscle cell differentiation positive regulation of male mating behavior negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process
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