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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||full length protein IL-33|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.25 µg/0.5X10^6 cells|
|Western Blot (WB)||1-10 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
IL-33 is a 270 amino acid highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. It is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. It is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer"e;s patches and mesenteric lymph nodes and is almost undetectable in placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
C9orf26; DVS27; DVS27-related protein; IL-1F11; IL1F11; interleukin-1 family member 11; interleukin-33; NF-HEV; NFEHEV; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; RP11-575C20.2
C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV; NFHEV