A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.
Baakdhah TW,Coles B,van der Kooy D
12-5698-82 was used in Flow Cytometry to conclude that HP and LP spheres contain late RPE progenitors which are not affected by proliferative signals.
Fri Jun 25 00:00:00 EDT 2021
Pax6 Lengthens G1 Phase and Decreases Oscillating Cdk6 Levels in Murine Embryonic Cortical Progenitors.
Frontiers in cellular neuroscience
Mi D,Manuel M,Huang YT,Mason JO,Price DJ
12-5698 was used in Flow cytometry/Cell sorting to investigate whether, in addition to Cdk6, other Pax6-regulated cell cycle genes are likely to be primary mediators of Pax6's actions on cortical progenitor cell cycles.
Thu Mar 04 00:00:00 EST 2021
Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory.
Soon MSF,Lee HJ,Engel JA,Straube J,Thomas BS,Pernold CPS,Clarke LS,Laohamonthonkul P,Haldar RN,Williams CG,Lansink LIM,Moreira ML,Bramhall M,Koufariotis LT,Wood S,Chen X,James KR,Lönnberg T,Lane SW,Belz GT,Engwerda CR,Khoury DS,Davenport MP,Svensson V,Teichmann SA,Haque A
12-5698 was used in Flow cytometry/Cell sorting to apply single-cell RNA sequencing and computational modelling to track memory development during Plasmodium infection and treatment.
Tue Dec 01 00:00:00 EST 2020
Novel cytokine-antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma.
Journal for immunotherapy of cancer
Chu Y,Nayyar G,Kham Su N,Rosenblum JM,Soon-Shiong P,Lee J,Safrit JT,Barth M,Lee D,Cairo MS
12-5698 was used in Flow cytometry/Cell sorting to provide the rationale for the development of a clinical trial of N-820 alone or in combination with endogenous or ex vivo expanded NK cells in patients with CD20+ B-NHL failing prior rituximab containing chemoimmunotherapy regimens.
Thu Oct 01 00:00:00 EDT 2020
Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice.
Journal of the American Heart Association
Du LJ,Sun JY,Zhang WC,Wang YL,Zhu H,Liu T,Gao MZ,Zheng C,Zhang YY,Liu Y,Liu Y,Shao S,Zhang XQ,Leng Q,Auwerx J,Duan SZ
12-5698 was used in Flow cytometry/Cell sorting to demonstrate that NCOR1 is a critical regulator of macrophage inflammation and proliferation and that deficiency of NCOR1 in macrophages attenuates MI and neointimal hyperplasia.
Tue Aug 04 00:00:00 EDT 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
12-5698 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-5698 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
Tissue-Resident Macrophages Promote Renal Cystic Disease.
Journal of the American Society of Nephrology : JASN
Zimmerman KA,Song CJ,Li Z,Lever JM,Crossman DK,Rains A,Aloria EJ,Gonzalez NM,Bassler JR,Zhou J,Crowley MR,Revell DZ,Yan Z,Shan D,Benveniste EN,George JF,Mrug M,Yoder BK
12-5698 was used in Immunohistochemistry (PFA fixed) to investigate the role of resident macrophages during rapid cyst progression in mice.
Tue Oct 01 00:00:00 EDT 2019
Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome.
Yang C,Siebert JR,Burns R,Gerbec ZJ,Bonacci B,Rymaszewski A,Rau M,Riese MJ,Rao S,Carlson KS,Routes JM,Verbsky JW,Thakar MS,Malarkannan S
12-5698-82 was used in Flow Cytometry to identify distinct NK populations in human bone marrow and blood, including one population expressing higher levels of immediate early genes indicative of a homeostatic activation.
Mon Sep 02 00:00:00 EDT 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
12-5698-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro.
Cell stem cell
Luchsinger LL,Strikoudis A,Danzl NM,Bush EC,Finlayson MO,Satwani P,Sykes M,Yazawa M,Snoeck HW
12-5698 was used in Flow cytometry/Cell sorting to reveal a physiological feature of HSCs that can be harnessed to improve their maintenance in vitro.
Thu Aug 01 00:00:00 EDT 2019
Single-cell analysis reveals T cell infiltration in old neurogenic niches.
Dulken BW,Buckley MT,Navarro Negredo P,Saligrama N,Cayrol R,Leeman DS,George BM,Boutet SC,Hebestreit K,Pluvinage JV,Wyss-Coray T,Weissman IL,Vogel H,Davis MM,Brunet A
12-5698 was used in Flow cytometry/Cell sorting to reveal an interaction between T cells and neural stem cells in old brains, opening potential avenues through which to counteract age-related decline in brain function.
