This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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MA5-15672 targets KLF4 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.
The MA5-15672 immunogen is purified recombinant fragment of human KLF4 (Amino Acid: 2-470) expressed in E. Coli.
MA5-15672 detects KLF4 which has a predicted molecular weight of approximately 55kDa.
Kruppel like factor 4 (KLF4) protein is encoded by the KLF4 gene located on chromosome 9 in humans. It is also known as gut-enriched Kruppel-like factor (GKLF) or epithelial zinc-finger protein (EZF) and belongs to a family of conserved Kruppel-like factor family of DNA binding zinc finger transcription factors. KLF4 exerts its functional relevance across varied cellular pathways. As one of the four Yamanaka factors, it plays a key role in reprogramming differentiated cells into pluripotent stem cells. Most studies have focused on its specific role in endothelial cell signaling, adipogenesis, differentiation, embryogenesis and cell cycle control. Localization plays an important role in the biological significance of this protein wherein nuclear localization is associated with its function as an oncogene and cytosolic localization with tumor suppression specific effect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 4; Kruppel-like factor 4 (gut); RP11-150J11.1
Gene Aliases: EZF; GKLF; KLF4
UniProt ID: (Human) O43474
Entrez Gene ID: (Human) 9314
Molecular Function: C2H2 zinc finger transcription factor