This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.
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Protein Aliases: A-type potassium channel modulatory protein 1; KChIP1; KCHIP2; Kv channel interacting protein 1; Kv channel-interacting protein 1; potassium channel interacting protein 1; Potassium channel-interacting protein 1; Vesicle APC-binding protein
Gene Aliases: KCHIP1; KCNIP1; VABP
UniProt ID: (Human) Q9NZI2
Entrez Gene ID: (Human) 30820