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Invitrogen

HSP90 Monoclonal Antibody (H9010), APC

View all (27) HSP90 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

MA5-45102

Applications Tested Dilution Publications

Western Blot (WB)

 1:2,500 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:100 -

Immunohistochemistry (PFA fixed) (IHC (PFA))

 1:10,000 -

Immunocytochemistry (ICC/IF)

 Assay-dependent -

ELISA (ELISA)

 Assay-dependent -

Immunoprecipitation (IP)

 Assay-dependent -
Product Specifications

Species Reactivity

 Dog, Chicken, Fish, Hamster, Human, Mouse, Rabbit, Rat, Shark

Host/Isotype

 Mouse / IgG2a

Class

 Monoclonal

Type

 Antibody

Clone

 H9010

Immunogen

Recombinant human HSP90beta

Conjugate

 APC

Excitation/Emission Max

 651/660 nm View spectra spectra

Form

 Liquid

Concentration

 1 mg/mL

Purification

 Protein G

Storage buffer

 PBS/MES, pH 7.2, with 0.0213% EDTA

Contains

 no preservative

Storage conditions

 4° C

Target Information

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock cognate protein HSP 90-beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 beta; heat shock protein 90 kDa; heat shock protein 90 kDa alpha class B member 1; heat shock protein 90A; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP84; HSP86; hsp90 beta; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen

Gene Aliases: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; I79_004665; LAP-2; LAP2

UniProt ID: (Chicken) P11501, (Human) P07900, (Rabbit) P30947, (Human) P08238, (Chicken) Q04619, (Mouse) P07901, (Chinese hamster) P46633, (Rat) P82995, (Mouse) P11499, (Rat) P34058

Entrez Gene ID: (Chicken) 423463, (Dog) 480438, (Human) 3320, (Rabbit) 100338694, (Rabbit) 100358690, (Human) 3326, (Dog) 474919, (Chicken) 396188, (Mouse) 15519, (Chinese hamster) 100689397, (Rat) 299331, (Mouse) 15516, (Rat) 301252

Molecular Function: Hsp90 family chaperone

Function(s)
protein folding positive regulation of cell proliferation response to heat response to cold response to organonitrogen compound response to organic cyclic compound response to progesterone cellular response to heat positive regulation of nitric oxide biosynthetic process response to antibiotic regulation of catalytic activity protein stabilization positive regulation of cell cycle G2/M phase transition G2/M transition of mitotic cell cycle neuron migration skeletal muscle contraction mitochondrial transport receptor-mediated endocytosis response to unfolded protein signal transduction response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process peptidyl-tyrosine phosphorylation regulation of protein ubiquitination positive regulation of protein import into nucleus, translocation Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway protein refolding regulation of protein complex assembly protein unfolding response to estrogen protein import into mitochondrial outer membrane positive regulation of cell size vascular endothelial growth factor receptor signaling pathway regulation of nitric-oxide synthase activity chaperone-mediated protein complex assembly positive regulation of cardiac muscle contraction chaperone-mediated autophagy regulation of cellular response to heat placenta development virion attachment to host cell positive regulation of protein binding negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of phosphoprotein phosphatase activity negative regulation of neuron apoptotic process regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to interleukin-4 cellular response to organic cyclic compound positive regulation of protein serine/threonine kinase activity fibril organization cell-cell adhesion positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell cycle arrest negative regulation of transforming growth factor beta activation nitric oxide biosynthetic process response to stress positive regulation of cytotoxic T cell differentiation
Process(es)
ATP binding protein C-terminus binding ATPase activity nitric-oxide synthase regulator activity estrogen receptor binding TPR domain binding heat shock protein binding progesterone receptor binding identical protein binding virion binding unfolded protein binding chaperone binding Hsp90 protein binding disordered domain specific binding nucleotide binding UTP binding CTP binding mRNA binding protein tyrosine kinase activity protein binding GTP binding sulfonylurea receptor binding protein kinase binding protein phosphatase binding MHC class II protein complex binding dATP binding protein homodimerization activity histone deacetylase binding ion channel binding poly(A) RNA binding GTPase binding Rho GDP-dissociation inhibitor binding double-stranded RNA binding protein kinase regulator activity kinase binding cadherin binding involved in cell-cell adhesion protein dimerization activity
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