Invitrogen

Ki-67 Monoclonal Antibody (SolA15), eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

87 Published Figures

327 References

View all (195) Ki-67 antibodies

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Datasheet

Protocols

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Tech Support

Ki-67 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 97

Ki-67 Antibody (14-5698-82) in IHC (P)

Immunohistochemical analysis of Ki-67 was performed using formalin-fixed paraffin-embedded human colon adenocarcinoma tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15... View More

Product Image Gallery

Ki-67 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence analysis of Ki67 was performed using 70% confluent log phase HeLa cells serum starved for 36 Hrs followed by serum release for 6 Hrs. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with Ki-67 Monoclonal Antibody (SolA15), eBioscience™ (Product # 14-5698-82) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rat IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488 (Product # A1-1006, 1:2000 dilution) for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b: Blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing nuclear localization. Panel e represents serum starved cells with reduced signal. Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.

Ki-67 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow) — Figure 5. mTORC1 inhibition fails to drive activated SSC accumulation and early progenitor depletion in the absence of intercellular bridges (A and B) WM-IIF of PLZF (green, spermatogonia), RARgamma (red, late progenitors), SOX3 (white, early/late progenitors) or KIT (white, differentiating spermatogonia), and Ki67 (blue, proliferation) in seminiferous tubules from P36 Tex14 -/- mice. Arrowhead, quiescent SSCs (PLZF+/SOX3-/RARgamma/Ki67-) or early progenitors (PLZF+/KIT-/RARgamma-/Ki67-); arrow, activated SSCs (PLZF+/SOX3-/RARgamma-/Ki67+) or early progenitors (PLZF+/KIT-/RARgamma-/Ki67+); circle, early progenitors (PLZF+/SOX3+/RARgamma-/Ki67+); asterisk, late progenitors (PLZF+/SOX3+ or KIT-/RARgamma+/Ki67-). Scale bar, 20 mum. (C) Proportion of SSCs (KIT-/PLZF low /SOX3 low /RARgamma low ), early progenitors (KIT-/PLZF low /SOX3 high /RARgamma low ), and late progenitors (KIT-/PLZF high /SOX3 high /RARgamma high ) in seminiferous tubule cells from control (n = 3) and rapamycin-treated (n = 3) Tex14 -/- mice at P36 (see controls in Figure S3J ). Data are mean +- SEM. (D) Ki67 staining intensity in SSCs (KIT-/PLZF low /SOX3 low /RARgamma low ), early progenitors (KIT-/PLZF low /SOX3 high /RARgamma low ), and late progenitors (KIT-/PLZF high /SOX3 high /RARgamma high ) in seminiferous tubule cells from Tex14 +/- , Tex14 -/- , and rapamycin-treated Tex14 -/- mice (n = 3 each) at P36 (see controls in Figure S3J ). Data are mean +- SEM. Two-tailed Student''s t test (***p < 0.001)

Ki-67 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC) — Figure 4 SARS-CoV-2 Infection Induces Loss of Surfactants and AT2 Death (A) Schematic for SARS-CoV-2-GFP infection in human alveolospheres. Alveolospheres were cultured in SFFF medium, infected with SARS-CoV-2 virus, and collected for histological analysis. (B) Quantification of the percentage of SARS-CoV-2-infected alveolospheres. (C) Immunostaining for GFP (green), SFTPC (red), and SARS (gray) (top panel) and GFP (green) and SFTPB (red) (bottom panel) in control, ""low,"" and ""high"" SARS-CoV-2-GFP-infected human lung alveolospheres at 72 h post-infection. Scale bar: 50 mum. (D) Quantification of low-infected (1-10 SARS-CoV-2 + cells) and high-infected (10 or more SARS-CoV-2 + cells) alveolospheres. (E) Quantification of SFTPC + cells in uninfected control and SARS - and SARS + cells in virus-infected alveolospheres. (F) Immunostaining for GFP (green) in combination with the apoptotic marker active caspase 3 (red) and proliferation marker Ki67 (gray) in control and SARS-CoV-2-GFP-infected alveolospheres. Scale bar: 30 mum. (G and H) Quantification of active caspase-3 (CASP3) + (G) and Ki67 + (H) cells in uninfected control (gray), SARS-CoV-2 - cells (blue), and SARS-CoV-2 + cells in infected alveolospheres. The white box in the merged image indicates the region of single-channel images. DAPI stains nuclei (blue). All quantification data are presented as mean +- SEM.

Ki-67 Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P)) — Figure 1 (A) Scheme of experiments. (B) Representative image (at 10X, transmitted light microscopy) of GBM143 xenograft line cultured for 3 weeks in vitro in media indicated; cells were collected and orthotopically implanted into cranially irradiated mice 24 hrs post-irradiation (IR). (C) Representative Immunofluorescence (IF) images (at 4X, tiling) for hLamin A+C staining from 0 Gy and 20 Gy-IR mice coronal sections to assess tumor growth and invasion. (D) Top: Representative images (at 20X) show IF staining at tumor; and the dot-plot of single cell count for hLamin A+C and Ki67 staining. Bottom: Representative images (at 20X) show IF staining at center of corpus callosum, and dot-plot of single cell count for hLamin A+C. IH, ipsilateral hemisphere; CH, contralateral hemisphere; IR, irradiation. Statistical significance is represented as * p < 0.05.

Ki-67 Antibody in Western Blot, Immunocytochemistry (WB, ICC/IF) — Figure 4. Cell proliferation without Ki-67. ( A ) Schematic representation of strategy for TALEN-mediated generation of Mki67 null allele. ( B ) qRT-PCR analysis of Ki-67 mRNA levels in NIH-3T3 WT clone W4 and Ki-67-negative 60, 65, 99 clones. ( C ) Top: Western blot of Ki-67 and Cyclin A in NIH-3T3 WT clone W4 and Ki-67-negative mutant clones 60, 65, 99; LC, loading control; below, Ki-67 immunofluorescence; bar, 10 um. ( D ) Left, growth curves of WT and Ki-67 null cell lines 60, 65 and 99; right, cell cycle distribution analysed by flow cytometry. ( E ) Cell cycle length of WT clone W4 and Ki-67 null clones 60 and 65 as determined by time-lapse videomicroscopy. ( F ) Cells of clone 65 show altered chromosomal periphery in mitosis. The Ki-67 staining is deliberately overexposed to demonstrate absence of detectable Ki-67 in clone 65, even in metaphase. Bar, 5 um. DOI: http://dx.doi.org/ Figure 4--figure supplement 1. Generation of NIH-3T3 cells lacking Ki-67. Top, schematic representation of the wild type (WT), knock-out or eGFP knock-in Mki67 locus and the predicted insertion of tandem repeats of the eGFP insert upstream of Mki67 locus. Bottom, Southern-blot of two NIH-3T3 WT clones (WT, W4) and six NIH-3T3 Ki-67 mutant clones (60,63,65,82,99). Clones were digested with PstI or SphI and probed with 5' or 3' probe, respectively. DOI: http://dx.doi.org/

Ki-67 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P)) — Figure 4. Increased cell cycle reentry of airway basal cells in CCR2 -/- airways following resolution of influenza virus infection. Representative immunostaining of murine tracheal epithelium of C57BL/6 and CCR2 -/- mice, for Ki67 (green), Krt5 (red), and nuclei (blue) at 14 d after H1N1/PR8 influenza A infection. Two representative images are shown for each mouse strain at 14 d after influenza virus infection. All images were obtained using 20x objective lens with scale bars, 50 um.

Ki-67 Antibody in Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed) (IHC (P), IHC (PFA)) — Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (Paraffin) and Immunohistochemistry (PFA fixed)

Ki-67 Antibody in Immunohistochemistry (Frozen) (IHC (F)) — Figure 5 iCOUNT signal in adult mouse tissues (A) Overview of an adult iCOUNT mouse with expression of the tagged H3.1 in diverse tissues as indicated. (B) FACS analyses of cells with distinct red/green histone ratios in diverse tissues as indicated. Left panel shows controls, and right panel shows cells expressing newly synthesized (green) histones after inducible Cre-based recombination. (C) Conditional recombination in adult NSPCs identifies iCOUNT-targeted cells in the adult brain. Left panels show overview, and boxed areas are shown in higher magnification (right panels). (D) 4i-based phenotyping of Cre-targeted cells in the adult hippocampus using a panel of protein markers as indicated reveals radial glia-like NSPCs (R), non-radial glia-like NSPCs (NR), actively dividing NR (KI67+), and newborn neurons. (E) Quantification of green/total fluorescence and predicted division numbers of cells in the adult hippocampus 2 weeks after Cre-based recombination (mean +- SD). (F) Number of previous cell divisions based on iCOUNT and chronic intravital imaging. Note the comparable distribution among R, NR, and newborn neurons. Nuclei were counterstained with DAPI (blue). n >= 10 cells derived from >= 3 mice (E). **** p < 0.0001, ns, not significant. Images were stitched. Scale bars represent 100 mum in (A) and (C) and 20 mum in (C, right panels) and (D). See also Figure S5 .

Ki-67 Antibody in Immunohistochemistry, Immunohistochemistry (Frozen) (IHC, IHC (F)) — Fig. 4 Elevated Tet1 is essential for MB progression. a , b Kaplan-Meier curves show the significant increase in survival from SmoA1 +/+ mice crossed with hemizygous deletion of Tet1 ( a p < 0.0001; log-rank test), but not crossed with hemizygous deletion of Tet2 ( b p = 0.5830; log-rank test). c , d 5hmC dot blot analysis shows significant increase in 5hmC levels in tumors from SmoA1 +/+ ; Tet1 +/- mice ( n = 5; 3 representative samples shown) compared to tumors from SmoA1 +/+ ( n = 5; 3 representative samples shown) despite similar ages of tumor-associated symptoms shown in box plot below dot blot ( n = 5 per group). e Tet1 protein expression is significantly higher in SmoA1-MBs ( n = 7) compared to corresponding NCs ( n = 4) ( p < 0.05). f Pearson correlation between Tet1 expression and age-of-onset (Pearson R 2 = 0.5059, * p = 0.0366). g H&E staining (left) and ratio per phenotype (right) of 12-week-old SmoA1 +/+ mice in the presence of either wild-type or hemizygous deletion of Tet1 ( p < 0.0001; Welch's t -test). h Fluorescence microscopy of normal cerebellum and MB with Ki67 (red) and Tet1 (green) in 12-week-old SmoA1 +/+ mice showing Tet1 expression is significantly higher in Ki67-positive cells (blue: DAPI, **** p < 0.001)

Ki-67 Antibody in Immunohistochemistry (IHC) — Treatment with Q-Peptide Hydrogel leads to faster resolution of proliferating keratinocytes at the margin of the wound. Representative sections of immunohistochemical analysis for Ki67 at ( A ) d14 and ( B ) d28. Dashed line indicates basal epithelial layer. Arrows show Ki67 positive nuclei. (scale bar = 100 um). ( C ) Quantification of total number of Ki67+ cells in one high powered field of view at the epithelial edge (averaged from 4 separate tissue sections spanning the center of the wound) revealed significantly fewer proliferating basal epithelial cells on Day 14 following treatment with Q-Peptide Hydrogel compared with no treatment control. Data are presented as mean +- SD. * p < 0.05, N = 3.

Ki-67 Antibody in Immunohistochemistry, Immunohistochemistry (PFA fixed) (IHC, IHC (PFA)) — Fig. 3 Genetic lineage tracing shows fewer adult born neurons from Tcf4 -deleted nestin -expressing progenitors. ( A ) Schematic for genetic lineage tracing experimental regime. ( B and C ) Representative images (B) quantitation (C) of genetic reporter-based tracing of progenitors 30 days after deletion for DCX expression. ( D ) Genetic reporter-based tracing of progenitors 60 days after deletion for Calbindin expression. ( E and F ) Quantitation of genetically traced Calbindin+ve and Prox1+ve mature neurons. ( G and H ) Representative images (G) quantitation (H) of genetic lineage tracing for Ki67+ve progeny at day 7 after deletion. n = 3 animals per genotype, each dot represents a section from a brain, and error bar represents SD. (unpaired t test, * P < 0.01, ** P < 0.001, and *** P < 0.0003). Scale bars, 50 mum.

Ki-67 Antibody — Immunofluorescence analysis of Ki67 was performed using 70% confluent log phase HeLa cells serum starved for 36 Hrs followed by serum release for 6 Hrs. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with Ki-67 Monoclonal Antibody (SolA15), eBioscience™ (Product # 14-5698-82) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175), (1:2,000 dilution) for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b: Blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415 , 1:300). Panel d represents the merged image showing Cytoplasmic localization. Panel e represents HeLa cells serum starved for 36 Hrs with reduced signal. Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification. {TM}

Product Details

14-5698-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 148 publications 148 publications

Immunohistochemistry (Paraffin) (IHC (P))

2.5-5 µg/mL

View 14 publications 14 publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

View 4 publications 4 publications

Immunohistochemistry (Frozen) (IHC (F))

5 µg/mL

View 10 publications 10 publications

Immunocytochemistry (ICC/IF)

1:00

View 66 publications 66 publications

Flow Cytometry (Flow)

View 85 publications 85 publications

Functional Assay (FN)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Dog, Cynomolgus monkey, Human, Mouse, Non-human primate, Rat

Published species

Dog, Human, Mouse, Mustelid, Pig, Rat

Host/Isotype

Rat / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

SolA15

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C

RRID

AB_10854564

Product Specific Information

Description: The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein. Ki-67 is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0). Ki-67 is detected within the nucleus during interphase but redistributes to the chromosomes during mitosis. Ki-67 is used as a marker for determining the growth fraction of a given population of cells. In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. Ki-67 has been shown to interact with the DNA-bound protein chromobox protein homolog 3 (CBX3) (heterochromatin).

The SolA15 antibody also recognizes human, non-human primate and canine Ki-67.

Applications Reported: This SolA15 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded (FFPE) tissue sections and frozen (paraformaldehyde fixed) sections and immunocytochemistry (ICC).

Applications Tested: This SolA15 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded mouse skin with high or low pH antigen retrieval and immunocytochemistry on fixed and permeabilized C2C12 cells at less than or equal to 5 µg/mL. It is recommended that this antibody be carefully titrated for optimal performance in the assay of interest.

Purity: Greater than 90%, as determined by SDS-PAGE.

Aggregation: Less than 10%, as determined by HPLC.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Poly-L-ornithine blocks the inhibitory effects of fibronectin on oligodendrocyte differentiation and promotes myelin repair.

Neural regeneration research

Xiong YJ,Soomro SH,Huang ZH,Yu PP,Ping J,Fu H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Sat Apr 01 00:00:00 EDT 2023

Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells.

Science advances

Petrelli F,Scandella V,Montessuit S,Zamboni N,Martinou JC,Knobloch M

14-5698-82 was used in Immunohistochemistry to highlight the importance of metabolism for NSPC regulation and identify an important pathway through which mitochondrial pyruvate import controls NSPC quiescence and activation.

Wed Mar 01 00:00:00 EST 2023

Voluntary running exercise modifies astrocytic population and features in the peri-infarct cortex.

IBRO neuroscience reports

Yamaguchi N,Sawano T,Nakatani J,Nakano-Doi A,Nakagomi T,Matsuyama T,Tanaka H

14-5698-82 was used in Immunohistochemistry to suggest that exercise modifies the composition of astrocytic population and their phenotype.

Thu Jun 01 00:00:00 EDT 2023

Dynamic states of cervical epithelia during pregnancy and epithelial barrier disruption.

iScience

Cooley A,Madhukaran S,Stroebele E,Colon Caraballo M,Wang L,Akgul Y,Hon GC,Mahendroo M

14-5698-82 was used in Immunohistochemistry-immunofluorescence to find heterogeneous subpopulations of cervical epithelia displaying spatial and temporal specificity to maintain dynamic states of homeostasis in pregnancy and labour.

Fri Feb 17 00:00:00 EST 2023

Implantation and tracing of green fluorescent protein-expressing adipose-derived stem cells in peri-implant capsular fibrosis.

