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Product Details
TA500948
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3G8
Immunogen
Full length human recombinant protein of human IFIT1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GARG-16; glucocorticoid-attenuated response gene 16 product; Glucocorticoid-attenuated response gene 16 protein; IFI-56K; IFIT-1; interferon, alpha-inducible protein (MW 56kD); Interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1; interferon-induced protein with tetratricopeptide repeats 1-like protein; interferon-inducible mRNA 561
Gene Aliases: C56; G10P1; Garg16; IFI-56; IFI-56K; IFI56; IFIT-1; IFIT1; IFNAI1; ISG56; P56; RNM561
UniProt ID: (Human) P09914, (Mouse) Q64282
Entrez Gene ID: (Human) 3434, (Mouse) 15957, (Rat) 56824
response to virus
intracellular transport of viral protein in host cell
negative regulation of protein binding
positive regulation of viral genome replication
negative regulation of viral genome replication
negative regulation of defense response to virus by host
negative regulation of helicase activity
defense response to virus
type I interferon signaling pathway
cellular response to type I interferon
cellular response to exogenous dsRNA
immune system process
cellular response to interferon-alpha
cellular response to interferon-beta
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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