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Product Details
H00000182-M08
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1-5 µg/mL | - |
ELISA (ELISA) |
10 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b, kappa |
Class |
Monoclonal |
Type |
Antibody |
Clone |
3C10 |
Immunogen |
JAG1 (NP_000205, 905 a.a. approximately 1014 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
See Label |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Sequence of this protein is as follows: HKGHSECPSG QSCIPILDDQ CFVHPCTGVG ECRSSSLQPV KTKCTSDSYY QDNCANITFT FNKEMMSPGL TTEHICSELR NLNILKNVSA EYSIYIACEP SPSANNEIHV
Target Information
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1
Gene Aliases: AGS; AHD; AWS; CD339; HJ1; JAG1; JAGL1
UniProt ID: (Human) P78504
Entrez Gene ID: (Human) 182
angiogenesis
cell fate determination
blood vessel remodeling
morphogenesis of an epithelial sheet
T cell mediated immunity
pulmonary valve morphogenesis
cardiac right ventricle morphogenesis
Notch signaling pathway
Notch receptor processing
nervous system development
hemopoiesis
keratinocyte differentiation
regulation of cell migration
response to muramyl dipeptide
aorta morphogenesis
regulation of cell proliferation
auditory receptor cell differentiation
myoblast differentiation
endothelial cell differentiation
negative regulation of fat cell differentiation
positive regulation of myeloid cell differentiation
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
cardiac septum morphogenesis
ciliary body morphogenesis
pulmonary artery morphogenesis
cardiac neural crest cell development involved in outflow tract morphogenesis
Notch signaling involved in heart development
endocardial cushion cell development
nephron development
glomerular visceral epithelial cell development
distal tubule development
loop of Henle development
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
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