Stem cell research & therapy

Park BY,Wu D,Kwon KR,Kim MJ,Kim TG,Lee JH,Park DY,Kim IK

14-5698-82 was used in Immunohistochemistry to investigate the inhibitory role of ASCs on capsule formation by analyzing the histologic, cellular, and molecular changes in a mouse model of peri-implant fibrosis, and study the fate and distribution of ASCs in the peri-implant capsule.

Wed Feb 08 00:00:00 EST 2023

microRNA-17 is a tumor suppressor in oral squamous cell carcinoma and is repressed by LSD1.

Oral diseases

Wangzhou K,Fu W,Li M,Lu Z,Lai Z,Liu C,Tan Y,Hao C

14-5698-82 was used in Immunohistochemistry to investigate whether lysine-specific demethylase 1 (LSD1) affects the development of oral squamous cell carcinoma (OSCC) by sustaining the cancer stem cells from OSCC (OSCSCs).

Wed Mar 01 00:00:00 EST 2023

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

The Journal of clinical investigation

Liu Z,Yan M,Lei W,Jiang R,Dai W,Chen J,Wang C,Li L,Wu M,Nian X,Li D,Sun D,Lv X,Wang C,Xie C,Yao L,Wu C,Hu J,Xiao N,Mo W,Wang Z,Zhang L

14-5698-82 was used in Immunohistochemistry to demonstrate that coat protein complex II (COPII) component Sec13 is essential for oligodendrocyte differentiation and postnatal myelination.

Fri Apr 01 00:00:00 EDT 2022

HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53.

The Journal of investigative dermatology

Zhu X,Leboeuf M,Liu F,Grachtchouk M,Seykora JT,Morrisey EE,Dlugosz AA,Millar SE

14-5698-82 was used in Immunohistochemistry to find that homozygous epidermal codeletion of Hdac1 and Hdac2 in adult mouse epidermis causes reduced basal cell proliferation, apoptosis, inappropriate differentiation, and eventual loss of Hdac1/2-null keratinocytes.

Sat Jan 01 00:00:00 EST 2022

Human neural progenitors establish a diffusion barrier in the endoplasmic reticulum membrane during cell division.

Development (Cambridge, England)

Bin Imtiaz MK,Royall LN,Gonzalez-Bohorquez D,Jessberger S

14-5698-82 was used in Immunohistochemistry to investigate the existence of an endoplasmic reticulum diffusion barrier in human cells.

Sat Oct 15 00:00:00 EDT 2022

Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.

Diabetes, obesity & metabolism

Jiang Y,Chen A,Kline D,Liu Q,Ma J,Wang Y,Zhang T,Qian J,Nelson L,Prasadan K,Hu B,Gittes GK,Xiao X

14-5698-82 was used in Immunohistochemistry-immunofluorescence to show a regulatory loop between macrophages and beta cells through PlGF/EGF/ERK5 signalling cascades to regulate gestational beta cell growth.

Thu Sep 01 00:00:00 EDT 2022

Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury.

Neural regeneration research

Zhang XM,Zeng LN,Yang WY,Ding L,Chen KZ,Fu WJ,Zeng SQ,Liang YR,Chen GH,Wu HF

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Sat Jan 01 00:00:00 EST 2022

Application of an instructive hydrogel accelerates re-epithelialization of xenografted human skin wounds.

Scientific reports

Sparks HD,Mandla S,Vizely K,Rosin N,Radisic M,Biernaskie J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sat Aug 20 00:00:00 EDT 2022

Application of an instructive hydrogel accelerates re-epithelialization of xenografted human skin wounds.

Scientific reports

Sparks HD,Mandla S,Vizely K,Rosin N,Radisic M,Biernaskie J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sat Aug 20 00:00:00 EDT 2022

Deciphering the role of miR-187-3p/LRFN1 axis in modulating progression, aerobic glycolysis and immune microenvironment of clear cell renal cell carcinoma.

Discover. Oncology

Xu W,Liu W,Anwaier A,Tian X,Su J,Shi G,Wei S,Qu Y,Zhang H,Ye D

14-5698-82 was used in Immunohistochemistry to reveal the tumor-specific and immunological role of miR-187-3p/LRFN1 axis in the progression and reshaping of tumor immune microenvironment of ccRCC.

Thu Jul 07 00:00:00 EDT 2022

Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation.

Journal of neuroimmunology

Asano H,Hasegawa-Ishii S,Arae K,Obara A,Laumet G,Dantzer R,Shimada A

14-5698-82 was used in Immunohistochemistry-immunofluorescence to examine initial events that occur in the OB after bilateral intranasal administration of lipopolysaccharide, focusing on the olfactory nerve fibers and meninges.

Fri Jul 15 00:00:00 EDT 2022

Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats.

Stem cell research & therapy

Ye YC,Chang ZH,Wang P,Wang YW,Liang J,Chen C,Wang JJ,Sun HT,Wang Y,Li XH

14-5698-82 was used in Immunohistochemistry to investigate if exosomes secreted in response to infarction microenvironment could have further therapeutic effects.

Thu Jul 28 00:00:00 EDT 2022

A slow-cycling/quiescent cells subpopulation is involved in glioma invasiveness.

Nature communications

Antonica F,Santomaso L,Pernici D,Petrucci L,Aiello G,Cutarelli A,Conti L,Romanel A,Miele E,Tebaldi T,Tiberi L

14-5698-82 was used in Immunohistofluorescence to point to a subpopulation of quiescent cells as partially responsible of tumor invasiveness, one of the major causes of brain cancer morbidity.

Mon Aug 15 00:00:00 EDT 2022

Oligodendrogenesis is a key process for cognitive performance improvement induced by voluntary physical activity.

Glia

Eugenin von Bernhardi J,Dimou L

14-5698-82 was used in Immunohistochemistry-immunofluorescence to study the requirement of oligodendrogenesis for exercise induced-cognition enhancement.

Wed Jun 01 00:00:00 EDT 2022

Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects.

Biomedical reports

Choi H,Lee Y,Shin SH,Nam J,Park WS,Park BC,Kim BJ

14-5698-82 was used in Immunohistochemistry to demonstrate that inaudible sound at 30kHz significantly induces proliferative and anti-apoptotic effects in human dermal papilla cells (hDPCs) and outer root sheath keratinocytes.

Tue Mar 01 00:00:00 EST 2022

Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis.

Nature communications

Koren E,Feldman A,Yusupova M,Kadosh A,Sedov E,Ankawa R,Yosefzon Y,Nasser W,Gerstberger S,Kimel LB,Priselac N,Brown S,Sharma S,Gorenc T,Shalom-Feuerstein R,Steller H,Shemesh T,Fuchs Y

14-5698-82 was used in Immunohistochemistry to report a population of keratinocytes, marked by Thy1, in the basal layer of the interfollicular epidermis.

Mon Aug 08 00:00:00 EDT 2022

PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma.

Cancer research

Yi J,Kim B,Shi X,Zhan X,Lu QR,Xuan Z,Wu J

14-5698-82 was used in Immunohistochemistry to report that the histone H3K27 methyltransferase polycomb repressor complex 2 (PRC2) is often heterogeneous within individual SHH medulloblastoma tumors.

Tue Aug 16 00:00:00 EDT 2022

Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.

Cell reports

Luo F,Wang J,Zhang Z,You Z,Bedolla A,Okwubido-Williams F,Huang LF,Silver J,Luo Y

14-5698-82 was used in Immunohistochemistry to propose that CSPGs induced by stroke play a predominant role in the regulation of neural repair and that blocking CSPG signaling pathways will lead to enhanced neurorepair and functional recovery in stroke.

Tue Jul 26 00:00:00 EDT 2022

Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling.

Cellular and molecular gastroenterology and hepatology

Xie L,Fletcher RB,Bhatia D,Shah D,Phipps J,Deshmukh S,Zhang H,Ye J,Lee S,Le L,Newman M,Chen H,Sura A,Gupta S,Sanman LE,Yang F,Meng W,Baribault H,Vanhove GF,Yeh WC,Li Y,Lu C

14-5698-82 was used in Immunohistochemistry to demonstrate that SZN-1326-p directly impacted epithelial cells, driving transient expansion of stem and progenitor cells, promoting differentiation of epithelial cells, histologically restoring the damaged epithelium, and secondarily to epithelial repair, reducing inflammation.

Mon Jul 25 00:00:00 EDT 2022

Diane-35 and Metformin Induce Autophagy and Apoptosis in Polycystic Ovary Syndrome Women with Early-Stage Endometrial Carcinoma.

Genes

Liu Y,Wang Y,Yao D,Chen X,Zhang F,Feng Y,Li X

14-5698-82 was used in Immunohistochemistry to support the use of Diane-35 and metformin combination therapy for patients with PCOS and early EC.

Wed Jan 12 00:00:00 EST 2022

Lessons learned from pre-clinical testing of xenogeneic decellularized esophagi in a rabbit model.

iScience

Hannon E,Pellegrini M,Scottoni F,Durkin N,Shibuya S,Lutman R,Proctor TJ,Hutchinson JC,Arthurs OJ,Phylactopoulos DE,Maughan EF,Butler CR,Eaton S,Lowdell MW,Bonfanti P,Urbani L,De Coppi P

14-5698-82 was used in Immunohistochemistry to indicate that transplantation of a decellularized porcine scaffold is possible and vascular flaps may be useful to provide a vascular supply, but long-term outcomes require further pre-clinical testing in a different large animal model.

Fri Oct 21 00:00:00 EDT 2022

Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19.

Cell reports. Medicine

Feyaerts D,Hédou J,Gillard J,Chen H,Tsai ES,Peterson LS,Ando K,Manohar M,Do E,Dhondalay GKR,Fitzpatrick J,Artandi M,Chang I,Snow TT,Chinthrajah RS,Warren CM,Wittman R,Meyerowitz JG,Ganio EA,Stelzer IA,Han X,Verdonk F,Gaudillière DK,Mukherjee N,Tsai AS,Rumer KK,Jacobsen DR,Bjornson-Hooper ZB,Jiang S,Saavedra SF,Valdés Ferrer SI,Kelly JD,Furman D,Aghaeepour N,Angst MS,Boyd SD,Pinsky BA,Nolan GP,Nadeau KC,Gaudillière B,McIlwain DR

14-5698-82 was used in Flow cytometry/Cell sorting to provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for prevention and/or treatment of COVID-19 progression.

Tue Jul 19 00:00:00 EDT 2022

Oligodendrocyte progenitor proliferation is disinhibited following traumatic brain injury in leukemia inhibitory factor heterozygous mice.

Journal of neuroscience research

Frondelli MJ,Mather ML,Levison SW

14-5698-82 was used in Immunohistochemistry-immunofluorescence to provide new insights into the regulatory role of LIF in suppressing neural progenitor cell proliferation and, in particular, oligodendrocyte progenitor cell proliferation after a mild TBI.

Tue Feb 01 00:00:00 EST 2022

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells.

Nature

Casanova-Acebes M,Dalla E,Leader AM,LeBerichel J,Nikolic J,Morales BM,Brown M,Chang C,Troncoso L,Chen ST,Sastre-Perona A,Park MD,Tabachnikova A,Dhainaut M,Hamon P,Maier B,Sawai CM,Agulló-Pascual E,Schober M,Brown BD,Reizis B,Marron T,Kenigsberg E,Moussion C,Benaroch P,Aguirre-Ghiso JA,Merad M

14-5698-82 was used in Immunohistochemistry-immunofluorescence to explore the diversity of the macrophage compartment in human non-small cell lung carcinoma (NSCLC) lesions.

Thu Jul 01 00:00:00 EDT 2021

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

Nature neuroscience

Eze UC,Bhaduri A,Haeussler M,Nowakowski TJ,Kriegstein AR

14-5698-82 was used in Immunohistochemistry to provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.

Thu Apr 01 00:00:00 EDT 2021

Visualization of individual cell division history in complex tissues using iCOUNT.

Cell stem cell

Denoth-Lippuner A,Jaeger BN,Liang T,Royall LN,Chie SE,Buthey K,Machado D,Korobeynyk VI,Kruse M,Munz CM,Gerbaulet A,Simons BD,Jessberger S

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Nov 04 00:00:00 EDT 2021

Effect of cellular and ECM aging on human iPSC-derived cardiomyocyte performance, maturity and senescence.

Biomaterials

Ozcebe SG,Bahcecioglu G,Yue XS,Zorlutuna P

14-5698-82 was used in Immunocytochemistry to investigate the individual effects of cellular and environmental aging and identify the biochemical changes that occur upon cardiac aging.

Fri Jan 01 00:00:00 EST 2021

CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.

Autophagy

Keller CW,Kotur MB,Mundt S,Dokalis N,Ligeon LA,Shah AM,Prinz M,Becher B,Münz C,Lünemann JD

14-5698 was used in Immunohistochemistry to report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4+ T cells through LC3-associated phagocytosis (LAP).

Sat May 01 00:00:00 EDT 2021

Epicardial placement of human MSC-loaded fibrin sealant films for heart failure: Preclinical efficacy and mechanistic data.

Molecular therapy : the journal of the American Society of Gene Therapy

Fields L,Ito T,Kobayashi K,Ichihara Y,Podaru MN,Hussain M,Yamashita K,Machado V,Lewis-McDougall F,Suzuki K

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Wed Aug 04 00:00:00 EDT 2021

Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.

Glia

Götz S,Bribian A,López-Mascaraque L,Götz M,Grothe B,Kunz L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Feb 01 00:00:00 EST 2021

Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.

Glia

Götz S,Bribian A,López-Mascaraque L,Götz M,Grothe B,Kunz L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Feb 01 00:00:00 EST 2021

Heterogeneity of astrocytes: Electrophysiological properties of juxtavascular astrocytes before and after brain injury.

Glia

Götz S,Bribian A,López-Mascaraque L,Götz M,Grothe B,Kunz L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Feb 01 00:00:00 EST 2021

Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development.

Development (Cambridge, England)

Perelli RM,O'Sullivan ML,Zarnick S,Kay JN

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sat May 01 00:00:00 EDT 2021

Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development.

Development (Cambridge, England)

Perelli RM,O'Sullivan ML,Zarnick S,Kay JN

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sat May 01 00:00:00 EDT 2021

Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor.

Development (Cambridge, England)

Otsu K,Ida-Yonemochi H,Ikezaki S,Ema M,Hitomi J,Ohshima H,Harada H

14-5698-82 was used in Immunohistochemistry to study the role of molecular oxygen in regulating the proliferation of epithelial stem cells.

Mon Feb 15 00:00:00 EST 2021

CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains.

Development (Cambridge, England)

Kimura T,Saito H,Kawasaki M,Takeichi M

14-5698-82 was used in Immunohistochemistry to suggest that CAMSAP3 supports mTORC1 signaling required for ependymal cell growth via MT network regulation, and, in turn, shaping of the lateral ventricles.

Fri Feb 05 00:00:00 EST 2021

HDAC1 Regulates Neuronal Differentiation.

Frontiers in molecular neuroscience

Nieto-Estevez V,Changarathil G,Adeyeye AO,Coppin MO,Kassim RS,Zhu J,Hsieh J

14-5698-82 was used in Immunohistochemistry to decipher the role of individual histone deacetylases in adult hippocampal neurogenesis.

Tue Feb 01 00:00:00 EST 2022

Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure.

Frontiers in cell and developmental biology

Ying L,Zhang M,Ma X,Si Y,Li X,Su J,Yin J,Bao Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yamamoto A,Morioki H,Nakae T,Miyake Y,Harada T,Noda S,Mitsuoka S,Matsumoto K,Tomimatsu M,Kanemoto S,Tanaka S,Maeda M,Conway SJ,Imaizumi K,Fujio Y,Obana M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Feb 01 00:00:00 EST 2021

Transcription factor old astrocyte specifically induced substance is a novel regulator of kidney fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yamamoto A,Morioki H,Nakae T,Miyake Y,Harada T,Noda S,Mitsuoka S,Matsumoto K,Tomimatsu M,Kanemoto S,Tanaka S,Maeda M,Conway SJ,Imaizumi K,Fujio Y,Obana M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Feb 01 00:00:00 EST 2021

Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes.