Mon Jul 01 00:00:00 EDT 2019
Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.
Frontiers in immunology
Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K
12-5698 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.
Tue Jun 25 00:00:00 EDT 2019
Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges.
The Journal of experimental medicine
Silva HM,Báfica A,Rodrigues-Luiz GF,Chi J,Santos PDA,Reis BS,Hoytema van Konijnenburg DP,Crane A,Arifa RDN,Martin P,Mendes DAGB,Mansur DS,Torres VJ,Cadwell K,Cohen P,Mucida D,Lafaille JJ
12-5698 was used in Flow cytometry/Cell sorting to investigate if tissue-resident macrophages from healthy epididymal white adipose tissue (eWAT), not only surround adipocytes but also associate tightly with blood vessels, being among the most endocytic cells in the body for blood-borne macromolecules.
Mon Apr 01 00:00:00 EDT 2019
PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells.
Tan DQ,Li Y,Yang C,Li J,Tan SH,Chin DWL,Nakamura-Ishizu A,Yang H,Suda T
12-5698 was used in Immunocytochemistry-immunoflourescence to establish the importance of cell-intrinsic protein arginine methyltransferase 5 activity in hematopoietic stem cells.
Tue Feb 26 00:00:00 EST 2019
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.
Proietti M,Perruzza L,Scribano D,Pellegrini G,D'Antuono R,Strati F,Raffaelli M,Gonzalez SF,Thelen M,Hardt WD,Slack E,Nicoletti M,Grassi F
12-5698-82 was used in Flow Cytometry to show that modulation of eATP in the small intestine can affect high-affinity IgA response against gut colonizing bacteria.
Wed Jan 16 00:00:00 EST 2019
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Cell stem cell
Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J
12-5698-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.
Thu Mar 01 00:00:00 EST 2018
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
12-5698 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 EST 2018
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
12-5698 was used in Flow cytometry/Cell sorting to study the regulation of cell cycle entry in quiescent T cells by store-operated Ca2+ entry and calcineurin.
Tue Oct 17 00:00:00 EDT 2017
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
12-5698-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Wells AC,Daniels KA,Angelou CC,Fagerberg E,Burnside AS,Markstein M,Alfandari D,Welsh RM,Pobezinskaya EL,Pobezinsky LA
12-5698 was used in Flow cytometry/Cell sorting to identify a let-7-mediated mechanism that acts as a molecular brake controlling the magnitude of CD8 T-cell responses.
Mon Jul 24 00:00:00 EDT 2017
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection.
Yi P,Liang Y,Yuan DMK,Jie Z,Kwota Z,Chen Y,Cong Y,Fan X,Sun J
12-5698 was used in Flow cytometry/Cell sorting to reveal a significant effect of the IL-23/PI3K/mTORC1 axis on regulating IL-22 production and also identify a novel role of IL-22 in controlling antiviral T cell responses in the non-lymphoid and lymphoid organs during acute and persistent viral infections.
Tue Jun 20 00:00:00 EDT 2017
Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain.
Varol D,Mildner A,Blank T,Shemer A,Barashi N,Yona S,David E,Boura-Halfon S,Segal-Hayoun Y,Chappell-Maor L,Keren-Shaul H,Leshkowitz D,Hornstein E,Fuhrmann M,Amit I,Maggio N,Prinz M,Jung S
12-5698 was used in Flow cytometry/Cell sorting to examine the impact of post-transcriptional control mediated by microRNAs on microglial performance during development and adulthood.
Tue Jun 20 00:00:00 EDT 2017
Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions.
Bernitz JM,Kim HS,MacArthur B,Sieburg H,Moore K
12-5698 was used in Flow cytometry/Cell sorting to suggest that HSCs accumulate discrete memory stages over their divisional history and identify cellular memory in HSC aging.
Thu Nov 17 00:00:00 EST 2016
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
12-5698-82 was used in Immunohistochemistry to demonstrate a novel mutualistic host-protozoan interaction that increases mucosal host defenses at the cost of an increased risk of inflammatory disease.
Thu Oct 06 00:00:00 EDT 2016
Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.
Ramo K,Sugamura K,Craige S,Keaney JF,Davis RJ
12-5698 was used in Immunofluorescence to investigate the role of the MLK-JNK signalling pathway in regulating protective mechanisms against ischemia in arterial occlusive disease.
