MA5-15516 targets ISL1 in IF and WB applications and shows reactivity with Human samples.
The MA5-15516 immunogen is purified recombinant fragment of human ISL1 expressed in E. Coli.
MA5-15516 detects ISL1 which has a predicted molecular weight of approximately 39kDa.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
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Protein Aliases: Insulin gene enhancer protein ISL-1; Isl-1; ISL1; ISL1 transcription factor, LIM/homeodomain; Islet-1; ISLET1
Gene Aliases: Isl-1; ISL1; ISLET1
UniProt ID: (Human) P61371
Entrez Gene ID: (Human) 3670