Journal of molecular and cellular cardiology

Wang X,Lupton C,Lauth A,Wan TC,Foster P,Patterson M,Auchampach JA,Lough JW

14-5698-82 was used in Immunohistochemistry to indicate that, among its pleiotropic functions, Tip60 induces the DDR in CMs, contributing to proliferative senescence.

Tue Jun 01 00:00:00 EDT 2021

HIF-1α is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer.

Journal of cellular and molecular medicine

Zhang Y,Bian Y,Wang Y,Wang Y,Duan X,Han Y,Zhang L,Wang F,Gu Z,Qin Z

14-5698-82 was used in Immunohistochemistry, Immunocytochemistry to find that hypoxia-inducible factor-1α (HIF-1α) is highly expressed in CAFs of human lung cancer tissues and mouse spontaneous lung tumour.

Tue Jun 01 00:00:00 EDT 2021

HIF-1α is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer.

Journal of cellular and molecular medicine

Zhang Y,Bian Y,Wang Y,Wang Y,Duan X,Han Y,Zhang L,Wang F,Gu Z,Qin Z

Tue Jun 01 00:00:00 EDT 2021

HOXA11 plays critical roles in disease progression and response to cytarabine in AML.

Oncology reports

Fu JF,Shih LY,Yen TH

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Thrombospondin-2 spatiotemporal expression in skeletal fractures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zondervan RL,Jenkins DC,Reicha JD,Hankenson KD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Jan 01 00:00:00 EST 2021

Thrombospondin-2 spatiotemporal expression in skeletal fractures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zondervan RL,Jenkins DC,Reicha JD,Hankenson KD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Jan 01 00:00:00 EST 2021

MicroRNA-384 inhibits nasopharyngeal carcinoma growth and metastasis via binding to Smad5 and suppressing the Wnt/β-catenin axis.

Cytotechnology

Zeng X,Liao H,Wang F

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Apr 01 00:00:00 EDT 2021

MYBL2 in synergy with CDC20 promotes the proliferation and inhibits apoptosis of gastric cancer cells.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Deng Q,Wu L,Li Y,Zou L

14-5698-82 was used in Western Blot to examine the role of myeloblastosis viral oncogene homolog-like 2 (MYBL2) in gastric cancer progression and investigate the underlying mechanisms.

Wed Sep 01 00:00:00 EDT 2021

Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.

Life science alliance

Redl E,Sheibani-Tezerji R,Cardona CJ,Hamminger P,Timelthaler G,Hassler MR,Zrimšek M,Lagger S,Dillinger T,Hofbauer L,Draganić K,Tiefenbacher A,Kothmayer M,Dietz CH,Ramsahoye BH,Kenner L,Bock C,Seiser C,Ellmeier W,Schweikert G,Egger G

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Feb 01 00:00:00 EST 2021

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

Oncoimmunology

Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Ten-eleven translocation protein 1 modulates medulloblastoma progression.

Genome biology

Kim H,Kang Y,Li Y,Chen L,Lin L,Johnson ND,Zhu D,Robinson MH,McSwain L,Barwick BG,Yuan X,Liao X,Zhao J,Zhang Z,Shu Q,Chen J,Allen EG,Kenney AM,Castellino RC,Van Meir EG,Conneely KN,Vertino PM,Jin P,Li J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (Frozen)

Thu Apr 29 00:00:00 EDT 2021

Ten-eleven translocation protein 1 modulates medulloblastoma progression.

Genome biology

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (Frozen)

Thu Apr 29 00:00:00 EDT 2021

Ten-eleven translocation protein 1 modulates medulloblastoma progression.

Genome biology

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (Frozen)

Thu Apr 29 00:00:00 EDT 2021

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.

Oncoimmunology

Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia.

Cell reports

Suzuki S,McCarrey JR,Hermann BP

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia.

Cell reports

Suzuki S,McCarrey JR,Hermann BP

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

IL-1beta promotes the age-associated decline of beta cell function.

iScience

Böni-Schnetzler M,Méreau H,Rachid L,Wiedemann SJ,Schulze F,Trimigliozzi K,Meier DT,Donath MY

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Nov 19 00:00:00 EST 2021

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Nature communications

Fujino T,Goyama S,Sugiura Y,Inoue D,Asada S,Yamasaki S,Matsumoto A,Yamaguchi K,Isobe Y,Tsuchiya A,Shikata S,Sato N,Morinaga H,Fukuyama T,Tanaka Y,Fukushima T,Takeda R,Yamamoto K,Honda H,Nishimura EK,Furukawa Y,Shibata T,Abdel-Wahab O,Suematsu M,Kitamura T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

Shikonin Derivatives from Onsoma visianii Decrease Expression of Phosphorylated STAT3 in Leukemia Cells and Exert Antitumor Activity.

Nutrients

Todorovic Z,Milovanovic J,Arsenijevic D,Vukovic N,Vukic M,Arsenijevic A,Djurdjevic P,Milovanovic M,Arsenijevic N

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Mar 31 00:00:00 EDT 2021

Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation.

Frontiers in physiology

Koch PS,Sandorski K,Heil J,Schmid CD,Kürschner SW,Hoffmann J,Winkler M,Staniczek T,de la Torre C,Sticht C,Schledzewski K,Taketo MM,Trogisch FA,Heineke J,Géraud C,Goerdt S,Olsavszky V

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Oct 22 00:00:00 EDT 2021

CDCP1 promotes compensatory renal growth by integrating Src and Met signaling.

Life science alliance

Kajiwara K,Yamano S,Aoki K,Okuzaki D,Matsumoto K,Okada M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Apr 01 00:00:00 EDT 2021

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.

Cell reports

Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands.

International journal of molecular sciences

Kim J,Lee SW,Park K

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Sun Jan 10 00:00:00 EST 2021

CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands.

International journal of molecular sciences

Kim J,Lee SW,Park K

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Sun Jan 10 00:00:00 EST 2021

Delta-like 4 is required for pulmonary vascular arborization and alveolarization in the developing lung.

JCI insight

Xia S,Menden HL,Townley N,Mabry SM,Johnston J,Nyp MF,Heruth DP,Korfhagen T,Sampath V

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Apr 08 00:00:00 EDT 2021

Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.

Science advances

Shariq M,Sahasrabuddhe V,Krishna S,Radha S,Bellampalli R,Dwivedi A,Cheramangalam R,Reizis B,Hébert J,Ghosh HS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (PFA fixed)

Sat May 01 00:00:00 EDT 2021

Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.

Science advances

Shariq M,Sahasrabuddhe V,Krishna S,Radha S,Bellampalli R,Dwivedi A,Cheramangalam R,Reizis B,Hébert J,Ghosh HS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (PFA fixed)

Sat May 01 00:00:00 EDT 2021

Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.

Science advances

Shariq M,Sahasrabuddhe V,Krishna S,Radha S,Bellampalli R,Dwivedi A,Cheramangalam R,Reizis B,Hébert J,Ghosh HS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry (PFA fixed)

Sat May 01 00:00:00 EDT 2021

Notch Signaling between Cerebellar Granule Cell Progenitors.

eNeuro

Adachi T,Miyashita S,Yamashita M,Shimoda M,Okonechnikov K,Chavez L,Kool M,Pfister SM,Inoue T,Kawauchi D,Hoshino M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Jul 02 00:00:00 EDT 2021

Notch Signaling between Cerebellar Granule Cell Progenitors.

eNeuro

Adachi T,Miyashita S,Yamashita M,Shimoda M,Okonechnikov K,Chavez L,Kool M,Pfister SM,Inoue T,Kawauchi D,Hoshino M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Jul 02 00:00:00 EDT 2021

Developmental Role of Adenosine Kinase in the Cerebellum.

eNeuro

Gebril H,Wahba A,Zhou X,Lai T,Alharfoush E,DiCicco-Bloom E,Boison D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Jul 02 00:00:00 EDT 2021

Field size effects on DNA damage and proliferation in normal human cell populations irradiated with X-ray microbeams.

Scientific reports

Ojima M,Ito A,Usami N,Ohara M,Suzuki K,Kai M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Mar 26 00:00:00 EDT 2021

Field size effects on DNA damage and proliferation in normal human cell populations irradiated with X-ray microbeams.

Scientific reports

Ojima M,Ito A,Usami N,Ohara M,Suzuki K,Kai M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Mar 26 00:00:00 EDT 2021

Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation.

eLife

Sela Y,Li J,Kuri P,Merrell AJ,Li N,Lengner C,Rompolas P,Stanger BZ

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Feb 23 00:00:00 EST 2021

Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation.

eLife

Sela Y,Li J,Kuri P,Merrell AJ,Li N,Lengner C,Rompolas P,Stanger BZ

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Feb 23 00:00:00 EST 2021

NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype.

Scientific reports

Karlsen TR,Kong XY,Holm S,Quiles-Jiménez A,Dahl TB,Yang K,Sagen EL,Skarpengland T,S Øgaard JD,Holm K,Vestad B,Olsen MB,Aukrust P,Bjørås M,Hov JR,Halvorsen B,Gregersen I

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Tue Oct 05 00:00:00 EDT 2021

GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma.

Journal of orthopaedic surgery and research

Xie C,Xiang W,Shen H,Shen J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Dec 07 00:00:00 EST 2021

Cell death & disease

Catlin JP,Marziali LN,Rein B,Yan Z,Feltri ML,Schaner Tooley CE

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Oct 28 00:00:00 EDT 2021

TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression.

Cells

Kwon O,Yang H,Kim SC,Kim J,Sim J,Lee J,Hwang EM,Shim S,Park JY

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Oct 14 00:00:00 EDT 2021

Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling.

Cancers

Zhang X,Huang Z,Wang J,Ma Z,Yang J,Corey E,Evans CP,Yu AM,Chen HW

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Apr 01 00:00:00 EDT 2021

A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.

Med (New York, N.Y.)

Silva-Cayetano A,Foster WS,Innocentin S,Belij-Rammerstorfer S,Spencer AJ,Burton OT,Fra-Bidó S,Le Lee J,Thakur N,Conceicao C,Wright D,Barrett J,Evans-Bailey N,Noble C,Bailey D,Liston A,Gilbert SC,Lambe T,Linterman MA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Mar 12 00:00:00 EST 2021

Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases.

Frontiers in medicine

Verhulst S,van Os EA,De Smet V,Eysackers N,Mannaerts I,van Grunsven LA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Wed Nov 10 00:00:00 EST 2021

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.

Nature communications

Little DR,Lynch AM,Yan Y,Akiyama H,Kimura S,Chen J

14-5698-82 was used in Immunocytochemistry to report that the cell-type-specific function of NKX2-1 is attributed to its differential chromatin binding that is acquired or retained during development in coordination with partner transcriptional factors.

Tue May 04 00:00:00 EDT 2021

An in vivo model allowing continuous observation of human vascular formation in the same animal over time.

Scientific reports

Tsukada Y,Muramatsu F,Hayashi Y,Inagaki C,Su H,Iba T,Kidoya H,Takakura N

14-5698 was used in Immunohistochemistry-immunofluorescence to develop a human blood vessel model in mice for understanding human blood vessel formation mechanisms and the effects of drugs that target human blood vessels in vivo.

Tue Jan 12 00:00:00 EST 2021

Adipose mesenchymal stem cells-secreted extracellular vesicles containing microRNA-192 delays diabetic retinopathy by targeting ITGA1.

Journal of cellular physiology

Gu C,Zhang H,Gao Y

14-5698-82 was used in Immunohistochemistry-immunofluorescence to establish that miR-192 released by Evs from MSCs could delay the events of the inflammatory response and angiogenesis in Diabetic retinopathy (DR) and may represent a possible therapeutic approach for the treatment of DR.

Thu Jul 01 00:00:00 EDT 2021

A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.

Neuron

Chen J,Lambo ME,Ge X,Dearborn JT,Liu Y,McCullough KB,Swift RG,Tabachnick DR,Tian L,Noguchi K,Garbow JR,Constantino JN,Gabel HW,Hengen KB,Maloney SE,Dougherty JD

14-5698-82 was used in Immunohistochemistry-immunofluorescence to provide insight into the mechanistic underpinnings of this disorder and enable future preclinical studies.

Wed Dec 01 00:00:00 EST 2021

Impairment of type H vessels by NOX2-mediated endothelial oxidative stress: critical mechanisms and therapeutic targets for bone fragility in streptozotocin-induced type 1 diabetic mice.

Theranostics

Hu XF,Xiang G,Wang TJ,Ma YB,Zhang Y,Yan YB,Zhao X,Wu ZX,Feng YF,Lei W

14-5698 was used in Immunohistochemistry-immunofluorescence to propose that the impairment of type H vessels by NOX2-mediated endothelial oxidative stress might be an important contributor to type 1 diabetes mellitus-induced osteopathy.

Thu Jul 29 00:00:00 EDT 2021

Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of In Vivo Fallopian Tube Electroporation and CRISPR-Cas9-Mediated Genome Editing.

Cancer research

Teng K,Ford MJ,Harwalkar K,Li Y,Pacis AS,Farnell D,Yamanaka N,Wang YC,Badescu D,Ton Nu TN,Ragoussis J,Huntsman DG,Arseneau J,Yamanaka Y

14-5698-82 was used in Immunohistochemistry to unveil a new strategy to generate genetic mouse models of ovarian cancer with high flexibility in selecting mutation combinations and targeting areas.

Fri Oct 15 00:00:00 EDT 2021

IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting αSMA.

Cell death & disease

Ock S,Ham W,Kang CW,Kang H,Lee WS,Kim J

14-5698-82 was used in Immunohistochemistry to propose that low-dose IGF-1 may be an efficacious therapeutic avenue against cardiac fibrosis.

Fri Jul 09 00:00:00 EDT 2021

Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus.

Nature communications

Zocher S,Overall RW,Lesche M,Dahl A,Kempermann G

14-5698-82 was used in Immunohistochemistry to show that experiencing a stimulus-rich environment counteracts age-related DNA methylation changes in the hippocampal dentate gyrus of mice.

Wed Jun 23 00:00:00 EDT 2021

Treatment of necrotizing enterocolitis by conditioned medium derived from human amniotic fluid stem cells.

PloS one

O'Connell JS,Li B,Zito A,Ahmed A,Cadete M,Ganji N,Lau E,Alganabi M,Farhat N,Lee C,Eaton S,Mitchell R,Ray S,De Coppi P,Patel K,Pierro A

14-5698-82 was used in Immunohistochemistry-immunofluorescence to show that CM derived from human AFSC administered in experimental NEC exhibited various benefits including reduced intestinal injury and inflammation, increased enterocyte proliferation, and restored intestinal stem cell activity.

Thu Jan 06 00:00:00 EST 2022

Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity.

Cancer cell

Pearson JD,Huang K,Pacal M,McCurdy SR,Lu S,Aubry A,Yu T,Wadosky KM,Zhang L,Wang T,Gregorieff A,Ahmad M,Dimaras H,Langille E,Cole SPC,Monnier PP,Lok BH,Tsao MS,Akeno N,Schramek D,Wikenheiser-Brokamp KA,Knudsen ES,Witkiewicz AK,Wrana JL,Goodrich DW,Bremner R

14-5698-82 was used in Immunohistochemistry (PFA fixed) to show that YAP is thus pivotal across cancer, but in opposite ways, with therapeutic implications.

Mon Aug 09 00:00:00 EDT 2021

Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia.

Microbiome

Vicentini FA,Keenan CM,Wallace LE,Woods C,Cavin JB,Flockton AR,Macklin WB,Belkind-Gerson J,Hirota SA,Sharkey KA

14-5698-82 was used in Immunohistochemistry-immunofluorescence to reveal new insights into the role of the gut microbiota that could lead to therapeutic developments for the treatment of enteric neuropathies.

Tue Oct 26 00:00:00 EDT 2021

Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures.

eLife

Gkatzis K,Panza P,Peruzzo S,Stainier DY

14-5698-82 was used in Immunocytochemistry to understand how serum-free culture conditions effect alveolar cell differentiation into mouse-modelled lung organoids.

Wed Sep 29 00:00:00 EDT 2021

Notch signaling drives development of Barrett's metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa.