Tue Aug 09 00:00:00 EDT 2016
Programmed death 1 regulates memory phenotype CD4 T cell accumulation, inhibits expansion of the effector memory phenotype subset and modulates production of effector cytokines.
Charlton JJ,Tsoukatou D,Mamalaki C,Chatzidakis I
12-5698 was used in Flow cytometry/Cell sorting to demonstrate that PD-1 has an important role in determining the composition and functional aspects of the memory phenotype CD4 T cell pool.
Wed Apr 13 00:00:00 EDT 2016
Interaction of natural killer cells with neutrophils exerts a significant antitumor immunity in hematopoietic stem cell transplantation recipients.
Ueda R,Narumi K,Hashimoto H,Miyakawa R,Okusaka T,Aoki K
12-5698 was used in Flow cytometry/Cell sorting to study a novel aspect of antitumor immunity induced by HSCT and may contribute to the development of an effective therapeutic strategy for cancer using HSCT.
Fri Jan 01 00:00:00 EST 2016
Inflammation rapidly reorganizes mouse bone marrow B cells and their environment in conjunction with early IgM responses.
Moreau JM,Berger A,Nelles ME,Mielnik M,Furlonger C,Cen SY,Besla R,Robbins CS,Paige CJ
12-5698 was used in Flow cytometry/Cell sorting to study the rapidity with which peripheral inflammation modifies the bone marrow compartment, and demonstrate that such modifications regulate acute IgM production within this organ.
Thu Sep 03 00:00:00 EDT 2015
Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.
Liu J,Copland DA,Horie S,Wu WK,Chen M,Xu Y,Paul Morgan B,Mack M,Xu H,Nicholson LB,Dick AD
Thu Jan 15 00:00:00 EST 2015
Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.
Genes & development
Li Y,Esain V,Teng L,Xu J,Kwan W,Frost IM,Yzaguirre AD,Cai X,Cortes M,Maijenburg MW,Tober J,Dzierzak E,Orkin SH,Tan K,North TE,Speck NA
12-5698 was used in Flow cytometry/Cell sorting to show that sterile tonic inflammatory signalling regulates embryonic haematopoietic stem and progenitor cell formation.
Mon Dec 01 00:00:00 EST 2014
Beneficial role of rapamycin in experimental autoimmune myositis.
Prevel N,Allenbach Y,Klatzmann D,Salomon B,Benveniste O
12-5698 was used in Flow cytometry/Cell sorting to investigate the effect of rapamycin on different immune cell sub-populations in experimental autoimmune myositis.
Fri Jul 25 00:00:00 EDT 2014
Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice.
Montufar-Solis D,Vigneswaran N,Nakra N,Schaefer JS,Klein JR
12-5698 was used in Flow cytometry/Cell sorting to investigate the intestinal immunopathology caused by insufficient Roquin, showing that hematopoietic, not systematic, impairment of Roquin expression accounts for pathology.
Mon May 12 00:00:00 EDT 2014
Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer.
Aida K,Miyakawa R,Suzuki K,Narumi K,Udagawa T,Yamamoto Y,Chikaraishi T,Yoshida T,Aoki K
12-5698 was used in Flow cytometry/Cell sorting to examine whether the suppression of regulatory T cells within tumours can enhance an antitumour immunity induced by an intratumoural interferon-α gene transfer.
Sat Feb 01 00:00:00 EST 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
12-5698 was used in in vivo experiments to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Arteriolar niches maintain haematopoietic stem cell quiescence.
Kunisaki Y,Bruns I,Scheiermann C,Ahmed J,Pinho S,Zhang D,Mizoguchi T,Wei Q,Lucas D,Ito K,Mar JC,Bergman A,Frenette PS
12-5698 was used in Immunofluorescence on wholemounted tissues to investigate the spatial localisation of quiescent haematopoietic stem cells in bone marrow, showing that arteriolar niches maintain quiescence.
Thu Oct 31 00:00:00 EDT 2013
Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens.
Journal of immunology (Baltimore, Md. : 1950)
Yammani RD,Haas KM
Mon Apr 01 00:00:00 EDT 2013
IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.
Pang IK,Ichinohe T,Iwasaki A
Fri Mar 01 00:00:00 EST 2013
Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice.
Journal of leukocyte biology
Ma C,Kapanadze T,Gamrekelashvili J,Manns MP,Korangy F,Greten TF
12-5698 was used in Flow cytometry/Cell sorting to examine the effect of systemic RB6-8C5 treatment on hepatic myeloid-derived suppressor cells in tumour-bearing mice.
Sat Dec 01 00:00:00 EST 2012