Scientific reports

Kunze B,Middelhoff M,Maurer HC,Agibalova T,Anand A,Bührer AM,Fang HY,Baumeister T,Steiger K,Strangmann J,Schmid RM,Wang TC,Quante M

14-5698-82 was used in Immunohistochemistry to show that Notch activation in Dclk1-positive tuft cells in the gastric cardia can contribute to BE development.

Wed Feb 24 00:00:00 EST 2021

Jazf1 acts as a regulator of insulin-producing β-cell differentiation in induced pluripotent stem cells and glucose homeostasis in mice.

The FEBS journal

Park SJ,Kwon W,Park S,Jeong J,Kim D,Jang S,Kim SY,Sung Y,Kim MO,Choi SK,Ryoo ZY

14-5698-82 was used in Immunohistochemistry to demonstrate that Jazf1 plays a pivotal role in the differentiation of β-cells and glucose homeostasis.

Thu Jul 01 00:00:00 EDT 2021

Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells.

Cell

Wu H,Yu Y,Huang H,Hu Y,Fu S,Wang Z,Shi M,Zhao X,Yuan J,Li J,Yang X,Bin E,Wei D,Zhang H,Zhang J,Yang C,Cai T,Dai H,Chen J,Tang N

14-5698-82 was used in Immunohistochemistry (PFA fixed) to discover that loss of Cdc42 function in alveolar stem cells (AT2 cells) causes periphery-to-center progressive lung fibrosis.

Thu Jan 09 00:00:00 EST 2020

MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype.

Cancer discovery

Sodir NM,Kortlever RM,Barthet VJA,Campos T,Pellegrinet L,Kupczak S,Anastasiou P,Swigart LB,Soucek L,Arends MJ,Littlewood TD,Evan GI

14-5698-82 was used in Immunohistochemistry to demonstrate that this Myc-driven PDAC switch is completely and immediately reversible: Myc deactivation/inhibition triggers meticulous disassembly of advanced PDAC tumor and stroma and concomitant death of tumor cells.

Wed Apr 01 00:00:00 EDT 2020

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Cell stem cell

Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Dec 03 00:00:00 EST 2020

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Cell stem cell

Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Dec 03 00:00:00 EST 2020

Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Cell stem cell

Katsura H,Sontake V,Tata A,Kobayashi Y,Edwards CE,Heaton BE,Konkimalla A,Asakura T,Mikami Y,Fritch EJ,Lee PJ,Heaton NS,Boucher RC,Randell SH,Baric RS,Tata PR

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Dec 03 00:00:00 EST 2020

In Vivo Lineage Tracing of Polyploid Hepatocytes Reveals Extensive Proliferation during Liver Regeneration.

Cell stem cell

Matsumoto T,Wakefield L,Tarlow BD,Grompe M

14-5698 was used in Immunocytochemistry-immunoflourescence to study the regenerative capacity of polyploid hepatocytes during liver regeneration.

Thu Jan 02 00:00:00 EST 2020

A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury.

Cell stem cell

Zamboni M,Llorens-Bobadilla E,Magnusson JP,Frisén J

14-5698-82 was used in Immunohistochemistry to show that cortical neurogenesis molecularly recapitulates canonical subventricular zone neurogenesis with remarkable fidelity.

Thu Oct 01 00:00:00 EDT 2020

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.

Cell stem cell

Choi J,Park JE,Tsagkogeorga G,Yanagita M,Koo BK,Han N,Lee JH

14-5698-82 was used in Immunohistochemistry (Paraffin) to map the trajectories of alveolar-lineage cells during injury repair and lung regeneration by single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models.

Thu Sep 03 00:00:00 EDT 2020

Myofibroblast contraction is essential for generating and regenerating the gas-exchange surface.

The Journal of clinical investigation

Li R,Li X,Hagood J,Zhu MS,Sun X

14-5698 was used in Immunohistochemistry to show that inactivation of myosin light chain kinase (MLCK), a key factor required for myofibroblast contraction, disrupted septa formation, supporting the myofibroblast contraction model of alveologenesis.

Mon Jun 01 00:00:00 EDT 2020

Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity.

The Journal of clinical investigation

Wagner CA,Roqué PJ,Mileur TR,Liggitt D,Goverman JM

14-5698-82 was used in Flow Cytometry to suggest that myelin-specific CD8+ T cells may contribute to disease pathogenesis via a FasL-dependent mechanism that preferentially promotes lesion formation in the brain.

Thu Jan 02 00:00:00 EST 2020

Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.

Nucleic acids research

Wüst HM,Wegener A,Fröb F,Hartwig AC,Wegwitz F,Kari V,Schimmel M,Tamm ER,Johnsen SA,Wegner M,Sock E

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Sep 18 00:00:00 EDT 2020

Egr2-guided histone H2B monoubiquitination is required for peripheral nervous system myelination.

Nucleic acids research

Wüst HM,Wegener A,Fröb F,Hartwig AC,Wegwitz F,Kari V,Schimmel M,Tamm ER,Johnsen SA,Wegner M,Sock E

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Sep 18 00:00:00 EDT 2020

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.

The Journal of experimental medicine

Hermanova I,Zúñiga-García P,Caro-Maldonado A,Fernandez-Ruiz S,Salvador F,Martín-Martín N,Zabala-Letona A,Nuñez-Olle M,Torrano V,Camacho L,Lizcano JM,Talamillo A,Carreira S,Gurel B,Cortazar AR,Guiu M,López JI,Martinez-Romero A,Astobiza I,Valcarcel-Jimenez L,Lorente M,Arruabarrena-Aristorena A,Velasco G,Gomez-Muñoz A,Suárez-Cabrera C,Lodewijk I,Flores JM,Sutherland JD,Barrio R,de Bono JS,Paramio JM,Trka J,Graupera M,Gomis RR,Carracedo A

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.

The Journal of experimental medicine

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung.

Developmental cell

Vila Ellis L,Cain MP,Hutchison V,Flodby P,Crandall ED,Borok Z,Zhou B,Ostrin EJ,Wythe JD,Chen J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Mar 09 00:00:00 EDT 2020

NiCHE Platform: Nature-Inspired Catechol-Conjugated Hyaluronic Acid Environment Platform for Salivary Gland Tissue Engineering.

ACS applied materials & interfaces

Lee SW,Ryu JH,Do MJ,Namkoong E,Lee H,Park K

14-5698-82 was used in Immunocytochemistry to model an optimum artificial microenvironment to allow for salivary gland tissue engineering.

Wed Jan 29 00:00:00 EST 2020

Administration of all-trans retinoic acid after experimental traumatic brain injury is brain protective.

British journal of pharmacology

Hummel R,Ulbrich S,Appel D,Li S,Hirnet T,Zander S,Bobkiewicz W,Gölz C,Schäfer MKE

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sun Nov 01 00:00:00 EDT 2020

Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma.

Glia

Alexander J,LaPlant QC,Pattwell SS,Szulzewsky F,Cimino PJ,Caruso FP,Pugliese P,Chen Z,Chardon F,Hill AJ,Spurrell C,Ahrendsen D,Pietras A,Starita LM,Hambardzumyan D,Iavarone A,Shendure J,Holland EC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma.

Glia

Alexander J,LaPlant QC,Pattwell SS,Szulzewsky F,Cimino PJ,Caruso FP,Pugliese P,Chen Z,Chardon F,Hill AJ,Spurrell C,Ahrendsen D,Pietras A,Starita LM,Hambardzumyan D,Iavarone A,Shendure J,Holland EC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Dec 01 00:00:00 EST 2020

GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer.

International journal of cancer

Sawada Y,Kikugawa T,Iio H,Sakakibara I,Yoshida S,Ikedo A,Yanagihara Y,Saeki N,Győrffy B,Kishida T,Okubo Y,Nakamura Y,Miyagi Y,Saika T,Imai Y

14-5698-82 was used in Immunohistochemistry (Paraffin) to to investigate if GPRC5A can be a possible therapeutic target and prognostic marker molecule for progressive prostate cancer.

Sun Mar 01 00:00:00 EST 2020

FGF2 modulates simultaneously the mode, the rate of division and the growth fraction in cultures of radial glia.

Development (Cambridge, England)

Ledesma-Terrón M,Peralta-Cañadas N,Míguez DG

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Jul 24 00:00:00 EDT 2020

FGF2 modulates simultaneously the mode, the rate of division and the growth fraction in cultures of radial glia.

Development (Cambridge, England)

Ledesma-Terrón M,Peralta-Cañadas N,Míguez DG

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Jul 24 00:00:00 EDT 2020

NPC1 deficiency impairs cerebellar postnatal development of microglia and climbing fiber refinement in a mouse model of Niemann-Pick disease type C.

Development (Cambridge, England)

Boyle BR,Melli SE,Altreche RS,Padron ZM,Yousufzai FAK,Kim S,Vasquez MD,Carone DM,Carone BR,Soto I

14-5698 was used in Immunohistochemistry to analyse the effect of NPC1 deficiency on microglia and on climbing fiber synaptic refinement during cerebellar postnatal development using the Npc1nmf164 mouse.

Mon Aug 03 00:00:00 EDT 2020

Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.

Development (Cambridge, England)

Sayols S,Klassek J,Werner C,Möckel S,Ritz S,Mendez-Lago M,Soshnikova N

14-5698 was used in Immunohistochemistry to assess whether Axin2- and Lgr5-expressing cells are gastric progenitors in the developing mouse stomach.

Tue Sep 15 00:00:00 EDT 2020

Oxidative stress regulates progenitor behavior and cortical neurogenesis.

Development (Cambridge, England)

Chui A,Zhang Q,Dai Q,Shi SH

14-5698 was used in Immunohistochemistry to suggest that oxidative stress actively regulates RGP behavior to ensure proper neurogenesis in the mammalian cortex.

Wed Mar 11 00:00:00 EDT 2020

Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Reed CB,Frick LR,Weaver A,Sidoli M,Schlant E,Feltri ML,Wrabetz L

14-5698-82 was used in Immunohistochemistry (Frozen) to assess the effects of CnB ablation on peripheral myelination after birth in both male and female mice.

Wed Aug 05 00:00:00 EDT 2020

Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Jhelum P,Santos-Nogueira E,Teo W,Haumont A,Lenoël I,Stys PK,David S

14-5698-82 was used in Immunocytochemistry to show that giving mice (male) CZ in the diet induces rapid loss of OL in the corpus callosum by 2 d, accompanied by expression of several markers for ferroptosis, a relatively newly described form of iron-mediated cell death.

Wed Nov 25 00:00:00 EST 2020

Novel enhanced GFP-positive congenic inbred strain establishment and application of tumor-bearing nude mouse model.

Cancer science

Lan Q,Chen Y,Dai C,Li S,Fei X,Dong J,Shen Y,Dai X,Lu Z,Liu B,Wang Q,Wang H,Zhou Z,Ji X,Wang Z,Huang Q

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Oct 01 00:00:00 EDT 2020

Novel enhanced GFP-positive congenic inbred strain establishment and application of tumor-bearing nude mouse model.

Cancer science

Lan Q,Chen Y,Dai C,Li S,Fei X,Dong J,Shen Y,Dai X,Lu Z,Liu B,Wang Q,Wang H,Zhou Z,Ji X,Wang Z,Huang Q

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Oct 01 00:00:00 EDT 2020

Mycobacterium tuberculosis-infected alveolar epithelial cells modulate dendritic cell function through the HIF-1α-NOS2 axis.

Journal of leukocyte biology

Rodrigues TS,Alvarez ARP,Gembre AF,Forni MFPAD,de Melo BMS,Alves Filho JCF,Câmara NOS,Bonato VLD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Deletion of Ppard in CD11c⁺ cells attenuates atherosclerosis in ApoE knockout mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Tian D,Hong H,Shang W,Ho CC,Dong J,Tian XY

14-5698-82 was used in Flow Cytometry to study the involvement of PPARδ in CD11c+ cells in atherosclerosis.

Sat Feb 01 00:00:00 EST 2020

Angiocrine Hepatocyte Growth Factor Signaling Controls Physiological Organ and Body Size and Dynamic Hepatocyte Proliferation to Prevent Liver Damage during Regeneration.

The American journal of pathology

Zhang XJ,Olsavszky V,Yin Y,Wang B,Engleitner T,Öllinger R,Schledzewski K,Koch PS,Rad R,Schmid RM,Friess H,Goerdt S,Hüser N,Géraud C,von Figura G,Hartmann D

14-5698-82 was used in Immunocytochemistry-immunoflourescence to aim to elucidate the precise contribution of Liver sinusoidal endothelial cells-derived hepatocyte growth factor in physiological homeostasis and liver regeneration.

Sat Feb 01 00:00:00 EST 2020

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma.

Frontiers in oncology

Gupta K,Vuckovic I,Zhang S,Xiong Y,Carlson BL,Jacobs J,Olson I,Petterson XM,Macura SI,Sarkaria J,Burns TC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Sep 28 00:00:00 EDT 2020

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma.

Frontiers in oncology

Gupta K,Vuckovic I,Zhang S,Xiong Y,Carlson BL,Jacobs J,Olson I,Petterson XM,Macura SI,Sarkaria J,Burns TC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Sep 28 00:00:00 EDT 2020

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma.

Frontiers in oncology

Gupta K,Vuckovic I,Zhang S,Xiong Y,Carlson BL,Jacobs J,Olson I,Petterson XM,Macura SI,Sarkaria J,Burns TC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Mon Sep 28 00:00:00 EDT 2020

Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone.

Molecular neurobiology

Zhang Z,Manaf A,Li Y,Perez SP,Suganthan R,Dahl JA,Bjørås M,Klungland A

14-5698 was used in Immunocytochemistry-immunoflourescence to define different subtypes of neural stem/progenitor cells (NSPCs) by individual histone methylations.

Sat Feb 01 00:00:00 EST 2020

Renewal and Differentiation of GCD Necklace Olfactory Sensory Neurons.

Chemical senses

Bloom ML,Johnston LB,Datta SR

14-5698-82 was used in Immunohistochemistry to demonstrate that-like their canonical counterparts-GCD OSNs undergo continuous renewal and define a GCD-specific developmental trajectory linking neurogenesis, maturation, and migration.

Fri May 29 00:00:00 EDT 2020

Agrin Promotes Limbal Stem Cell Proliferation and Corneal Wound Healing Through Hippo-Yap Signaling Pathway.

Investigative ophthalmology & visual science

Hou L,Fu W,Liu Y,Wang Q,Wang L,Huang Y

14-5698 was used in Immunocytochemistry to show how agrin promotes the proliferation of limbal stem cells and accelerates the healing rate of cornceal would through Hippo-Yap signalling pathway.

Mon May 11 00:00:00 EDT 2020

Comparing the fate of brain metastatic breast cancer cells in different immune compromised mice with cellular magnetic resonance imaging.

Clinical & experimental metastasis

Knier NN,Hamilton AM,Foster PJ

14-5698-82 was used in Immunohistochemistry to track the fate of a mammary carcinoma cell line (MDA-MB-231-BR) in vivo to characterize the growth of brain metastases in the nude and severely immune-compromised NOD/SCID/ILIIrg-/- (NSG) mouse.

Sat Aug 01 00:00:00 EDT 2020

Creation of Laryngeal Grafts from Primary Human Cells and Decellularized Laryngeal Scaffolds.

Tissue engineering. Part A

Moser PT,Gerli M,Diercks GR,Evangelista-Leite D,Charest JM,Gershlak JR,Ren X,Gilpin SE,Jank BJ,Gaudette GR,Hartnick CJ,Ott HC

14-5698 was used in Immunohistochemistry to report the de novo formation of three humanized laryngeal tissue compartments under one uniform culture condition, a possible keystone in creating vital composite tissue grafts for laryngeal regeneration.

Fri May 01 00:00:00 EDT 2020

Multidimensional hydrogel models reveal endothelial network angiocrine signals increase glioblastoma cell number, invasion, and temozolomide resistance.

Integrative biology : quantitative biosciences from nano to macro

Ngo MT,Karvelis E,Harley BAC

14-5698 was used in Immunocytochemistry-immunoflourescence to highlight the use of multidimensional hydrogel models to evaluate the role of angiocrine signals in glioblastoma progression.

Fri Jun 19 00:00:00 EDT 2020

Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway.

Clinical and experimental pharmacology & physiology

Bose P,Siddique MUM,Acharya R,Jayaprakash V,Sinha BN,Lapenna A,Pattanayak SP

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Wed Jan 01 00:00:00 EST 2020

New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney.

Acta histochemica et cytochemica

Haraguchi R,Kohara Y,Matsubayashi K,Kitazawa R,Kitazawa S

14-5698 was used in Immunohistochemistry-immunofluorescence to study new mechanisms involved in the pathogenesis of diabetic nephropathy.

Tue Apr 28 00:00:00 EDT 2020

Chemosensitization of prostate cancer stem cells in mice by angiogenin and plexin-B2 inhibitors.

Communications biology

Li S,Goncalves KA,Lyu B,Yuan L,Hu GF

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Jan 15 00:00:00 EST 2020

A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons.

eLife

Okaty BW,Sturrock N,Escobedo Lozoya Y,Chang Y,Senft RA,Lyon KA,Alekseyenko OV,Dymecki SM

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Jun 22 00:00:00 EDT 2020

A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons.

eLife

Okaty BW,Sturrock N,Escobedo Lozoya Y,Chang Y,Senft RA,Lyon KA,Alekseyenko OV,Dymecki SM

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Jun 22 00:00:00 EDT 2020

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell reports

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Jan 21 00:00:00 EST 2020

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell reports

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Jan 21 00:00:00 EST 2020

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs.

Nature communications

Pein M,Insua-Rodríguez J,Hongu T,Riedel A,Meier J,Wiedmann L,Decker K,Essers MAG,Sinn HP,Spaich S,Sütterlin M,Schneeweiss A,Trumpp A,Oskarsson T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Mar 20 00:00:00 EDT 2020

Aripiprazole reduces liver cell division.

PloS one

Pirc Marolt T,Kramar B,Bulc Rozman K,Šuput D,Milisav I

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Tue Dec 08 00:00:00 EST 2020

Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2.

Science advances

Zhao G,Weiner AI,Neupauer KM,de Mello Costa MF,Palashikar G,Adams-Tzivelekidis S,Mangalmurti NS,Vaughan AE

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Sun Nov 01 00:00:00 EDT 2020

Transcriptome analysis of basic fibroblast growth factor treated stem cells isolated from human exfoliated deciduous teeth.

Heliyon

Nowwarote N,Manokawinchoke J,Kanjana K,Fournier BPJ,Sukarawan W,Osathanon T

14-5698-82 was used in Immunocytochemistry to determine the bFGF target genes in stem cells isolated from human exfoliated deciduous teeth (SHEDs).

Mon Jun 01 00:00:00 EDT 2020

Transcriptome analysis of basic fibroblast growth factor treated stem cells isolated from human exfoliated deciduous teeth.

Heliyon

Nowwarote N,Manokawinchoke J,Kanjana K,Fournier BPJ,Sukarawan W,Osathanon T

14-5698-82 was used in Immunocytochemistry to determine the bFGF target genes in stem cells isolated from human exfoliated deciduous teeth (SHEDs).

Mon Jun 01 00:00:00 EDT 2020

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Jun 11 00:00:00 EDT 2020

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Jun 11 00:00:00 EDT 2020

The effects of hedgehog ligand neutralising antibody 5E1 in a mouse model of endometriosis.

BMC research notes

Cousins FL,Farley JK,Kerrigan R,Mukherjee S,Darzi S,Gargett CE,Deane JA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Sep 25 00:00:00 EDT 2020

CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Nature communications

Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

B Cell Activating Factor (BAFF) Is Required for the Development of Intra-Renal Tertiary Lymphoid Organs in Experimental Kidney Transplantation in Rats.

International journal of molecular sciences

Steines L,Poth H,Herrmann M,Schuster A,Banas B,Bergler T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Wed Oct 28 00:00:00 EDT 2020

Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation.

Cell reports. Medicine

Smith DK,Kates L,Durinck S,Patel N,Stawiski EW,Kljavin N,Foreman O,Sipos B,Solloway MJ,Allan BB,Peterson AS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Aug 25 00:00:00 EDT 2020

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.

eLife

Matsumoto N,Tanaka S,Horiike T,Shinmyo Y,Kawasaki H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Tue Apr 21 00:00:00 EDT 2020

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.

eLife

Matsumoto N,Tanaka S,Horiike T,Shinmyo Y,Kawasaki H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Tue Apr 21 00:00:00 EDT 2020

A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.

eLife

Matsumoto N,Tanaka S,Horiike T,Shinmyo Y,Kawasaki H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Tue Apr 21 00:00:00 EDT 2020

Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction.

PloS one

Gladow N,Hollmann C,Ramos G,Frantz S,Kerkau T,Beyersdorf N,Hofmann U

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Cardiac fibroblast proliferation rates and collagen expression mature early and are unaltered with advancing age.

JCI insight

Wu R,Ma F,Tosevska A,Farrell C,Pellegrini M,Deb A

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Dec 17 00:00:00 EST 2020

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow.

Nature communications

Riedel R,Addo R,Ferreira-Gomes M,Heinz GA,Heinrich F,Kummer J,Greiff V,Schulz D,Klaeden C,Cornelis R,Menzel U,Kröger S,Stervbo U,Köhler R,Haftmann C,Kühnel S,Lehmann K,Maschmeyer P,McGrath M,Naundorf S,Hahne S,Sercan-Alp Ö,Siracusa F,Stefanowski J,Weber M,Westendorf K,Zimmermann J,Hauser AE,Reddy ST,Durek P,Chang HD,Mashreghi MF,Radbruch A

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Changes in Liver Mechanical Properties and Water Diffusivity During Normal Pregnancy Are Driven by Cellular Hypertrophy.

Frontiers in physiology

Garczyńska K,Tzschätzsch H,Kühl AA,Morr AS,Lilaj L,Häckel A,Schellenberger E,Berndt N,Holzhütter HG,Braun J,Sack I,Guo J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Dec 18 00:00:00 EST 2020

Interleukin-13 disrupts type 2 pneumocyte stem cell activity.

JCI insight

Glisinski KM,Schlobohm AJ,Paramore SV,Birukova A,Moseley MA,Foster MW,Barkauskas CE

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Jan 16 00:00:00 EST 2020

Interleukin-13 disrupts type 2 pneumocyte stem cell activity.

JCI insight

Glisinski KM,Schlobohm AJ,Paramore SV,Birukova A,Moseley MA,Foster MW,Barkauskas CE

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Jan 16 00:00:00 EST 2020

Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer.

Cell death & disease

Charan M,Das S,Mishra S,Chatterjee N,Varikuti S,Kaul K,Misri S,Ahirwar DK,Satoskar AR,Ganju RK

14-5698 was used in Immunohistochemistry to study the role of Macrophage migration inhibitory factor (MIF) in Triple-negative breast cancer (TNBC) progression and metastasis.

Thu Sep 17 00:00:00 EDT 2020

Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.

Toxicological sciences : an official journal of the Society of Toxicology

Nudischer R,Renggli K,Bertinetti-Lapatki C,Hoflack JC,Flint N,Sewing S,Pedersen L,Schadt S,Higgins LG,Vardy A,Lenz B,Gand L,Boess F,Elcombe BM,Hierlemann A,Roth AB

14-5698 was used in Immunohistochemistry to suggest RG7090 to be a rodent-specific CAR activator, and that CAR activation and its downstream processes were involved in the foci of altered hepatocytes formation detected in vivo.

Sat Aug 01 00:00:00 EDT 2020

Pro-myogenic small molecules revealed by a chemical screen on primary muscle stem cells.

Skeletal muscle

Buchanan SM,Price FD,Castiglioni A,Gee AW,Schneider J,Matyas MN,Hayhurst M,Tabebordbar M,Wagers AJ,Rubin LL

14-5698 was used in Immunocytochemistry-immunoflourescence to identify new pathways that can prevent loss of skeletal muscle function or enhance regenerative potential.

Fri Oct 09 00:00:00 EDT 2020

Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function.

iScience

Lee JS,Wang RX,Goldberg MS,Clifford GP,Kao DJ,Colgan SP

14-5698-82 was used in Immunohistochemistry (Paraffin) to reveal the gut microbiota as a prominent source of exogenous purines and that such microbiota-sourced purines (MSPs) are available to the intestinal mucosa.

Fri Jun 26 00:00:00 EDT 2020

Regulation of stem/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation.

eLife

Tremblay M,Viala S,Shafer ME,Graham-Paquin AL,Liu C,Bouchard M

14-5698 was used in Immunohistochemistry-immunofluorescence to explore the regulation of stem / progenitor cell homeostasis by BMP5.

Mon Sep 07 00:00:00 EDT 2020

Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution.

eLife

Orsenigo F,Conze LL,Jauhiainen S,Corada M,Lazzaroni F,Malinverno M,Sundell V,Cunha SI,Brännström J,Globisch MA,Maderna C,Lampugnani MG,Magnusson PU,Dejana E

14-5698-82 was used in Immunocytochemistry to comprehensively characterize subclasses of brain endothelial cells (ECs) under both normal conditions and after deletion of Pdcd10 (Ccm3) in a mouse model of CCM.

Tue Nov 03 00:00:00 EST 2020

The neuroregenerative effects of topical decorin on the injured mouse cornea.

Journal of neuroinflammation

Wu M,Downie LE,Grover LM,Moakes RJA,Rauz S,Logan A,Jiao H,Hill LJ,Chinnery HR

14-5698 was used in Immunohistochemistry-wholemount to support a role for decorin in DC-mediated neuroregeneration following corneal abrasion injury.

Mon May 04 00:00:00 EDT 2020

Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer.

Cancers

Bauman JE,Ohr J,Gooding WE,Ferris RL,Duvvuri U,Kim S,Johnson JT,Soloff AC,Wallweber G,Winslow J,Gaither-Davis A,Grandis JR,Stabile LP

14-5698-82 was used in Flow Cytometry to establish the recommended Phase II dose (RP2D). Secondary objectives included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).

Thu Jun 11 00:00:00 EDT 2020

Eradication of tumor growth by delivering novel photothermal selenium-coated tellurium nanoheterojunctions.

Science advances

Chen S,Xing C,Huang D,Zhou C,Ding B,Guo Z,Peng Z,Wang D,Zhu X,Liu S,Cai Z,Wu J,Zhao J,Wu Z,Zhang Y,Wei C,Yan Q,Wang H,Fan D,Liu L,Zhang H,Cao Y

14-5698 was used in Immunohistochemistry-immunofluorescence to develop and characterise a novel anti-cancer therapy using nanomaterial-based photothermal therapy (PTT).

Wed Apr 01 00:00:00 EDT 2020

Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke.

Cells

Santopolo G,Magnusson JP,Lindvall O,Kokaia Z,Frisén J

14-5698-82 was used in Immunocytochemistry to suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.

Mon Jul 20 00:00:00 EDT 2020

T_H17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.

Science immunology

Harbour SN,DiToro DF,Witte SJ,Zindl CL,Gao M,Schoeb TR,Jones GW,Jones SA,Hatton RD,Weaver CT

14-5698-82 was used in Immunocytochemistry to find that IL-6 signaling is required for both induction and maintenance of mouse TH17 cells; IL-6Rα-deficient TH17 cells rapidly lost their TH17 phenotype and did not cause disease in two models of colitis.

Fri Jul 17 00:00:00 EDT 2020

Yolk-sac-derived macrophages progressively expand in the mouse kidney with age.

eLife

Ide S,Yahara Y,Kobayashi Y,Strausser SA,Ide K,Watwe A,Xu-Vanpala S,Privratsky JR,Crowley SD,Shinohara ML,Alman BA,Souma T

14-5698 was used in Immunocytochemistry-immunoflourescence to find that yolk-sac-derived macrophages progressively expand in number with age and become a major contributor to the renal macrophage population in older mice.

Fri Apr 17 00:00:00 EDT 2020

DSCAM regulates delamination of neurons in the developing midbrain.

Science advances

Arimura N,Okada M,Taya S,Dewa KI,Tsuzuki A,Uetake H,Miyashita S,Hashizume K,Shimaoka K,Egusa S,Nishioka T,Yanagawa Y,Yamakawa K,Inoue YU,Inoue T,Kaibuchi K,Hoshino M

14-5698 was used in Immunohistochemistry to show that Down syndrome cell adhesion molecule (DSCAM) controls neuronal delamination by local suppression of the RapGEF2-Rap1-N-cadherin cascade at the apical endfeet in the dorsal midbrain.

Tue Sep 01 00:00:00 EDT 2020

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Apr 16 00:00:00 EDT 2019

Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.

Immunity

Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Apr 16 00:00:00 EDT 2019

Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.

Nature neuroscience

Shen M,Wang F,Li M,Sah N,Stockton ME,Tidei JJ,Gao Y,Korabelnikov T,Kannan S,Vevea JD,Chapman ER,Bhattacharyya A,van Praag H,Zhao X

14-5698-82 was used in Immunohistochemistry to show that FMRP-deficient immature neurons exhibit impaired dendritic maturation, altered expression of mitochondrial genes, fragmented mitochondria, impaired mitochondrial function, and increased oxidative stress.

Fri Mar 01 00:00:00 EST 2019

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

The Journal of experimental medicine

Fujino N,Brand OJ,Morgan DJ,Fujimori T,Grabiec AM,Jagger CP,Maciewicz RA,Yamada M,Itakura K,Sugiura H,Ichinose M,Hussell T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Sep 02 00:00:00 EDT 2019

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

The Journal of experimental medicine

Fujino N,Brand OJ,Morgan DJ,Fujimori T,Grabiec AM,Jagger CP,Maciewicz RA,Yamada M,Itakura K,Sugiura H,Ichinose M,Hussell T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Sep 02 00:00:00 EDT 2019

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

The Journal of experimental medicine

Fujino N,Brand OJ,Morgan DJ,Fujimori T,Grabiec AM,Jagger CP,Maciewicz RA,Yamada M,Itakura K,Sugiura H,Ichinose M,Hussell T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Sep 02 00:00:00 EDT 2019

An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma.

EMBO molecular medicine

Morabito M,Larcher M,Cavalli FM,Foray C,Forget A,Mirabal-Ortega L,Andrianteranagna M,Druillennec S,Garancher A,Masliah-Planchon J,Leboucher S,Debalkew A,Raso A,Delattre O,Puget S,Doz F,Taylor MD,Ayrault O,Bourdeaut F,Eychène A,Pouponnot C

14-5698-82 was used in Immunohistochemistry to demonstrate that an ActivinB autocrine stimulation is responsible for pathway activation in a subset of Group 3 MB characterized by high PMEPA1 levels.

Thu Aug 01 00:00:00 EDT 2019

High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b.

Developmental cell

Ooki T,Murata-Kamiya N,Takahashi-Kanemitsu A,Wu W,Hatakeyama M

14-5698 was used in Immunocytochemistry-immunoflourescence to show that treatment with high-molecular-weight hyaluronan stimulates tumor-suppressive Hippo signaling in breast epithelial cells.

Mon May 20 00:00:00 EDT 2019

Diabetes-Induced NF-κB Dysregulation in Skeletal Stem Cells Prevents Resolution of Inflammation.

Diabetes

Ko KI,Syverson AL,Kralik RM,Choi J,DerGarabedian BP,Chen C,Graves DT

14-5698-82 was used in Immunohistochemistry to demonstrate that type 1 diabetes induces NF-κB hyperactivation in skeletal stem cells to disrupt their ability to modulate M2 polarisation and resolve inflammation.

Fri Nov 01 00:00:00 EDT 2019

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.

Blood advances

Wan X,Liu L,Zhou P,Hui X,He Q,Yu F,Zhang W,Ding X,Yuan X,Zhang N,Zhao Y,Zhu R,Liu Y,Hao P,Auwerx J,Song X,Leng Q,Zhang Y

14-5698 was used in Flow cytometry/Cell sorting to identify nuclear receptor corepressor 1 having a key role in murine adult hematopoiesis and its contribution to MLL-AF9 induced leukemogenesis.

Tue Feb 26 00:00:00 EST 2019

JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression.

International journal of cancer

Mohrherr J,Haber M,Breitenecker K,Aigner P,Moritsch S,Voronin V,Eferl R,Moriggl R,Stoiber D,Győrffy B,Brcic L,László V,Döme B,Moldvay J,Dezső K,Bilban M,Popper H,Moll HP,Casanova E

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sun Dec 15 00:00:00 EST 2019

Evidence of a developmental origin for β-cell heterogeneity using a dual lineage-tracing technology.

Development (Cambridge, England)

Chen C,Shiota C,Agostinelli G,Ridley D,Jiang Y,Ma J,Prasadan K,Xiao X,Gittes GK

14-5698 was used in Immunohistochemistry to develop a dual lineage-tracing technology, using a combination of two recombinase systems, Dre/RoxP and Cre/LoxP, to independently trace green fluorescent Pdx1-lineage cells and red fluorescent Ptf1a-lineage cells in the developing and adult mouse pancreas.

Thu Jun 27 00:00:00 EDT 2019

Analysis of biological networks in the endothelium with biomimetic microsystem platform.

American journal of physiology. Lung cellular and molecular physiology

Kruse K,Klomp J,Sun M,Chen Z,Santana D,Huang F,Kanabar P,Maienschein-Cline M,Komarova YA

14-5698-82 was used in Immunocytochemistry to describe a novel method for studying the protein "interactome" in primary human cells and apply this method to investigate the effect of posttranslational protein modifications (PTMs) on the protein''s functions.

Sun Sep 01 00:00:00 EDT 2019

α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding.

Frontiers in chemistry

Lai AC,Chi PY,Thio CL,Han YC,Kao HN,Hsieh HW,Gervay-Hague J,Chang YJ

14-5698 was used in Flow cytometry/Cell sorting to study how inhibiting iNKT cell activation with α-Lactosylceramide can reduce development of murine airway hyperreactivity and liver injury by competing for CD1d binding.

Thu Oct 01 00:00:00 EDT 2020

p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects.

Human molecular genetics

Little JN,Dwyer ND

14-5698-82 was used in Immunohistochemistry to elucidate both NSC apoptosis and abscission mechanisms that could underlie human microcephaly or other brain malformations.

Fri Feb 01 00:00:00 EST 2019

Comprehensive and cell-type-based characterization of the dorsal midbrain during development.

Genes to cells : devoted to molecular & cellular mechanisms

Arimura N,Dewa KI,Okada M,Yanagawa Y,Taya SI,Hoshino M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Jan 01 00:00:00 EST 2019

Comprehensive and cell-type-based characterization of the dorsal midbrain during development.

Genes to cells : devoted to molecular & cellular mechanisms

Arimura N,Dewa KI,Okada M,Yanagawa Y,Taya SI,Hoshino M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Jan 01 00:00:00 EST 2019

SORLA regulates endosomal trafficking and oncogenic fitness of HER2.

Nature communications

Pietilä M,Sahgal P,Peuhu E,Jäntti NZ,Paatero I,Närvä E,Al-Akhrass H,Lilja J,Georgiadou M,Andersen OM,Padzik A,Sihto H,Joensuu H,Blomqvist M,Saarinen I,Boström PJ,Taimen P,Ivaska J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue May 28 00:00:00 EDT 2019

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Nature communications

Zhong L,Xu Y,Zhuo R,Wang T,Wang K,Huang R,Wang D,Gao Y,Zhu Y,Sheng X,Chen K,Wang N,Zhu L,Can D,Marten Y,Shinohara M,Liu CC,Du D,Sun H,Wen L,Xu H,Bu G,Chen XF

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Mar 25 00:00:00 EDT 2019

FCRL5⁺ Memory B Cells Exhibit Robust Recall Responses.

Cell reports

Kim CC,Baccarella AM,Bayat A,Pepper M,Fontana MF

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Apr 30 00:00:00 EDT 2019

Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.

Nature communications

Cheng HW,Onder L,Novkovic M,Soneson C,Lütge M,Pikor N,Scandella E,Robinson MD,Miyazaki JI,Tersteegen A,Sorg U,Pfeffer K,Rülicke T,Hehlgans T,Ludewig B

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Apr 15 00:00:00 EDT 2019

Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner.

Theranostics

Li J,Yang KY,Tam RCY,Chan VW,Lan HY,Hori S,Zhou B,Lui KO

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Aug 14 00:00:00 EDT 2020

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

The Journal of biological chemistry

Singh A,Mia MM,Cibi DM,Arya AK,Bhadada SK,Singh MK

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri May 24 00:00:00 EDT 2019

Deficiency in the secreted protein Semaphorin3d causes abnormal parathyroid development in mice.

The Journal of biological chemistry

Singh A,Mia MM,Cibi DM,Arya AK,Bhadada SK,Singh MK

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri May 24 00:00:00 EDT 2019

Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease.

Cellular and molecular gastroenterology and hepatology

Cansby E,Nuñez-Durán E,Magnusson E,Amrutkar M,Booten SL,Kulkarni NM,Svensson LT,Borén J,Marschall HU,Aghajan M,Mahlapuu M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Tue Jun 04 00:00:00 EDT 2019

Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Nature communications

Akram KM,Yates LL,Mongey R,Rothery S,Gaboriau DCA,Sanderson J,Hind M,Griffiths M,Dean CH

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Mar 12 00:00:00 EDT 2019

Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Nature communications

Akram KM,Yates LL,Mongey R,Rothery S,Gaboriau DCA,Sanderson J,Hind M,Griffiths M,Dean CH

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Mar 12 00:00:00 EDT 2019

Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture.

Scientific reports

Baldan J,Houbracken I,Rooman I,Bouwens L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Mon Mar 11 00:00:00 EDT 2019

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.

Cell reports

Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Apr 16 00:00:00 EDT 2019

Lymphoid Aggregates in the CNS of Progressive Multiple Sclerosis Patients Lack Regulatory T Cells.

Frontiers in immunology

Bell L,Lenhart A,Rosenwald A,Monoranu CM,Berberich-Siebelt F

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Oct 22 00:00:00 EDT 2020

Transcriptional Signature Derived from Murine Tumor-Associated Macrophages Correlates with Poor Outcome in Breast Cancer Patients.

Cell reports

Tuit S,Salvagno C,Kapellos TS,Hau CS,Seep L,Oestreich M,Klee K,de Visser KE,Ulas T,Schultze JL

14-5698 was used in Immunocytochemistry-immunoflourescence to show that a transgenic mouse tumor model can yield a TAM signature relevant for human breast cancer outcome prognosis and provide a generalizable strategy for determining and applying immune cell signatures provided the murine model reflects the human disease.

Tue Oct 29 00:00:00 EDT 2019

Lymphangiogenesis in kidney and lymph node mediates renal inflammation and fibrosis.

Science advances

Pei G,Yao Y,Yang Q,Wang M,Wang Y,Wu J,Wang P,Li Y,Zhu F,Yang J,Zhang Y,Yang W,Deng X,Zhao Z,Zhu H,Ge S,Han M,Zeng R,Xu G

14-5698 was used in Flow cytometry/Cell sorting to demonstrate that expanding lymphatic vessels (LVs) in kidneys and corresponding renal draining lymph nodes (RDLNs) play critical roles in promoting intrarenal inflammation and fibrosis following renal injury.

Sat Jun 01 00:00:00 EDT 2019

The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability.

Frontiers in immunology

Ronin E,Lubrano di Ricco M,Vallion R,Divoux J,Kwon HK,Grégoire S,Collares D,Rouers A,Baud V,Benoist C,Salomon BL

14-5698-82 was used in Flow Cytometry to show that RelA, a key member of the NF-κB complex, is critical for Treg biology as it promotes both the generation of their effector phenotype and the maintenance of their identity.

Thu Oct 29 00:00:00 EDT 2020

Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells.

Scientific reports

Goulart MR,Hlavaty SI,Chang YM,Polton G,Stell A,Perry J,Wu Y,Sharma E,Broxholme J,Lee AC,Szladovits B,Turmaine M,Gribben J,Xia D,Garden OA

14-5698-82 was used in Functional assay to validate the dog as a model for studying MDSCs in the context of cancer.

Tue Mar 05 00:00:00 EST 2019

Distinct response of adult neural stem cells to low versus high dose ionising radiation.

DNA repair

Barazzuol L,Hopkins SR,Ju L,Jeggo PA

14-5698-82 was used in Immunohistochemistry to examine the response of stem and progenitor cells in the subventricular zone to low IR doses (50-500 mGy).

Mon Apr 01 00:00:00 EDT 2019

Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.

Frontiers in immunology

Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A

14-5698 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.

Mon Sep 14 00:00:00 EDT 2020

Krt5⁺/Krt15⁺ foregut basal progenitors give rise to cyclooxygenase-2-dependent tumours in response to gastric acid stress.

Nature communications

Moon H,Zhu J,Donahue LR,Choi E,White AC

14-5698 was used in Immunohistochemistry-immunofluorescence to suggest that clinical management of microenvironmental stressor-mediated microscopic injury may be important in delaying tumor initiation from foregut basal progenitor cells expressing pre-existing tumorigenic mutation(s) and genetic alteration(s).

Mon May 20 00:00:00 EDT 2019

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.

Nature medicine

Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Cell

Mitroulis I,Ruppova K,Wang B,Chen LS,Grzybek M,Grinenko T,Eugster A,Troullinaki M,Palladini A,Kourtzelis I,Chatzigeorgiou A,Schlitzer A,Beyer M,Joosten LAB,Isermann B,Lesche M,Petzold A,Simons K,Henry I,Dahl A,Schultze JL,Wielockx B,Zamboni N,Mirtschink P,Coskun Ü,Hajishengallis G,Netea MG,Chavakis T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Jan 11 00:00:00 EST 2018

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling.

Cell

Schneider C,O'Leary CE,von Moltke J,Liang HE,Ang QY,Turnbaugh PJ,Radhakrishnan S,Pellizzon M,Ma A,Locksley RM

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Jul 12 00:00:00 EDT 2018

Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function.

Cell

Shah PT,Stratton JA,Stykel MG,Abbasi S,Sharma S,Mayr KA,Koblinger K,Whelan PJ,Biernaskie J

14-5698 was used in Immunohistochemistry to demonstrate stability of ependymal cell function and provide fundamental insights into the molecular signature of the V-SVZ niche.

Thu May 03 00:00:00 EDT 2018

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

Cancer cell

Arce Vargas F,Furness AJS,Litchfield K,Joshi K,Rosenthal R,Ghorani E,Solomon I,Lesko MH,Ruef N,Roddie C,Henry JY,Spain L,Ben Aissa A,Georgiou A,Wong YNS,Smith M,Strauss D,Hayes A,Nicol D,O'Brien T,Mårtensson L,Ljungars A,Teige I,Frendéus B,Pule M,Marafioti T,Gore M,Larkin J,Turajlic S,Swanton C,Peggs KS,Quezada SA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Apr 09 00:00:00 EDT 2018

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance.

Cell metabolism

Iwamoto H,Abe M,Yang Y,Cui D,Seki T,Nakamura M,Hosaka K,Lim S,Wu J,He X,Sun X,Lu Y,Zhou Q,Shi W,Torimura T,Nie G,Li Q,Cao Y

14-5698 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to describe AAD-triggered, lipid-dependent metabolic reprogramming as an alternative mechanism of AAD resistance.

Tue Jul 03 00:00:00 EDT 2018

The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.

Neuron

Baizabal JM,Mistry M,García MT,Gómez N,Olukoya O,Tran D,Johnson MB,Walsh CA,Harwell CC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Wed Jun 06 00:00:00 EDT 2018

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.

The Journal of experimental medicine

Zhang W,Li Q,Li D,Li J,Aki D,Liu YC

14-5698 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.

Mon Dec 03 00:00:00 EST 2018

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer.

Biomaterials

Miller-Kleinhenz J,Guo X,Qian W,Zhou H,Bozeman EN,Zhu L,Ji X,Wang YA,Styblo T,O'Regan R,Mao H,Yang L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Jan 01 00:00:00 EST 2018

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer.

Biomaterials

Miller-Kleinhenz J,Guo X,Qian W,Zhou H,Bozeman EN,Zhu L,Ji X,Wang YA,Styblo T,O'Regan R,Mao H,Yang L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Jan 01 00:00:00 EST 2018

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Developmental cell

Sznurkowska MK,Hannezo E,Azzarelli R,Rulands S,Nestorowa S,Hindley CJ,Nichols J,Göttgens B,Huch M,Philpott A,Simons BD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Aug 06 00:00:00 EDT 2018

Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development.

Developmental cell

Sznurkowska MK,Hannezo E,Azzarelli R,Rulands S,Nestorowa S,Hindley CJ,Nichols J,Göttgens B,Huch M,Philpott A,Simons BD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Aug 06 00:00:00 EDT 2018

PPAR-Induced Fatty Acid Oxidation in T Cells Increases the Number of Tumor-Reactive CD8⁺ T Cells and Facilitates Anti-PD-1 Therapy.

Cancer immunology research

Chowdhury PS,Chamoto K,Kumar A,Honjo T

14-5698 was used in Flow cytometry/Cell sorting to study the molecular mechanism of the synergistic effects of bezafibrate on the tumouricidal effects of PD-1 blockade.

Thu Nov 01 00:00:00 EDT 2018

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.

PLoS biology

Matesanz N,Nikolic I,Leiva M,Pulgarín-Alfaro M,Santamans AM,Bernardo E,Mora A,Herrera-Melle L,Rodríguez E,Beiroa D,Caballero A,Martín-García E,Acín-Pérez R,Hernández-Cosido L,Leiva-Vega L,Torres JL,Centeno F,Nebreda AR,Enríquez JA,Nogueiras R,Marcos M,Sabio G

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sun Jul 01 00:00:00 EDT 2018

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.

PLoS biology

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Sun Jul 01 00:00:00 EDT 2018

Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Tannenberg P,Chang YT,Muhl L,Laviña B,Gladh H,Genové G,Betsholtz C,Folestad E,Tran-Lundmark K

14-5698 was used in Immunohistochemistry-immunofluorescence to emphasize the importance of extracellular matrix-growth factor interactions and adds to previous knowledge of PDGF-B in PH pathobiology.

Sun Apr 01 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice.

International journal of molecular medicine

Nguyễn-Thanh T,Kim D,Lee S,Kim W,Park SK,Kang KP

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Jan 01 00:00:00 EST 2018

Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment.

Investigative ophthalmology & visual science

Kiang L,Ross BX,Yao J,Shanmugam S,Andrews CA,Hansen S,Besirli CG,Zacks DN,Abcouwer SF

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Jul 02 00:00:00 EDT 2018

MicroRNA-126 Deficiency Affects the Development of Thymus CD4+ Single-Positive Cells through Elevating IRS-1.

International archives of allergy and immunology

Hu L,Xu H,Lu J,Zhou Y,Chu F,Zheng W,Lei L,Zhao J,Wang H,Guo M,Chen C,Xu L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

C-Kit Cardiac Progenitor Cell Based Cell Sheet Improves Vascularization and Attenuates Cardiac Remodeling following Myocardial Infarction in Rats.

BioMed research international

Dergilev K,Tsokolaeva Z,Makarevich P,Beloglazova I,Zubkova E,Boldyreva M,Ratner E,Dyikanov D,Menshikov M,Ovchinnikov A,Ageev F,Parfyonova Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Jan 14 00:00:00 EST 2019

Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.

Nature communications

Lopes N,Charaix J,Cédile O,Sergé A,Irla M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Journal of translational medicine

Moll S,Yasui Y,Abed A,Murata T,Shimada H,Maeda A,Fukushima N,Kanamori M,Uhles S,Badi L,Cagarelli T,Formentini I,Drawnel F,Georges G,Bergauer T,Gasser R,Bonfil RD,Fridman R,Richter H,Funk J,Moeller MJ,Chatziantoniou C,Prunotto M

14-5698 was used in Immunohistochemistry to investigate the role and relevance of discoidin domain receptor 1 in human crescentic glomerulonephritis.

Fri Jun 01 00:00:00 EDT 2018

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime.

Journal of translational medicine

14-5698 was used in Immunohistochemistry to investigate the role and relevance of discoidin domain receptor 1 in human crescentic glomerulonephritis.

Fri Jun 01 00:00:00 EDT 2018

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.

Nature communications

Koren E,Yosefzon Y,Ankawa R,Soteriou D,Jacob A,Nevelsky A,Ben-Yosef R,Bar-Sela G,Fuchs Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Fri Nov 02 00:00:00 EDT 2018

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.

Nature communications

Koren E,Yosefzon Y,Ankawa R,Soteriou D,Jacob A,Nevelsky A,Ben-Yosef R,Bar-Sela G,Fuchs Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Fri Nov 02 00:00:00 EDT 2018

Pax6 Lengthens G1 Phase and Decreases Oscillating Cdk6 Levels in Murine Embryonic Cortical Progenitors.

Frontiers in cellular neuroscience

Mi D,Manuel M,Huang YT,Mason JO,Price DJ

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Mar 04 00:00:00 EST 2021

Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST.

Frontiers in cellular neuroscience

Stratton JA,Assinck P,Sinha S,Kumar R,Moulson A,Patrick N,Raharjo E,Chan JA,Midha R,Tetzlaff W,Biernaskie J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Thu Oct 01 00:00:00 EDT 2020

Pharmacological activation of epidermal growth factor receptor signaling inhibits colitis-associated cancer in mice.

Scientific reports

Dubé PE,Liu CY,Girish N,Washington MK,Polk DB

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Thu Jun 14 00:00:00 EDT 2018

The organic ester O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate dihydrochloride attenuates murine breast cancer growth and metastasis.

Oncotarget

Jurisevic M,Arsenijevic A,Pantic J,Gajovic N,Milovanovic J,Milovanovic M,Poljarevic J,Sabo T,Vojvodic D,Radosavljevic GD,Arsenijevic N

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

The transcription factor Klf5 is essential for intrahepatic biliary epithelial tissue remodeling after cholestatic liver injury.

The Journal of biological chemistry

Okada H,Yamada M,Kamimoto K,Kok CY,Kaneko K,Ema M,Miyajima A,Itoh T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Apr 27 00:00:00 EDT 2018

ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.

Frontiers in immunology

Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Sep 26 00:00:00 EDT 2019

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.

Nature communications

Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Fri Jun 22 00:00:00 EDT 2018

Genetic Deletion of P2Y₂ Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation.

Frontiers in physiology

Zhang Y,Riquier-Brison A,Liu T,Huang Y,Carlson NG,Peti-Peterdi J,Kishore BK

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner.

Cell stem cell

Petrik D,Myoga MH,Grade S,Gerkau NJ,Pusch M,Rose CR,Grothe B,Götz M

14-5698 was used in Immunohistochemistry to provide a role for a voltage- and ligandindependent ion channel in adult neurogenesis.

Fri Jun 01 00:00:00 EDT 2018

Identification of dynamic undifferentiated cell states within the male germline.

Nature communications

La HM,Mäkelä JA,Chan AL,Rossello FJ,Nefzger CM,Legrand JMD,De Seram M,Polo JM,Hobbs RM

14-5698 was used in Immunofluorescence in immunohistochemistry on frozen tissues to conclude that Aundiff exist in a series of dynamic cell states with distinct function and provide evidence that stability of such states is dictated by niche-derived cues.

Thu Jul 19 00:00:00 EDT 2018

Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration.

Cell stem cell

Yu Z,Jiang K,Xu Z,Huang H,Qian N,Lu Z,Chen D,Di R,Yuan T,Du Z,Xie W,Lu X,Li H,Chai R,Yang Y,Zhu B,Kunieda T,Wang F,Chen T

14-5698 was used in Immunohistochemistry to show that expression of Hoxc genes is sufficient to reprogram mesenchymal DP cells and alter the regenerative potential of epithelial stem cells.

Thu Oct 04 00:00:00 EDT 2018

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.

Nature

Mass E,Jacome-Galarza CE,Blank T,Lazarov T,Durham BH,Ozkaya N,Pastore A,Schwabenland M,Chung YR,Rosenblum MK,Prinz M,Abdel-Wahab O,Geissmann F

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Sep 21 00:00:00 EDT 2017

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Nature

Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Apr 06 00:00:00 EDT 2017

De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.

Cell

Ghoneim HE,Fan Y,Moustaki A,Abdelsamed HA,Dash P,Dogra P,Carter R,Awad W,Neale G,Thomas PG,Youngblood B

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Jun 29 00:00:00 EDT 2017

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function.

Cell research

Lee YH,Martin-Orozco N,Zheng P,Li J,Zhang P,Tan H,Park HJ,Jeong M,Chang SH,Kim BS,Xiong W,Zang W,Guo L,Liu Y,Dong ZJ,Overwijk WW,Hwu P,Yi Q,Kwak L,Yang Z,Mak TW,Li W,Radvanyi LG,Ni L,Liu D,Dong C

14-5698 was used in Flow cytometry/Cell sorting to indicate that the B7-H3 checkpoint may serve as a novel target for immunotherapy against cancer.

Tue Aug 01 00:00:00 EDT 2017

White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection.

Immunity

Han SJ,Glatman Zaretsky A,Andrade-Oliveira V,Collins N,Dzutsev A,Shaik J,Morais da Fonseca D,Harrison OJ,Tamoutounour S,Byrd AL,Smelkinson M,Bouladoux N,Bliska JB,Brenchley JM,Brodsky IE,Belkaid Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Dec 19 00:00:00 EST 2017

The transcription factor musculin promotes the unidirectional development of peripheral T_reg cells by suppressing the T_H2 transcriptional program.

Nature immunology

Wu C,Chen Z,Dardalhon V,Xiao S,Thalhamer T,Liao M,Madi A,Franca RF,Han T,Oukka M,Kuchroo V

14-5698 was used in Flow cytometry/Cell sorting to identify the TF Musculin (MSC) as critical for iTreg development by repression of TH2 transcriptional program, using Transforming growth factor-β (TGF-β) induced regulatory T cell (iTreg) system.

Wed Mar 01 00:00:00 EST 2017

Differential cytokine contributions of perivascular haematopoietic stem cell niches.

Nature cell biology

Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure.

Cell stem cell

Moon H,Donahue LR,Choi E,Scumpia PO,Lowry WE,Grenier JK,Zhu J,White AC

14-5698 was used in Immunohistochemistry-immunofluorescence to define the role of melanocyte stem cells as melanoma cells of origin, and identify the extrinsic factors required for the critical early steps of melanoma initiation.

Thu Nov 02 00:00:00 EDT 2017

Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.

The Journal of clinical investigation

Zang S,Li J,Yang H,Zeng H,Han W,Zhang J,Lee M,Moczygemba M,Isgandarova S,Yang Y,Zhou Y,Rao A,You MJ,Sun D,Huang Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

PD-1 regulates KLRG1⁺ group 2 innate lymphoid cells.

The Journal of experimental medicine

Taylor S,Huang Y,Mallett G,Stathopoulou C,Felizardo TC,Sun MA,Martin EL,Zhu N,Woodward EL,Elias MS,Scott J,Reynolds NJ,Paul WE,Fowler DH,Amarnath S

14-5698-82 was used in Flow Cytometry to report that PD-1 is required for maintaining the number, and hence function, of KLRG1+ Group 2 innate lymphoid cells.

Mon Jun 05 00:00:00 EDT 2017

Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.

EMBO molecular medicine

Lopes N,Vachon H,Marie J,Irla M

14-5698 was used in Flow cytometry/Cell sorting to indicate that RANKL may be clinically useful to improve T-cell function recovery after bone marrow transplantation by controlling multiple facets of thymic regeneration.

Thu Jun 01 00:00:00 EDT 2017

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.

The EMBO journal

Kawasaki T,Ito K,Miyata H,Akira S,Kawai T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Jun 14 00:00:00 EDT 2017

Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels.

Cancer research

Sobecki M,Mrouj K,Colinge J,Gerbe F,Jay P,Krasinska L,Dulic V,Fisher D

14-5698 was used in Immunofluorescence to explain that the variability of Ki-67 expression is due to cell-cycle regulation.

Mon May 15 00:00:00 EDT 2017

Maintenance of antiangiogenic and antitumor effects by orally active low-dose capecitabine for long-term cancer therapy.

Proceedings of the National Academy of Sciences of the United States of America

Zhang Y,Sun M,Huang G,Yin L,Lai Q,Yang Y,Xing X,Yu G,Sun Y,Wang X,Nie G,Liu Y,Cao Y

14-5698 was used in Immunohistochemistry-immunofluorescence to provide a rationalized concept of effective cancer therapy by long-term maintenance of AAD-triggered antiangiogenic effects with orally active, nontoxic, low-cost, clinically available chemotherapeutics.

Tue Jun 27 00:00:00 EDT 2017

Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection.

Proceedings of the National Academy of Sciences of the United States of America

Nikolaidis NM,Noel JG,Pitstick LB,Gardner JC,Uehara Y,Wu H,Saito A,Lewnard KE,Liu H,White MR,Hartshorn KL,McCormack FX

14-5698 was used in Flow cytometry/Cell sorting to investigate the role of mitogenic stimulation in susceptibility to pneumonia.

Tue Aug 08 00:00:00 EDT 2017

A coordinated DNA damage response promotes adult quiescent neural stem cell activation.

PLoS biology

Barazzuol L,Ju L,Jeggo PA

14-5698 was used in Immunohistochemistry-immunofluorescence to show distinct responses to ionising radiation between neural stem and progenitor cells.

Mon May 01 00:00:00 EDT 2017

1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8⁺ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.

Frontiers in immunology

Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors.

Stem cells (Dayton, Ohio)

Malinverno M,Corada M,Ferrarini L,Formicola L,Marazzi G,Sassoon D,Dejana E

14-5698 was used in Immunofluorescence to identify a subset of vessel associated endothelial cells with characteristics of progenitor cells.

Mon May 01 00:00:00 EDT 2017

The Major Histocompatibility Complex Class III Haplotype Ltab-Ncr3 Regulates Adjuvant-Induced but Not Antigen-Induced Autoimmunity.

The American journal of pathology

Yau ACY,Tuncel J,Holmdahl R

14-5698 was used in Flow cytometry/Cell sorting to find that Ltab-Ncr3 is specific in regulating adjuvant-induced arthritis but not antigen-induced autoimmunity.

Mon May 01 00:00:00 EDT 2017

Glucose-Dependent Insulinotropic Polypeptide Receptor Deficiency Leads to Impaired Bone Marrow Hematopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Mantelmacher FD,Fishman S,Cohen K,Pasmanik Chor M,Yamada Y,Zvibel I,Varol C

14-5698 was used in Flow cytometry/Cell sorting to show that significantly reduced representation and proliferation of hematopoietic stem and progenitor cells and myeloid progenitors in the bone marrow of Gipr-/- mice.

Sat Apr 15 00:00:00 EDT 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

14-5698 was used in Flow cytometry/Cell sorting to support the hypothesis that the Ox40/Ox40L pathway drives cellular and humoral autoimmune responses during lupus nephritis in NZB/W F1.

Tue Aug 15 00:00:00 EDT 2017

Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression.

Nature communications

Contrepois K,Coudereau C,Benayoun BA,Schuler N,Roux PF,Bischof O,Courbeyrette R,Carvalho C,Thuret JY,Ma Z,Derbois C,Nevers MC,Volland H,Redon CE,Bonner WM,Deleuze JF,Wiel C,Bernard D,Snyder MP,Rübe CE,Olaso R,Fenaille F,Mann C

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Wed May 10 00:00:00 EDT 2017

IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice.

Scientific reports

Shintani Y,Ito T,Fields L,Shiraishi M,Ichihara Y,Sato N,Podaru M,Kainuma S,Tanaka H,Suzuki K

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Mon Jul 31 00:00:00 EDT 2017

Neonatal pancreatic pericytes support β-cell proliferation.

Molecular metabolism

Epshtein A,Rachi E,Sakhneny L,Mizrachi S,Baer D,Landsman L

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Modeling African American prostate adenocarcinoma by inducing defined genetic alterations in organoids.

Oncotarget

Unno K,Roh M,Yoo YA,Al-Shraideh Y,Wang L,Nonn L,Abdulkadir SA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Aug 01 00:00:00 EDT 2017

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.

The Journal of biological chemistry

Kamizaki K,Doi R,Hayashi M,Saji T,Kanagawa M,Toda T,Fukada SI,Ho HH,Greenberg ME,Endo M,Minami Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Sep 22 00:00:00 EDT 2017

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle.

The Journal of biological chemistry

Kamizaki K,Doi R,Hayashi M,Saji T,Kanagawa M,Toda T,Fukada SI,Ho HH,Greenberg ME,Endo M,Minami Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Fri Sep 22 00:00:00 EDT 2017

Erythropoietin enhances Kupffer cell number and activity in the challenged liver.

Scientific reports

Gilboa D,Haim-Ohana Y,Deshet-Unger N,Ben-Califa N,Hiram-Bab S,Reuveni D,Zigmond E,Gassmann M,Gabet Y,Varol C,Neumann D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Sep 04 00:00:00 EDT 2017

A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning.

Nature communications

Fischer C,Seki T,Lim S,Nakamura M,Andersson P,Yang Y,Honek J,Wang Y,Gao Y,Chen F,Samani NJ,Zhang J,Miyake M,Oyadomari S,Yasue A,Li X,Zhang Y,Liu Y,Cao Y

14-5698 was used in Immunohistochemistry to provide mechanistic insight into an autocrine regulatory signalling loop that regulates beige adipocyte formation.

Tue Dec 12 00:00:00 EST 2017

Myelination is delayed during postnatal brain development in the mdx mouse model of Duchenne muscular dystrophy.

BMC neuroscience

Aranmolate A,Tse N,Colognato H

14-5698 was used in Immunohistochemistry to find that dystrophin is expressed in oligodendrocytes and influences developmental myelination important in finding potential contributors to brain dysfunction in DMD.

Mon Aug 14 00:00:00 EDT 2017

High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.

Scientific reports

Nakamizo S,Honda T,Adachi A,Nagatake T,Kunisawa J,Kitoh A,Otsuka A,Dainichi T,Nomura T,Ginhoux F,Ikuta K,Egawa G,Kabashima K

14-5698 was used in Flow cytometry/Cell sorting to indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.

Thu Oct 26 00:00:00 EDT 2017

LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells.

Oncotarget

Yang Y,Ren M,Song C,Li D,Soomro SH,Xiong Y,Zhang H,Fu H

14-5698 was used in Immunofluorescence to show that LINC00461 long non-coding RNA is highly expressed in glioma tissues and is important for glioma progression.

Fri Oct 13 00:00:00 EDT 2017

Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.

Nature communications

Reismann D,Stefanowski J,Günther R,Rakhymzhan A,Matthys R,Nützi R,Zehentmeier S,Schmidt-Bleek K,Petkau G,Chang HD,Naundorf S,Winter Y,Melchers F,Duda G,Hauser AE,Niesner RA

14-5698 was used in Immunocytochemistry-immunoflourescence to develop longitudinal intravital imaging of the bone marrow to analyse cellular dynamics within the deep marrow.

Mon Dec 18 00:00:00 EST 2017

Organoids model distinct Vitamin E effects at different stages of prostate cancer evolution.

Scientific reports

Njoroge RN,Unno K,Zhao JC,Naseem AF,Anker JF,McGee WA,Nonn L,Abdulkadir SA

14-5698 was used in Immunohistochemistry-immunofluorescence to demonstrate using organoid models that Vitamin E promotes tumorigenesis in the early stages of prostate cancer evolution.

Fri Nov 24 00:00:00 EST 2017

p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.

EBioMedicine

Kannappan R,Matsuda A,Ferreira-Martins J,Zhang E,Palano G,Czarna A,Cabral-Da-Silva MC,Bastos-Carvalho A,Sanada F,Ide N,Rota M,Blasco MA,Serrano M,Anversa P,Leri A

14-5698 was used in Immunocytochemistry-immunoflourescence to study the effects of a single extra-copy of p53 on cardiac progenitor cell function in the presence of oxidative stress.

Wed Feb 01 00:00:00 EST 2017

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice.

Nature medicine

Liang J,Zhang Y,Xie T,Liu N,Chen H,Geng Y,Kurkciyan A,Mena JM,Stripp BR,Jiang D,Noble PW

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunocytochemistry

Tue Nov 01 00:00:00 EDT 2016

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Nature

Fox RG,Lytle NK,Jaquish DV,Park FD,Ito T,Bajaj J,Koechlein CS,Zimdahl B,Yano M,Kopp J,Kritzik M,Sicklick J,Sander M,Grandgenett PM,Hollingsworth MA,Shibata S,Pizzo D,Valasek M,Sasik R,Scadeng M,Okano H,Kim Y,MacLeod AR,Lowy AM,Reya T

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Jun 16 00:00:00 EDT 2016

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Nature

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Jun 16 00:00:00 EDT 2016

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Oct 06 00:00:00 EDT 2016

Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells.

Science (New York, N.Y.)

Soucie EL,Weng Z,Geirsdóttir L,Molawi K,Maurizio J,Fenouil R,Mossadegh-Keller N,Gimenez G,VanHille L,Beniazza M,Favret J,Berruyer C,Perrin P,Hacohen N,Andrau JC,Ferrier P,Dubreuil P,Sidow A,Sieweke MH

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Fri Feb 12 00:00:00 EST 2016

RANKL/RANK control Brca1 mutation- .

Cell research

Sigl V,Owusu-Boaitey K,Joshi PA,Kavirayani A,Wirnsberger G,Novatchkova M,Kozieradzki I,Schramek D,Edokobi N,Hersl J,Sampson A,Odai-Afotey A,Lazaro C,Gonzalez-Suarez E,Pujana MA,Cimba F,Heyn H,Vidal E,Cruickshank J,Berman H,Sarao R,Ticevic M,Uribesalgo I,Tortola L,Rao S,Tan Y,Pfeiler G,Lee EY,Bago-Horvath Z,Kenner L,Popper H,Singer C,Khokha R,Jones LP,Penninger JM

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Jul 01 00:00:00 EDT 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene.

Circulation research

Lombardi R,Chen SN,Ruggiero A,Gurha P,Czernuszewicz GZ,Willerson JT,Marian AJ

14569882 was used in immunohistochemistry - paraffin section to discuss the cellular origins of fibroadipocytes in arrhythmogenic cardiomyopathy

Fri Jun 24 00:00:00 EDT 2016

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Circulation research

Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M

14-5698 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.

Fri Sep 16 00:00:00 EDT 2016

Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo.

Nucleic acids research

Yang Y,Poe JC,Yang L,Fedoriw A,Desai S,Magnuson T,Li Z,Fedoriw Y,Araki K,Gao Y,Tateishi S,Sarantopoulos S,Vaziri C

14-5698-82 was used in Flow Cytometry to investigate the physiological roles of Rad18 in DNA damage tolerance and carcinogenesis.

Thu May 19 00:00:00 EDT 2016

Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ.

Hepatology (Baltimore, Md.)

Yi J,Lu L,Yanger K,Wang W,Sohn BH,Stanger BZ,Zhang M,Martin JF,Ajani JA,Chen J,Lee JS,Song S,Johnson RL

14-5698 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to study the role of Hippo signalling pathway kinases, large tumour suppressor homologues 1 and 2, during mouse liver development.

Tue Nov 01 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.

Journal of immunology (Baltimore, Md. : 1950)

Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE

14-5698 was used in Flow cytometry/Cell sorting to suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.

Fri Jan 15 00:00:00 EST 2016

Schwann cell proliferation and differentiation that is induced by ferulic acid through MEK1/ERK1/2 signalling promotes peripheral nerve remyelination following crush injury in rats.

Experimental and therapeutic medicine

Zhu X,Li K,Guo X,Wang J,Xiang Y

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Whole Chromosome Instability induces senescence and promotes SASP.

Scientific reports

Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna C

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Wed Oct 12 00:00:00 EDT 2016

Whole Chromosome Instability induces senescence and promotes SASP.

Scientific reports

Andriani GA,Almeida VP,Faggioli F,Mauro M,Tsai WL,Santambrogio L,Maslov A,Gadina M,Campisi J,Vijg J,Montagna C

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Wed Oct 12 00:00:00 EDT 2016

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

JCI insight

Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Jul 21 00:00:00 EDT 2016

Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney.

JCI insight

Sato Y,Mii A,Hamazaki Y,Fujita H,Nakata H,Masuda K,Nishiyama S,Shibuya S,Haga H,Ogawa O,Shimizu A,Narumiya S,Kaisho T,Arita M,Yanagisawa M,Miyasaka M,Sharma K,Minato N,Kawamoto H,Yanagita M

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Jul 21 00:00:00 EDT 2016

Detection of Cell Proliferation Markers by Immunofluorescence Staining and Microscopy Imaging in Paraffin-Embedded Tissue Sections.

Current protocols in molecular biology

Eminaga S,Teekakirikul P,Seidman CE,Seidman JG

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Fri Jul 01 00:00:00 EDT 2016

Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma.

Oncoimmunology

Büchel G,Schulte JH,Harrison L,Batzke K,Schüller U,Hansen W,Schramm A

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.

eLife

Ramo K,Sugamura K,Craige S,Keaney JF,Davis RJ

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Aug 09 00:00:00 EDT 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

The cell proliferation antigen Ki-67 organises heterochromatin.

eLife

Sobecki M,Mrouj K,Camasses A,Parisis N,Nicolas E,Llères D,Gerbe F,Prieto S,Krasinska L,David A,Eguren M,Birling MC,Urbach S,Hem S,Déjardin J,Malumbres M,Jay P,Dulic V,Lafontaine DLj,Feil R,Fisher D

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Mon Mar 07 00:00:00 EST 2016

Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.

PloS one

Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ

14-5698 was used in Flow cytometry/Cell sorting to exhibit a preclinical strategy for the identification and development of highly effective antitumour combination immunotherapies.

Fri Aug 25 00:00:00 EDT 2017

Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization.

JCI insight

Pilat N,Mahr B,Unger L,Hock K,Schwarz C,Farkas AM,Baranyi U,Wrba F,Wekerle T

14-5698 was used in Flow cytometry/Cell sorting to suggest that deletion of donor-reactive T cells for specificities expressed on hematopoietic cells preclude the expansion of donor-specific Tregs.

Thu May 19 00:00:00 EDT 2016

Accelerating skin wound healing by M-CSF through generating SSEA-1 and -3 stem cells in the injured sites.

Scientific reports

Li Y,Jalili RB,Ghahary A

14-5698 was used in Immunofluorescence to demonstrate that M-CSF induces hematopoietic cell dedifferentiation into SSEA-1 and -3 stem cells, accelerating skin wound healing.

Fri Jul 01 00:00:00 EDT 2016

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.

Nature medicine

Lovisa S,LeBleu VS,Tampe B,Sugimoto H,Vadnagara K,Carstens JL,Wu CC,Hagos Y,Burckhardt BC,Pentcheva-Hoang T,Nischal H,Allison JP,Zeisberg M,Kalluri R

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Tue Sep 01 00:00:00 EDT 2015

Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

Circulation research

Ye YX,Calcagno C,Binderup T,Courties G,Keliher EJ,Wojtkiewicz GR,Iwamoto Y,Tang J,Pérez-Medina C,Mani V,Ishino S,Johnbeck CB,Knigge U,Fayad ZA,Libby P,Weissleder R,Tawakol A,Dubey S,Belanger AP,Di Carli MF,Swirski FK,Kjaer A,Mulder WJ,Nahrendorf M

14-5698 was used in Immunohistochemistry to performF-FLT positron emission tomography-computed tomography was performed in mice, rabbits, and humans with atherosclerosis.

Fri Oct 23 00:00:00 EDT 2015

Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.

Journal of immunology (Baltimore, Md. : 1950)

Evonuk KS,Baker BJ,Doyle RE,Moseley CE,Sestero CM,Johnston BP,De Sarno P,Tang A,Gembitsky I,Hewett SJ,Weaver CT,Raman C,DeSilva TM

14-5698 was used in Flow cytometry/Cell sorting to investigate the link between inflammation and glutamate dysregulation in EAE, showing that inhibition of system Xc(-) transporter attenuates autoimmune inflammatory demyelination.

Wed Jul 15 00:00:00 EDT 2015

Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells.

Journal of cell science

Barazzuol L,Rickett N,Ju L,Jeggo PA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2015

Role of testicular luminal factors on Basal cell elongation and proliferation in the mouse epididymis.

Biology of reproduction

Kim B,Roy J,Shum WW,Da Silva N,Breton S

14-5698 was used in Immunohistochemistry to conclude that luminal testicular factors play an important role in basal cells extending their body projections towards the lumen.

Thu Jan 01 00:00:00 EST 2015

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development.

Nature communications

Giera S,Deng Y,Luo R,Ackerman SD,Mogha A,Monk KR,Ying Y,Jeong SJ,Makinodan M,Bialas AR,Chang BS,Stevens B,Corfas G,Piao X

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Wed Jan 21 00:00:00 EST 2015

Mammary Stem Cells and Tumor-Initiating Cells Are More Resistant to Apoptosis and Exhibit Increased DNA Repair Activity in Response to DNA Damage.

Stem cell reports

Chang CH,Zhang M,Rajapakshe K,Coarfa C,Edwards D,Huang S,Rosen JM

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.

Nature communications

Yan S,Xu Z,Lou F,Zhang L,Ke F,Bai J,Liu Z,Liu J,Wang H,Zhu H,Sun Y,Cai W,Gao Y,Su B,Li Q,Yang X,Yu J,Lai Y,Yu XZ,Zheng Y,Shen N,Chin YE,Wang H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Jul 03 00:00:00 EDT 2015

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis.

Nature communications

Yan S,Xu Z,Lou F,Zhang L,Ke F,Bai J,Liu Z,Liu J,Wang H,Zhu H,Sun Y,Cai W,Gao Y,Su B,Li Q,Yang X,Yu J,Lai Y,Yu XZ,Zheng Y,Shen N,Chin YE,Wang H

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunohistochemistry

Fri Jul 03 00:00:00 EDT 2015

DNAM-1 expression marks an alternative program of NK cell maturation.

Cell reports

Martinet L,Ferrari De Andrade L,Guillerey C,Lee JS,Liu J,Souza-Fonseca-Guimaraes F,Hutchinson DS,Kolesnik TB,Nicholson SE,Huntington ND,Smyth MJ

14-5698 was used in Flow cytometry/Cell sorting to reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.

Tue Apr 07 00:00:00 EDT 2015

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.

Nature communications

Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH

14-5698 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.

Fri Apr 10 00:00:00 EDT 2015

Alveolar progenitor and stem cells in lung development, renewal and cancer.

Nature

Desai TJ,Brownfield DG,Krasnow MA

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Mar 13 00:00:00 EDT 2014

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Nature communications

Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Oct 28 00:00:00 EDT 2014

Cytoskeletal regulation by AUTS2 in neuronal migration and neuritogenesis.

Cell reports

Hori K,Nagai T,Shan W,Sakamoto A,Taya S,Hashimoto R,Hayashi T,Abe M,Yamazaki M,Nakao K,Nishioka T,Sakimura K,Yamada K,Kaibuchi K,Hoshino M

14-5698 was used in Immunofluorescence to demonstrate a role for cytoplasmic AUTS2 in the regulation of Rho family GTPases contributing to neural development.

Wed Dec 24 00:00:00 EST 2014

Potential role of IL-17-producing iNKT cells in type 1 diabetes.

PloS one

Li S,Joseph C,Becourt C,Klibi J,Luce S,Dubois-Laforgue D,Larger E,Boitard C,Benlagha K

14-5698 was used in Flow cytometry/Cell sorting to investigate the status and potential role of iNKT17 in type 1 diabetes.

Thu Jan 22 00:00:00 EST 2015

Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammation.

Nature communications

Cai Y,Xue F,Fleming C,Yang J,Ding C,Ma Y,Liu M,Zhang HG,Zheng J,Xiong N,Yan J

14-5698 was used in Flow cytometry/Cell sorting to reveal a differential developmental requirement and peripheral regulation for dermal Vγ6 and Vγ4 γδT cells.

Mon Jun 09 00:00:00 EDT 2014

Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by Keratin 14 promoter.

Toxicological sciences : an official journal of the Society of Toxicology

Murakami S,Yamamoto M,Motohashi H

14-5698 was used in Flow cytometry/Cell sorting to analyse the bone marrow and spleen of transgenic mice to understand how aryl-hydrocarbon receptor-provoked allergy affects haematopoiesis.

Sat Mar 01 00:00:00 EST 2014

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

eLife

Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG

14-5698 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.

Mon Oct 27 00:00:00 EDT 2014

Dedifferentiation of committed epithelial cells into stem cells in vivo.

Nature

Tata PR,Mou H,Pardo-Saganta A,Zhao R,Prabhu M,Law BM,Vinarsky V,Cho JL,Breton S,Sahay A,Medoff BD,Rajagopal J

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Nov 14 00:00:00 EST 2013

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8⁺ T cell responses to influenza A virus.

Nature immunology

Pang IK,Ichinohe T,Iwasaki A

Fri Mar 01 00:00:00 EST 2013

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection.

The Journal of experimental medicine

Vom Berg J,Vrohlings M,Haller S,Haimovici A,Kulig P,Sledzinska A,Weller M,Becher B

14-5698 was used in Flow cytometry/Cell sorting to study intratumoral elicitors of T-cell mediated glioma rejection.

Mon Dec 16 00:00:00 EST 2013

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.

Cancer immunology research

Selby MJ,Engelhardt JJ,Quigley M,Henning KA,Chen T,Srinivasan M,Korman AJ

14-5698 was used in Flow cytometry/Cell sorting to analyse the mechanism of action of anti-CTLA-4 antibodies against tumours in greater detail.

Mon Jul 01 00:00:00 EDT 2013

Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens.

Journal of immunology (Baltimore, Md. : 1950)

Yammani RD,Haas KM

Mon Apr 01 00:00:00 EDT 2013

Small intestine inflammation in Roquin-mutant and Roquin-deficient mice.

PloS one

Schaefer JS,Montufar-Solis D,Nakra N,Vigneswaran N,Klein JR

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Flow Cytometry

Tue Sep 03 00:00:00 EDT 2013

Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice.

PloS one

Liu J,Copland DA,Horie S,Wu WK,Chen M,Xu Y,Paul Morgan B,Mack M,Xu H,Nicholson LB,Dick AD

Published figure using Ki-67 monoclonal antibody (Product # 14-5698-82) in Immunofluorescence

Thu Jan 15 00:00:00 EST 2015

Regulatory T cells in γ irradiation-induced immune suppression.

PloS one

McFarland HI,Puig M,Grajkowska LT,Tsuji K,Lee JP,Mason KP,Verthelyi D,Rosenberg AS

14-5698 was used in Flow cytometry/Cell sorting to show that in mice primed to an MHC class I alloantigen, the accelerated graft rejection T memory response is specifically lost several weeks following TBI.

Wed Dec 12 00:00:00 EST 2012

Bioinformatics

Protein Aliases: Antigen identified by monoclonal antibody Ki-67; Antigen identified by monoclonal antibody Ki-67 homolog; Antigen KI-67; Antigen KI-67 homolog; Proliferation marker protein Ki-67; proliferation-related Ki-67 antigen; protein phosphatase 1, regulatory subunit 105; RP11-380J17.2; unnamed protein product

Gene Aliases: D630048A14Rik; Ki-67; Ki67; KIA; MIB-; MIB-1; MKI67; PPP1R105

UniProt ID: (Human) P46013, (Mouse) E9PVX6

Entrez Gene ID: (Dog) 100686578, (Human) 4288, (Cynomolgus monkey) 102135895, (Rat) 291234, (Mouse) 17345

Function(s)

DNA metabolic process meiotic nuclear division cell proliferation response to organic cyclic compound hyaluronan metabolic process organ regeneration cellular response to heat hepatocyte proliferation cholangiocyte proliferation

Process(es)

protein binding ATP binding protein C-terminus binding poly(A) RNA binding molecular_function

Ki-67 Monoclonal Antibody (SolA15), eBioscience™

Ki-67 Antibody (14-5698-82) in IHC (P)

Product Details

14-5698-82

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Functional Assay (FN)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

RRID

Product Specific Information

Target Information

Bioinformatics

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